Centre for Gene Therapeutics,
Department of Pathology and Molecular Medicine
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Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors.
Journal of virology Oct, 1999 | Pubmed ID: 10482551
Role of dendritic cell-derived cytokines in immune regulation.
Current pharmaceutical design Jul, 2001 | Pubmed ID: 11472250
Dendritic cell-derived IL-12 is not required for the generation of cytotoxic, IFN-gamma-secreting, CD8(+) CTL in vivo.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2001 | Pubmed ID: 11673511
Adenoviral-mediated gene transfer of lymphotactin to the lungs of mice and rats results in infiltration and direct accumulation of CD4+, CD8+, and NK cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research May, 2002 | Pubmed ID: 12060496
High-dimensional architectures from the self-assembly of lanthanide ions with benzenedicarboxylates and 1,10-phenanthroline.
Inorganic chemistry Aug, 2003 | Pubmed ID: 12895124
A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer.
Cancer gene therapy Oct, 2003 | Pubmed ID: 14502228
TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.
The Journal of clinical investigation Feb, 2004 | Pubmed ID: 14755337
Vaccination-induced autoimmune vitiligo is a consequence of secondary trauma to the skin.
Cancer research Feb, 2004 | Pubmed ID: 14973051
CTL-dependent and -independent antitumor immunity is determined by the tumor not the vaccine.
Journal of immunology (Baltimore, Md. : 1950) May, 2004 | Pubmed ID: 15100257
T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice.
Journal of applied physiology (Bethesda, Md. : 1985) Dec, 2004 | Pubmed ID: 15286049
Recent advances in the development of adenovirus- and poxvirus-vectored tuberculosis vaccines.
Current gene therapy Oct, 2005 | Pubmed ID: 16250889
Recombinant adenovirus vaccines can successfully elicit CD8+ T cell immunity under conditions of extreme leukopenia.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2006 | Pubmed ID: 16297666
Development of cell-based tuberculosis vaccines: genetically modified dendritic cell vaccine is a much more potent activator of CD4 and CD8 T cells than peptide- or protein-loaded counterparts.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2006 | Pubmed ID: 16343993
The CD8+ T cell population elicited by recombinant adenovirus displays a novel partially exhausted phenotype associated with prolonged antigen presentation that nonetheless provides long-term immunity.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2006 | Pubmed ID: 16365411
Cigarette smoke impairs NK cell-dependent tumor immune surveillance.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2007 | Pubmed ID: 17202355
On the role of CD4+ T cells in the CD8+ T-cell response elicited by recombinant adenovirus vaccines.
Molecular therapy : the journal of the American Society of Gene Therapy May, 2007 | Pubmed ID: 17375073
Elevated frequencies of self-reactive CD8+ T cells following immunization with a xenoantigen are due to the presence of a heteroclitic CD4+ T-cell helper epitope.
Cancer research Jul, 2007 | Pubmed ID: 17616707
Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2007 | Pubmed ID: 17911587
Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2008 | Pubmed ID: 18059374
Enhanced protein expression by internal ribosomal entry site-driven mRNA translation as a novel approach for in vitro loading of dendritic cells with antigens.
Human immunology Jan, 2008 | Pubmed ID: 18295673
The magnitude of the CD8+ T cell response produced by recombinant virus vectors is a function of both the antigen and the vector.
Cellular immunology Nov-Dec, 2007 | Pubmed ID: 18313652
Mucosally delivered dendritic cells activate T cells independently of IL-12 and endogenous APCs.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2008 | Pubmed ID: 18684925
CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis.
European journal of immunology May, 2009 | Pubmed ID: 19338001
Neoadjuvant vaccination provides superior protection against tumor relapse following surgery compared with adjuvant vaccination.
Cancer research May, 2009 | Pubmed ID: 19383917
Recombinant vesicular stomatitis virus transduction of dendritic cells enhances their ability to prime innate and adaptive antitumor immunity.
Molecular therapy : the journal of the American Society of Gene Therapy Aug, 2009 | Pubmed ID: 19401673
Vesicular stomatitis virus as a novel cancer vaccine vector to prime antitumor immunity amenable to rapid boosting with adenovirus.
Molecular therapy : the journal of the American Society of Gene Therapy Oct, 2009 | Pubmed ID: 19603003
Autophagy facilitates major histocompatibility complex class I expression induced by IFN-γ in B16 melanoma cells.
Cancer immunology, immunotherapy : CII Feb, 2010 | Pubmed ID: 19680649
Persistence of transgene expression influences CD8+ T-cell expansion and maintenance following immunization with recombinant adenovirus.
Journal of virology Dec, 2009 | Pubmed ID: 19759135
Processing of tumor antigen differentially impacts the development of helper and effector CD4+ T-cell responses.
Molecular therapy : the journal of the American Society of Gene Therapy Jun, 2010 | Pubmed ID: 20179673
Immunotherapy can reject intracranial tumor cells without damaging the brain despite sharing the target antigen.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2010 | Pubmed ID: 20237288
Potentiating cancer immunotherapy using an oncolytic virus.
Molecular therapy : the journal of the American Society of Gene Therapy Aug, 2010 | Pubmed ID: 20551919
CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells.
Blood Jan, 2011 | Pubmed ID: 21088134
Adaptive antiviral immunity is a determinant of the therapeutic success of oncolytic virotherapy.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2011 | Pubmed ID: 21119618
Tolerogenic dendritic cells and their potential applications.
Immunology Mar, 2011 | Pubmed ID: 21208205
IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells.
Cancer research Apr, 2011 | Pubmed ID: 21307131
Engineering dendritic cells to enhance cancer immunotherapy.
Molecular therapy : the journal of the American Society of Gene Therapy May, 2011 | Pubmed ID: 21468005
Combined mTOR Inhibition and OX40 Agonism Enhances CD8(+) T Cell Memory and Protective Immunity Produced by Recombinant Adenovirus Vaccines.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2011 | Pubmed ID: 22186790
ORFV: A Novel Oncolytic and Immune Stimulating Parapoxvirus Therapeutic.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2012 | Pubmed ID: 22273579
Combined vaccination and immunostimulatory antibodies provides durable cure of murine melanoma and induces transcriptional changes associated with positive outcome in human melanoma patients.
Oncoimmunology Jul, 2012 | Pubmed ID: 22754760
HDAC inhibition suppresses primary immune responses, enhances secondary immune responses, and abrogates autoimmunity during tumor immunotherapy.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2013 | Pubmed ID: 23295947
Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8(+) T-cell recall responses.
Blood Mar, 2013 | Pubmed ID: 23325836
Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) May, 2013 | Pubmed ID: 23554310
Oncolytic vesicular stomatitis virus quantitatively and qualitatively improves primary CD8 T-cell responses to anticancer vaccines.
Oncoimmunology Aug, 2013 | Pubmed ID: 24083086
Immunotherapy-induced CD8+ T cells instigate immune suppression in the tumor.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2014 | Pubmed ID: 24196579
Maraba virus as a potent oncolytic vaccine vector.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2014 | Pubmed ID: 24322333
Chemotherapy and Oncolytic Virotherapy: Advanced Tactics in the War against Cancer.
Frontiers in oncology , 2014 | Pubmed ID: 24967214
Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling.
Cancer immunology research Feb, 2015 | Pubmed ID: 25477253
Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity.
Innate immunity Aug, 2015 | Pubmed ID: 25749844
T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice.
Molecular therapy : the journal of the American Society of Gene Therapy Oct, 2015 | Pubmed ID: 26122933
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Nature immunology May, 2016 | Pubmed ID: 27043414
High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells.
PloS one , 2016 | Pubmed ID: 27064901
Estradiol Enhances CD4+ T-Cell Anti-Viral Immunity by Priming Vaginal DCs to Induce Th17 Responses via an IL-1-Dependent Pathway.
PLoS pathogens 05, 2016 | Pubmed ID: 27148737
Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2016 | Pubmed ID: 27183620
Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy.
Oncolytic virotherapy , 2015 | Pubmed ID: 27512679
Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFNγ-producing NK Cells.
Molecular therapy : the journal of the American Society of Gene Therapy Feb, 2008 | Pubmed ID: 28178541
Capitalizing on Cancer Specific Replication: Oncolytic Viruses as a Versatile Platform for the Enhancement of Cancer Immunotherapy Strategies.
Biomedicines Aug, 2016 | Pubmed ID: 28536388
Customized Viral Immunotherapy for HPV-Associated Cancer.
Cancer immunology research Oct, 2017 | Pubmed ID: 28912369
A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8 T cells.
Nature cell biology 01, 2018 | Pubmed ID: 29230018
Preclinical development of peptide vaccination combined with oncolytic MG1-E6E7 for HPV-associated cancer.
Vaccine 04, 2018 | Pubmed ID: 29544689
Transforming the prostatic tumor microenvironment with oncolytic virotherapy.
Oncoimmunology , 2018 | Pubmed ID: 29900060
HDACi Delivery Reprograms Tumor-Infiltrating Myeloid Cells to Eliminate Antigen-Loss Variants.
Cell reports 07, 2018 | Pubmed ID: 30021162
Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity.
The Journal of clinical investigation 02, 2019 | Pubmed ID: 30422820
Development and applications of oncolytic Maraba virus vaccines.
Oncolytic virotherapy , 2018 | Pubmed ID: 30538968
Preclinical evaluation of a MAGE-A3 vaccination utilizing the oncolytic Maraba virus currently in first-in-human trials.
Oncoimmunology , 2019 | Pubmed ID: 30546947
Endogenous T cells prevent tumor immune escape following adoptive T cell therapy.
The Journal of clinical investigation 12, 2019 | Pubmed ID: 31682239
Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 T-cell memory development.
Nature cell biology 01, 2020 | Pubmed ID: 31871320
A rational relationship: Oncolytic virus vaccines as functional partners for adoptive T cell therapy.
Cytokine & growth factor reviews Dec, 2020 | Pubmed ID: 32665126
Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning.
Journal for immunotherapy of cancer 08, 2020 | Pubmed ID: 32792361
De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors.
Communications biology Nov, 2020 | Pubmed ID: 33149194
A Transit Time-Resolved Microflow Cytometry-Based Agglutination Immunoassay for On-Site C-Reactive Protein Detection.
Micromachines Jan, 2021 | Pubmed ID: 33499089
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