Neurobiology Laboratory
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Verapamil protects dopaminergic neuron damage through a novel anti-inflammatory mechanism by inhibition of microglial activation.
Neuropharmacology Feb-Mar, 2011 | Pubmed ID: 20950631
Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity.
Journal of neuroinflammation Jan, 2011 | Pubmed ID: 21232086
β2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2011 | Pubmed ID: 21335487
Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GDNF in astroglia [corrected].
Neuropharmacology Sep, 2011 | Pubmed ID: 21586298
Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox.
Free radical biology & medicine Jan, 2012 | Pubmed ID: 22094225
Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Jun, 2012 | Pubmed ID: 22205542
Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase.
Journal of neuroinflammation Feb, 2012 | Pubmed ID: 22340895
Inflammation in patients with schizophrenia: the therapeutic benefits of risperidone plus add-on dextromethorphan.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Sep, 2012 | Pubmed ID: 22730040
Preparation of rodent primary cultures for neuron-glia, mixed glia, enriched microglia, and reconstituted cultures with microglia.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23813383
The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia.
Progress in neuro-psychopharmacology & biological psychiatry Jun, 2014 | Pubmed ID: 24468644
Inducible nitric oxide synthase is key to peroxynitrite-mediated, LPS-induced protein radical formation in murine microglial BV2 cells.
Free radical biology & medicine Aug, 2014 | Pubmed ID: 24746617
Subpicomolar diphenyleneiodonium inhibits microglial NADPH oxidase with high specificity and shows great potential as a therapeutic agent for neurodegenerative diseases.
Glia Dec, 2014 | Pubmed ID: 25043383
Microglial regulation of immunological and neuroprotective functions of astroglia.
Glia Jan, 2015 | Pubmed ID: 25130274
Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2014 | Pubmed ID: 25209287
PGE2 Inhibits IL-10 Production via EP2-Mediated β-Arrestin Signaling in Neuroinflammatory Condition.
Molecular neurobiology Aug, 2015 | Pubmed ID: 25218510
The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients.
Scientific reports Feb, 2015 | Pubmed ID: 25640280
Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models.
Brain : a journal of neurology May, 2015 | Pubmed ID: 25716193
A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis.
Glia Jun, 2015 | Pubmed ID: 25740080
Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration.
Current opinion in pharmacology Feb, 2016 | Pubmed ID: 26498406
Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals.
Brain, behavior, and immunity 07, 2016 | Pubmed ID: 27132056
Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase.
Journal of neuroinflammation 05, 2016 | Pubmed ID: 27184631
En masse lentiviral gene delivery to mouse fertilized eggs via laser perforation of zona pellucida.
Transgenic research 02, 2018 | Pubmed ID: 29442214
Physiological Concentration of Prostaglandin E Exerts Anti-inflammatory Effects by Inhibiting Microglial Production of Superoxide Through a Novel Pathway.
Molecular neurobiology Oct, 2018 | Pubmed ID: 29492849
Sulfotransferase 4A1 Increases Its Expression in Mouse Neurons as They Mature.
Drug metabolism and disposition: the biological fate of chemicals 06, 2018 | Pubmed ID: 29626075
Negin P. Martin*,1,
Page Myers*,2,
Eugenia Goulding1,
Shih-Heng Chen1,
Mitzie Walker1,
Thomas M. Porter1,
Lucas Van Gorder1,
Amanda Mathew1,
Artiom Gruzdev3,
Erica Scappini4,
Charles Romeo1
1Neurobiology Laboratory, National Institute of Environmental Health Sciences,
2Comparative Medicine Branch, National Institute of Environmental Health Sciences,
3Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences,
4Signal Transduction Laboratory, National Institute of Environmental Health Sciences
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