Institute of Developmental Genetics,
Helmholtz Zentrum,
Institute of Developmental Genetics, Helmholtz Zentrum
Wolfgang Wurst has not added Biography.
If you are Wolfgang Wurst and would like to personalize this page please email our Author Liaison for assistance.
Novel allele of crybb2 in the mouse and its expression in the brain.
Investigative ophthalmology & visual science Apr, 2008 | Pubmed ID: 18385073
Activation of ERK/MAPK in the lateral amygdala of the mouse is required for acquisition of a fear-potentiated startle response.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Jan, 2009 | Pubmed ID: 18432190
Novel caspase-suicide proteins for tamoxifen-inducible apoptosis.
Genesis (New York, N.Y. : 2000) Oct, 2008 | Pubmed ID: 18802959
Pleiotropic effects in Eya3 knockout mice.
BMC developmental biology Dec, 2008 | Pubmed ID: 19102749
Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import.
Biochimica et biophysica acta May, 2009 | Pubmed ID: 19111522
Mitochondrial glutathione peroxidase 4 disruption causes male infertility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Sep, 2009 | Pubmed ID: 19417079
Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.
PloS one Jun, 2009 | Pubmed ID: 19562077
Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine.
Genome biology , 2009 | Pubmed ID: 19646228
Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.
Mammalian genome : official journal of the International Mammalian Genome Society Feb, 2010 | Pubmed ID: 20033184
The specific role of histone deacetylase 2 in adult neurogenesis.
Neuron glia biology May, 2010 | Pubmed ID: 20388229
Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice.
Sleep Apr, 2010 | Pubmed ID: 20394311
Phenotypic annotation of the mouse X chromosome.
Genome research Aug, 2010 | Pubmed ID: 20548051
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.
The EMBO journal Jul, 2010 | Pubmed ID: 20551902
Gene knockdown in the mouse through RNAi.
Methods in enzymology , 2010 | Pubmed ID: 20699152
Mouse phenotyping.
Methods (San Diego, Calif.) Feb, 2011 | Pubmed ID: 20708688
Constitutive and conditional RNAi transgenesis in mice.
Methods (San Diego, Calif.) Apr, 2011 | Pubmed ID: 21184828
A powerful transgenic tool for fate mapping and functional analysis of newly generated neurons.
BMC neuroscience Dec, 2010 | Pubmed ID: 21194452
Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling.
Neurobiology of disease Jun, 2011 | Pubmed ID: 21296667
Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice.
The Journal of biological chemistry May, 2011 | Pubmed ID: 21467037
Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2011 | Pubmed ID: 21940453
Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Mar, 2012 | Pubmed ID: 22113086
Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.
Experimental neurology May, 2012 | Pubmed ID: 22265660
Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
PLoS genetics , 2012 | Pubmed ID: 22438821
MAPK signaling determines anxiety in the juvenile mouse brain but depression-like behavior in adults.
PloS one , 2012 | Pubmed ID: 22529971
Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms.
Human molecular genetics Aug, 2012 | Pubmed ID: 22589248
Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests.
BMC neuroscience Jun, 2012 | Pubmed ID: 22682077
Innovations in phenotyping of mouse models in the German Mouse Clinic.
Mammalian genome : official journal of the International Mammalian Genome Society Oct, 2012 | Pubmed ID: 22926221
In vitro analysis of bone phenotypes in Col1a1 and Jagged1 mutant mice using a standardized osteoblast cell culture system.
Journal of bone and mineral metabolism May, 2013 | Pubmed ID: 23371561
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2013 | Pubmed ID: 23426636
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.
The Journal of biological chemistry Jun, 2013 | Pubmed ID: 23620591
Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice.
PloS one , 2013 | Pubmed ID: 23675505
Rapamycin extends murine lifespan but has limited effects on aging.
The Journal of clinical investigation Aug, 2013 | Pubmed ID: 23863708
Highly efficient targeted mutagenesis in mice using TALENs.
Genetics Nov, 2013 | Pubmed ID: 23979585
Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.
Nature protocols Dec, 2013 | Pubmed ID: 24177293
An RNAi-based approach to down-regulate a gene family in vivo.
PloS one , 2013 | Pubmed ID: 24265806
Wnt1-regulated genetic networks in midbrain dopaminergic neuron development.
Journal of molecular cell biology Feb, 2014 | Pubmed ID: 24326514
Efficient isolation of pure and functional mitochondria from mouse tissues using automated tissue disruption and enrichment with anti-TOM22 magnetic beads.
PloS one , 2013 | Pubmed ID: 24349272
Generation of targeted mouse mutants by embryo microinjection of TALENs.
Methods (San Diego, Calif.) Aug, 2014 | Pubmed ID: 24418396
Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon.
Genome research Apr, 2014 | Pubmed ID: 24642863
A robust and reliable non-invasive test for stress responsivity in mice.
Frontiers in behavioral neuroscience , 2014 | Pubmed ID: 24782732
High-throughput phenotypic assessment of cardiac physiology in four commonly used inbred mouse strains.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Aug, 2014 | Pubmed ID: 24788387
Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.
PloS one , 2014 | Pubmed ID: 24896637
Pleiotropic functions for transcription factor zscan10.
PloS one , 2014 | Pubmed ID: 25111779
Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain.
Database : the journal of biological databases and curation , 2014 | Pubmed ID: 25145340
Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.
FEBS open bio , 2015 | Pubmed ID: 25685662
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.
Nature biotechnology May, 2015 | Pubmed ID: 25803306
Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.
The Journal of biological chemistry Jun, 2015 | Pubmed ID: 25922076
A WNT1-regulated developmental gene cascade prevents dopaminergic neurodegeneration in adult En1(+/-) mice.
Neurobiology of disease Oct, 2015 | Pubmed ID: 26049140
MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation.
Developmental cell Jun, 2015 | Pubmed ID: 26051541
Design and Generation of Gene-Targeting Vectors.
Current protocols in mouse biology Mar, 2011 | Pubmed ID: 26068993
Development of an intein-mediated split-Cas9 system for gene therapy.
Nucleic acids research Jul, 2015 | Pubmed ID: 26082496
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
Nature genetics Jul, 2015 | Pubmed ID: 26214591
Beyond knockouts: the International Knockout Mouse Consortium delivers modular and evolving tools for investigating mammalian genes.
Mammalian genome : official journal of the International Mammalian Genome Society Oct, 2015 | Pubmed ID: 26340938
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
PloS one , 2015 | Pubmed ID: 26352593
Dickkopf 3 Promotes the Differentiation of a Rostrolateral Midbrain Dopaminergic Neuronal Subset In Vivo and from Pluripotent Stem Cells In Vitro in the Mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2015 | Pubmed ID: 26424886
Genome Editing in Mice Using TALE Nucleases.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 26443225
Conditional Reduction of Adult Born Doublecortin-Positive Neurons Reversibly Impairs Selective Behaviors.
Frontiers in behavioral neuroscience , 2015 | Pubmed ID: 26617501
Assessing Cognition in Mice.
Current protocols in mouse biology Dec, 2015 | Pubmed ID: 26629775
Differences in the spatiotemporal expression and epistatic gene regulation of the mesodiencephalic dopaminergic precursor marker PITX3 during chicken and mouse development.
Development (Cambridge, England) Feb, 2016 | Pubmed ID: 26755703
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice.
Journal of breath research Feb, 2016 | Pubmed ID: 26860833
Diversity matters - heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease.
Journal of neurochemistry 10, 2016 | Pubmed ID: 27206718
CRFR1 in AgRP Neurons Modulates Sympathetic Nervous System Activity to Adapt to Cold Stress and Fasting.
Cell metabolism Jun, 2016 | Pubmed ID: 27211900
Animal Models Are Valid to Uncover Disease Mechanisms.
PLoS genetics 05, 2016 | Pubmed ID: 27227339
Viable Ednra (Y129F) mice feature human mandibulofacial dysostosis with alopecia (MFDA) syndrome due to the homologue mutation.
Mammalian genome : official journal of the International Mammalian Genome Society Dec, 2016 | Pubmed ID: 27671791
Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.
Development (Cambridge, England) 11, 2016 | Pubmed ID: 27729409
The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations.
G3 (Bethesda, Md.) Dec, 2016 | Pubmed ID: 27815347
Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice.
Purinergic signalling 06, 2017 | Pubmed ID: 27858314
Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.
Nucleic acids research Apr, 2017 | Pubmed ID: 27923998
Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis.
Neuron Feb, 2017 | Pubmed ID: 28111078
Gene editing in mouse zygotes using the CRISPR/Cas9 system.
Methods (San Diego, Calif.) 05, 2017 | Pubmed ID: 28263886
Control of gene editing by manipulation of DNA repair mechanisms.
Mammalian genome : official journal of the International Mammalian Genome Society Aug, 2017 | Pubmed ID: 28374058
Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss.
Acta neuropathologica 08, 2017 | Pubmed ID: 28409281
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
The EMBO journal 07, 2017 | Pubmed ID: 28559417
The pathogenic LRRK2 R1441C mutation induces specific deficits modeling the prodromal phase of Parkinson's disease in the mouse.
Neurobiology of disease Sep, 2017 | Pubmed ID: 28576705
Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.
Nature genetics Aug, 2017 | Pubmed ID: 28650483
Fgf9 Mutation Alters Information Processing and Social Memory in Mice.
Molecular neurobiology Jun, 2018 | Pubmed ID: 28695538
Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.
Nature communications Jul, 2017 | Pubmed ID: 28761067
Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic.
Behavioural brain research 10, 2018 | Pubmed ID: 28966146
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Nature communications 10, 2017 | Pubmed ID: 29026089
Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2017 | Pubmed ID: 29079688
Lifetime study in mice after acute low-dose ionizing radiation: a multifactorial study with special focus on cataract risk.
Radiation and environmental biophysics 05, 2018 | Pubmed ID: 29327260
Identification of genetic elements in metabolism by high-throughput mouse phenotyping.
Nature communications 01, 2018 | Pubmed ID: 29348434
Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data.
PLoS biology Apr, 2018 | Pubmed ID: 29659570
Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy.
Cell death & disease Jul, 2018 | Pubmed ID: 29988147
The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
Molecular neurodegeneration 09, 2018 | Pubmed ID: 30185230
A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.
Biochimica et biophysica acta. Molecular basis of disease Dec, 2018 | Pubmed ID: 30557699
Christopher T. Breunig1,2,
Andrea M. Neuner1,2,
Jessica Giehrl-Schwab3,
Wolfgang Wurst3,
Magdalena Götz2,4,
Stefan H. Stricker1,2
1MCN Junior Research Group, Munich Center for Neurosciences, Ludwig Maximilian Universitat, BioMedical Center,
2Institute of Stem Cell Research, Helmholtz Zentrum, German Research Center for Environmental Health,
3Institute of Developmental Genetics, Helmholtz Zentrum, German Research Center for Environmental Health,
4Physiological Genomics, Ludwig Maximilian Universitat, BioMedical Center
SOBRE A JoVE
Copyright © 2024 MyJoVE Corporation. Todos os direitos reservados