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Department of Biochemistry,
Cellular and Molecular Biology,
Department of Biochemistry, Cellular and Molecular Biology
Elizabeth E. Howell has not added Biography.
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Intact protein analysis for site-directed mutagenesis overexpression products: plasmid-encoded R67 dihydrofolate reductase.
Analytical biochemistry Jun, 2002 | Pubmed ID: 12018947
Breaking symmetry: mutations engineered into R67 dihydrofolate reductase, a D2 symmetric homotetramer possessing a single active site pore.
Biochemistry Dec, 2002 | Pubmed ID: 12501195
Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase.
Biochemistry Sep, 2003 | Pubmed ID: 12962480
NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity.
Biochemistry Sep, 2003 | Pubmed ID: 14503865
Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis.
Biochemistry Jun, 2004 | Pubmed ID: 15182183
Role of Lys-32 residues in R67 dihydrofolate reductase probed by asymmetric mutations.
The Journal of biological chemistry Nov, 2004 | Pubmed ID: 15333636
"Catch 222," the effects of symmetry on ligand binding and catalysis in R67 dihydrofolate reductase as determined by mutations at Tyr-69.
The Journal of biological chemistry Nov, 2004 | Pubmed ID: 15333637
Searching sequence space: two different approaches to dihydrofolate reductase catalysis.
Chembiochem : a European journal of chemical biology Apr, 2005 | Pubmed ID: 15812782
Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate.
Acta crystallographica. Section D, Biological crystallography May, 2005 | Pubmed ID: 15858267
Calorimetric studies of ligand binding in R67 dihydrofolate reductase.
Biochemistry Sep, 2005 | Pubmed ID: 16156655
Effects of temperature and viscosity on R67 dihydrofolate reductase catalysis.
Biochemistry May, 2006 | Pubmed ID: 16716070
Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2006 | Pubmed ID: 17130456
A preference for edgewise interactions between aromatic rings and carboxylate anions: the biological relevance of anion-quadrupole interactions.
The journal of physical chemistry. B Jul, 2007 | Pubmed ID: 17580852
Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry Dec, 2007 | Pubmed ID: 18052202
R67, the other dihydrofolate reductase: rational design of an alternate active site configuration.
Biochemistry Jan, 2008 | Pubmed ID: 18085798
A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase.
The Journal of biological chemistry Feb, 2008 | Pubmed ID: 18086667
Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes.
Chemphyschem : a European journal of chemical physics and physical chemistry May, 2008 | Pubmed ID: 18444258
The effect of electrostatic shielding on H tunneling in R67 dihydrofolate reductase.
Chembiochem : a European journal of chemical biology Nov, 2009 | Pubmed ID: 19774544
Radical redesign of a tandem array of four R67 dihydrofolate reductase genes yields a functional, folded protein possessing 45 substitutions.
Biochemistry Aug, 2010 | Pubmed ID: 20684560
The tail wagging the dog: insights into catalysis in R67 dihydrofolate reductase.
Biochemistry Oct, 2010 | Pubmed ID: 20795731
A survey of aspartate-phenylalanine and glutamate-phenylalanine interactions in the protein data bank: searching for anion-Ï€ pairs.
Biochemistry Apr, 2011 | Pubmed ID: 21366334
Thermodynamics and solvent effects on substrate and cofactor binding in Escherichia coli chromosomal dihydrofolate reductase.
Biochemistry May, 2011 | Pubmed ID: 21462996
University of Tennessee
Michael R. Duff, Jr.1,
Jordan Grubbs1,
Elizabeth E. Howell1
1Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee
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