Michael Kharas

The avian chB6 alloantigen induces apoptosis in DT40 B cells.

Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells.

Optimal B-cell proliferation requires phosphoinositide 3-kinase-dependent inactivation of FOXO transcription factors.

ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors.

S6 kinase 2 potentiates interleukin-3-driven cell proliferation.

KLF4 suppresses transformation of pre-B cells by ABL oncogenes.

Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase.

T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

Measuring phosphorylated Akt and other phosphoinositide 3-kinase-regulated phosphoproteins in primary lymphocytes.

KLF4 is a FOXO target gene that suppresses B cell proliferation.

Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera.

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models.

Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis.

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.

Akt: a double-edged sword for hematopoietic stem cells.

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells.

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.

From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond.

The Lin28/let-7 axis regulates glucose metabolism.