Department of Anesthesiology
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Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
Proceedings of the National Academy of Sciences of the United States of America Aug, 1998 | Pubmed ID: 9707614
RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts.
Molecular and cellular biology Nov, 1999 | Pubmed ID: 10523657
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery.
Nature medicine Aug, 2002 | Pubmed ID: 12134142
Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies.
Trends in cardiovascular medicine Feb, 2004 | Pubmed ID: 15030789
Return of calcium: manipulating intracellular calcium to prevent cardiac pathologies.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2004 | Pubmed ID: 15079064
Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition.
American journal of physiology. Heart and circulatory physiology Mar, 2005 | Pubmed ID: 15528225
Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load.
The Journal of clinical investigation May, 2005 | Pubmed ID: 15841206
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
Genes & development May, 2005 | Pubmed ID: 15870258
Molecular and functional signature of heart hypertrophy during pregnancy.
Circulation research Jun, 2005 | Pubmed ID: 15905459
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.
The Journal of cell biology Oct, 2005 | Pubmed ID: 16203857
JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes.
American journal of physiology. Heart and circulatory physiology Sep, 2006 | Pubmed ID: 16603688
Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth.
The Journal of biological chemistry Sep, 2006 | Pubmed ID: 16798733
Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
Journal of molecular and cellular cardiology Mar, 2007 | Pubmed ID: 17276456
A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.
Genes & development Apr, 2007 | Pubmed ID: 17374715
Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Circulation Aug, 2007 | Pubmed ID: 17646583
Mitogen-activated protein kinases in heart development and diseases.
Circulation Sep, 2007 | Pubmed ID: 17875982
Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury.
Journal of molecular and cellular cardiology Feb, 2009 | Pubmed ID: 19038262
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models.
Cell calcium Sep, 2009 | Pubmed ID: 19692123
Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy.
Journal of molecular and cellular cardiology Jun, 2010 | Pubmed ID: 20170660
Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice.
Journal of molecular and cellular cardiology Jul, 2010 | Pubmed ID: 20170663
Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte.
Circulation research Apr, 2010 | Pubmed ID: 20299663
MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
Circulation research Apr, 2010 | Pubmed ID: 20339119
An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.
Human molecular genetics Jul, 2010 | Pubmed ID: 20421363
Targeted disruption of Mapk14 (p38MAPKalpha) in granulosa cells and cumulus cells causes cell-specific changes in gene expression profiles that rescue COC expansion and maintain fertility.
Molecular endocrinology (Baltimore, Md.) Sep, 2010 | Pubmed ID: 20610537
Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy.
Circulation research Oct, 2010 | Pubmed ID: 20814020
Electrochemical properties and myocyte interaction of carbon nanotube microelectrodes.
Nano letters Nov, 2010 | Pubmed ID: 20954739
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.
Physiological reviews Oct, 2010 | Pubmed ID: 20959622
Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.
Human molecular genetics Feb, 2011 | Pubmed ID: 21088111
Proteomic insights into cardiac cell death and survival.
Proteomics. Clinical applications Jun, 2008 | Pubmed ID: 21136883
Restriction of big hearts by a small RNA.
Circulation research Feb, 2011 | Pubmed ID: 21293005
Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts.
Circulation research Dec, 2011 | Pubmed ID: 22034492
Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22199355
Systems-based approaches to cardiovascular disease.
Nature reviews. Cardiology Jan, 2012 | Pubmed ID: 22231714
p38γ activity is required for maintenance of slow skeletal muscle size.
Muscle & nerve Feb, 2012 | Pubmed ID: 22246884
Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth.
Molecular & cellular proteomics : MCP Jan, 2012 | Pubmed ID: 22270000
Zebrafish as a model for cardiovascular development and disease.
Drug discovery today. Disease models , 2008 | Pubmed ID: 22275951
Prostaglandin E2 in remote control of myocardial remodeling.
Circulation Jun, 2012 | Pubmed ID: 22589382
Global impact of RNA splicing on transcriptome remodeling in the heart.
Journal of Zhejiang University. Science. B Aug, 2012 | Pubmed ID: 22843179
Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.
Mammalian genome : official journal of the International Mammalian Genome Society Oct, 2012 | Pubmed ID: 22892838
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome.
Development (Cambridge, England) Dec, 2012 | Pubmed ID: 23095891
Nuclear phosphatase PPM1G in cellular survival and neural development.
Developmental dynamics : an official publication of the American Association of Anatomists Sep, 2013 | Pubmed ID: 23723158
Mechanism-based engineering against anthracycline cardiotoxicity.
Circulation Jul, 2013 | Pubmed ID: 23757311
Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes.
American journal of physiology. Heart and circulatory physiology Dec, 2013 | Pubmed ID: 24077883
Interferon regulatory factors in heart: stress response beyond inflammation.
Hypertension (Dallas, Tex. : 1979) Apr, 2014 | Pubmed ID: 24396026
Decoding the noncoding transcripts in human heart failure.
Circulation Mar, 2014 | Pubmed ID: 24429689
Blind dates in sciences: dealing with rejection in peer review.
Circulation research Mar, 2014 | Pubmed ID: 24625725
IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.
PloS one , 2014 | Pubmed ID: 25369058
Mapping genetic contributions to cardiac pathology induced by Beta-adrenergic stimulation in mice.
Circulation. Cardiovascular genetics Feb, 2015 | Pubmed ID: 25480693
Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.
Developmental cell Dec, 2014 | Pubmed ID: 25535917
Dawn of the Epi-LncRNAs: new path from Myheart.
Circulation research Jan, 2015 | Pubmed ID: 25593274
Genetics of common forms of heart failure: challenges and potential solutions.
Current opinion in cardiology May, 2015 | Pubmed ID: 25768955
Hypertrophic preconditioning: short-term tricks for long-term gain.
Circulation Apr, 2015 | Pubmed ID: 25820337
The Genetic Basis of Coronary Artery Disease and Atrial Fibrillation: A Search for Disease Mechanisms and Therapeutic Targets.
Journal of cardiothoracic and vascular anesthesia Oct, 2015 | Pubmed ID: 25976605
A H(a)rd Way to Adapt in Cardiac Hypertrophy.
Circulation research Aug, 2015 | Pubmed ID: 26316602
Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.
The Journal of biological chemistry Oct, 2015 | Pubmed ID: 26359501
Activation of Notch3 promotes pulmonary arterial smooth muscle cells proliferation via Hes1/p27Kip1 signaling pathway.
FEBS open bio , 2015 | Pubmed ID: 26380809
p38 MAP kinases in the heart.
Gene Jan, 2016 | Pubmed ID: 26390817
The elusive philosopher's stone in young blood.
Circulation research Nov, 2015 | Pubmed ID: 26541677
M1 of Murine Gamma-Herpesvirus 68 Induces Endoplasmic Reticulum Chaperone Production.
Scientific reports Nov, 2015 | Pubmed ID: 26615759
DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States.
Circulation research Mar, 2016 | Pubmed ID: 26838786
Positive Role for a Negative Calcineurin Regulator in Cardiac Hypertrophy.
Hypertension (Dallas, Tex. : 1979) May, 2016 | Pubmed ID: 27021013
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure.
Circulation May, 2016 | Pubmed ID: 27059949
The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits.
Journal of lipid research Jun, 2016 | Pubmed ID: 27099397
Photochemical Generation of Benzyl Cations That Selectively Cross-Link Guanine and Cytosine in DNA.
Organic letters 06, 2016 | Pubmed ID: 27191599
Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model.
PLoS genetics Jul, 2016 | Pubmed ID: 27385019
Decoding the Long Noncoding RNA During Cardiac Maturation: A Roadmap for Functional Discovery.
Circulation. Cardiovascular genetics Oct, 2016 | Pubmed ID: 27591185
The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.
Nature medicine 10, 2016 | Pubmed ID: 27618650
Branched chain amino acid metabolic reprogramming in heart failure.
Biochimica et biophysica acta 12, 2016 | Pubmed ID: 27639835
The chromatin-binding protein Smyd1 restricts adult mammalian heart growth.
American journal of physiology. Heart and circulatory physiology 11, 2016 | Pubmed ID: 27663768
Deconvolution of the Human Endothelial Transcriptome.
Cell systems Sep, 2016 | Pubmed ID: 27684186
Operationalizing Precision Cardiovascular Medicine: Three Innovations.
Circulation research 10, 2016 | Pubmed ID: 27737942
Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice.
Cell systems Jan, 2017 | Pubmed ID: 27866946
Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification.
Cell stem cell 02, 2017 | Pubmed ID: 27867037
A systems genetics approach identifies as a link between cardiomyocyte glucose utilization and hypertrophic response.
American journal of physiology. Heart and circulatory physiology Apr, 2017 | Pubmed ID: 28235788
Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction.
PloS one , 2017 | Pubmed ID: 28542617
A Path to Implement Precision Child Health Cardiovascular Medicine.
Frontiers in cardiovascular medicine , 2017 | Pubmed ID: 28620608
Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart.
The Journal of biological chemistry 08, 2017 | Pubmed ID: 28637870
High-Resolution Mapping of Chromatin Conformation in Cardiac Myocytes Reveals Structural Remodeling of the Epigenome in Heart Failure.
Circulation Oct, 2017 | Pubmed ID: 28802249
The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes.
eLife 08, 2017 | Pubmed ID: 28826496
Untangle a Broken Heart via Janus Kinase 1.
Circulation research 09, 2017 | Pubmed ID: 28860312
Wnt11 regulates cardiac chamber development and disease during perinatal maturation.
JCI insight 09, 2017 | Pubmed ID: 28878122
A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart.
JACC. Basic to translational science Mar, 2017 | Pubmed ID: 29057374
A personalized, multiomics approach identifies genes involved in cardiac hypertrophy and heart failure.
NPJ systems biology and applications , 2018 | Pubmed ID: 29507758
The serine/threonine-protein kinase/endoribonuclease IRE1α protects the heart against pressure overload-induced heart failure.
The Journal of biological chemistry 06, 2018 | Pubmed ID: 29769316
Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity.
American journal of physiology. Heart and circulatory physiology 09, 2018 | Pubmed ID: 29775411
Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.
Circulation 09, 2018 | Pubmed ID: 29950403
Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans.
G3 (Bethesda, Md.) 11, 2018 | Pubmed ID: 30201759
EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs.
Current gene therapy , 2018 | Pubmed ID: 30295189
Epigenomic regulation of heart failure: integrating histone marks, long noncoding RNAs, and chromatin architecture.
F1000Research , 2018 | Pubmed ID: 30416708
Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.
Circulation research Jan, 2019 | Pubmed ID: 30605412
RBFox2-miR-34a-Jph2 axis contributes to cardiac decompensation during heart failure.
Proceedings of the National Academy of Sciences of the United States of America 03, 2019 | Pubmed ID: 30867288
Epigenetics in dilated cardiomyopathy.
Current opinion in cardiology May, 2019 | Pubmed ID: 30973397
Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study.
The American journal of clinical nutrition Jun, 2019 | Pubmed ID: 31005973
Glucagon Receptor Antagonism Ameliorates Progression of Heart Failure.
JACC. Basic to translational science Apr, 2019 | Pubmed ID: 31061918
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.
Diabetes Sep, 2019 | Pubmed ID: 31167878
Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure.
JACC. Basic to translational science Jun, 2019 | Pubmed ID: 31312763
Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis.
Frontiers in cardiovascular medicine , 2019 | Pubmed ID: 31417910
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