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Michael Schramm

Institute for Medical Microbiology,
Immunology and Hygiene,
Faculty of Medicine and University Hospital Cologne,
Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne

University of Cologne

BIOGRAPHY

Michael Schramm is a junior group leader at the Institute for Medical Microbiology, Immunology and Hygiene of the University of Cologne and the University Hospital Cologne.

His research focuses on the innate immune response, in particular the regulation of antibacterial immunity by reactive oxygen species and the antibacterial activity of macrophages.

PUBLICATIONS

Fusogenicity of membranes: the impact of acid sphingomyelinase on innate immune responses.

Immunobiology , 2008 | Pubmed ID: 18406376

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.

Nature immunology Jul, 2009 | Pubmed ID: 19525969

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.

Nature Aug, 2009 | Pubmed ID: 19641494

Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells.

Journal of immunology (Baltimore, Md. : 1950) Aug, 2013 | Pubmed ID: 23842753

Riboflavin (vitamin B2 ) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes.

European journal of immunology Mar, 2014 | Pubmed ID: 24272050

Autophagy determines efficiency of liver-directed gene therapy with adeno-associated viral vectors.

Hepatology (Baltimore, Md.) 07, 2017 | Pubmed ID: 28318036

The β Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes.

Cell host & microbe Mar, 2018 | Pubmed ID: 29544096

LC3-associated phagocytosis initiated by integrin ITGAM-ITGB2/Mac-1 enhances immunity to Listeria monocytogenes.

Autophagy , 2018 | Pubmed ID: 29923444

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition.

Nature communications 02, 2019 | Pubmed ID: 30737374

Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO.

Science signaling 02, 2019 | Pubmed ID: 30755476

LC3-associated phagocytosis - The highway to hell for phagocytosed microbes.

Seminars in cell & developmental biology Apr, 2019 | Pubmed ID: 31029766

INSTITUTIONS

University of Cologne

JOVE ARTICLES

Highly Efficient Transfection of Primary Macrophages with In Vitro Transcribed mRNA

Marc Herb¹,

Alina Farid¹,

Alexander Gluschko¹,

Martin Krönke^1,2,3,4,

Michael Schramm¹

¹Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine and University Hospital Cologne, University of Cologne,

², Center for Molecular Medicine Cologne,

³, Cologne Cluster of Excellence on Cellular Stress Responses in Aging-associated Diseases (CECAD),

⁴, German Center for Infection Research (DZIF)

Immunology and Infection

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