Department of Immunohematology and Blood Transfusion
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Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models.
Cells 04, 2019 | Pubmed ID: 30959852
Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors.
The Journal of experimental medicine Mar, 1998 | Pubmed ID: 9480979
CD4 T cells and their role in antitumor immune responses.
The Journal of experimental medicine Mar, 1999 | Pubmed ID: 10049938
Immature dendritic cells acquire CD8(+) cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or -dependent stimuli.
The Journal of experimental medicine Jul, 2000 | Pubmed ID: 10880536
Differential influence on cytotoxic T lymphocyte epitope presentation by controlled expression of either proteasome immunosubunits or PA28.
The Journal of experimental medicine Aug, 2000 | Pubmed ID: 10952718
Efficient identification of novel HLA-A(*)0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis.
The Journal of experimental medicine Jan, 2001 | Pubmed ID: 11136822
Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells.
The Journal of experimental medicine Sep, 2001 | Pubmed ID: 11535633
Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells.
The Journal of cell biology Oct, 2001 | Pubmed ID: 11581285
Antigen-antibody immune complexes empower dendritic cells to efficiently prime specific CD8+ CTL responses in vivo.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2002 | Pubmed ID: 11859111
Identification of a novel HLA-B60-restricted T cell epitope of the minor histocompatibility antigen HA-1 locus.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2002 | Pubmed ID: 12218130
Antitumor efficacy of wild-type p53-specific CD4(+) T-helper cells.
Cancer research Nov, 2002 | Pubmed ID: 12414646
Effective therapeutic anticancer vaccines based on precision guiding of cytolytic T lymphocytes.
Immunological reviews Oct, 2002 | Pubmed ID: 12445291
The minor histocompatibility antigen HA-3 arises from differential proteasome-mediated cleavage of the lymphoid blast crisis (Lbc) oncoprotein.
Blood Jul, 2003 | Pubmed ID: 12663445
Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells.
Transplantation Dec, 2003 | Pubmed ID: 14702533
New chelation strategy allows for quick and clean 99mTc-labeling of synthetic peptides.
Nuclear medicine and biology Aug, 2004 | Pubmed ID: 15246374
Gamma irradiation or CD4+-T-cell depletion causes reactivation of latent Salmonella enterica serovar Typhimurium infection in C3H/HeN mice.
Infection and immunity May, 2005 | Pubmed ID: 15845491
Differential expression regulation of the alpha and beta subunits of the PA28 proteasome activator in mature dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2005 | Pubmed ID: 15944286
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2005 | Pubmed ID: 16339897
Murine Fc receptors for IgG are redundant in facilitating presentation of immune complex derived antigen to CD8+ T cells in vivo.
Molecular immunology May, 2006 | Pubmed ID: 16513171
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.
Nature medicine Apr, 2006 | Pubmed ID: 16550190
Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2006 | Pubmed ID: 16585547
Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II-restricted CD4+ T cells upon immune-complex uptake in vivo.
Immunology Dec, 2006 | Pubmed ID: 16995881
A novel role of complement factor C1q in augmenting the presentation of antigen captured in immune complexes to CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2007 | Pubmed ID: 17548593
Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2009 | Pubmed ID: 19342659
Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2009 | Pubmed ID: 19346487
DC-induced CD8(+) T-cell response is inhibited by MHC class II-dependent DX5(+)CD4(+) Treg.
European journal of immunology Jul, 2009 | Pubmed ID: 19544486
Effective CD8(+) T cell priming and tumor protection by enterotoxin B subunit-conjugated peptides targeted to dendritic cells.
Vaccine Aug, 2009 | Pubmed ID: 19576942
Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t.
Chemistry & biology Aug, 2010 | Pubmed ID: 20797608
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Nature immunology Jan, 2011 | Pubmed ID: 21151101
Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors.
PloS one Feb, 2011 | Pubmed ID: 21347234
Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.
Journal of autoimmunity Nov, 2011 | Pubmed ID: 21636247
The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2011 | Pubmed ID: 21724994
Circulating specific antibodies enhance systemic cross-priming by delivery of complexed antigen to dendritic cells in vivo.
European journal of immunology Mar, 2012 | Pubmed ID: 22488363
Fcγ receptor IIb strongly regulates Fcγ receptor-facilitated T cell activation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2012 | Pubmed ID: 22649202
Vaccine-induced effector-memory CD8+ T cell responses predict therapeutic efficacy against tumors.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2012 | Pubmed ID: 22914049
Efficient ex vivo induction of T cells with potent anti-tumor activity by protein antigen encapsulated in nanoparticles.
Cancer immunology, immunotherapy : CII Jul, 2013 | Pubmed ID: 23613147
Prospects of combinatorial synthetic peptide vaccine-based immunotherapy against cancer.
Seminars in immunology Apr, 2013 | Pubmed ID: 23706598
Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2013 | Pubmed ID: 23788581
Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation.
European journal of immunology Oct, 2013 | Pubmed ID: 23836147
New role of signal peptide peptidase to liberate C-terminal peptides for MHC class I presentation.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2013 | Pubmed ID: 24048903
Local immunomodulation for cancer therapy: Providing treatment where needed.
Oncoimmunology Nov, 2013 | Pubmed ID: 24490127
Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer.
Vaccine Mar, 2014 | Pubmed ID: 24508038
IgG-mediated anaphylaxis to a synthetic long peptide vaccine containing a B cell epitope can be avoided by slow-release formulation.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2014 | Pubmed ID: 24813207
Ovalbumin-coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Oct, 2014 | Pubmed ID: 24820032
Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire.
Molecular immunology Nov, 2014 | Pubmed ID: 24983205
Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: a comparative study.
Journal of controlled release : official journal of the Controlled Release Society Oct, 2014 | Pubmed ID: 25068703
Enhanced cross-presentation and improved CD8+ T cell responses after mannosylation of synthetic long peptides in mice.
PloS one , 2014 | Pubmed ID: 25137039
FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2014 | Pubmed ID: 25355925
Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: In vivo tracking and evaluation of antigen-specific CD8(+) T cell immune response.
Biomaterials Jan, 2015 | Pubmed ID: 25453974
CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses.
Biomaterials Feb, 2015 | Pubmed ID: 25465442
Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death.
Clinical cancer research : an official journal of the American Association for Cancer Research Feb, 2015 | Pubmed ID: 25501579
Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule.
Oncoimmunology , 2014 | Pubmed ID: 25610736
Polymeric nanoparticles for co-delivery of synthetic long peptide antigen and poly IC as therapeutic cancer vaccine formulation.
Journal of controlled release : official journal of the Controlled Release Society Apr, 2015 | Pubmed ID: 25660830
The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells.
Immunity May, 2015 | Pubmed ID: 25979419
Polymeric microparticles for sustained and local delivery of antiCD40 and antiCTLA-4 in immunotherapy of cancer.
Biomaterials Aug, 2015 | Pubmed ID: 25993015
Therapeutic cancer vaccines.
The Journal of clinical investigation Sep, 2015 | Pubmed ID: 26214521
The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion.
eLife Aug, 2015 | Pubmed ID: 26263500
Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research Mar, 2016 | Pubmed ID: 26546617
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
The Journal of clinical investigation Feb, 2016 | Pubmed ID: 26784543
Vaccines for established cancer: overcoming the challenges posed by immune evasion.
Nature reviews. Cancer Apr, 2016 | Pubmed ID: 26965076
Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells.
eLife Mar, 2016 | Pubmed ID: 26999763
TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients.
Oncotarget Oct, 2016 | Pubmed ID: 27564262
The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes.
ACS chemical biology 11, 2016 | Pubmed ID: 27704768
Strong in vivo antitumor responses induced by an antigen immobilized in nanogels via reducible bonds.
Nanoscale Dec, 2016 | Pubmed ID: 27748778
Self-Assembling Peptide Epitopes as Novel Platform for Anticancer Vaccination.
Molecular pharmaceutics 05, 2017 | Pubmed ID: 28088862
C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes.
Journal of immunology (Baltimore, Md. : 1950) 06, 2017 | Pubmed ID: 28432146
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy.
Oncoimmunology , 2017 | Pubmed ID: 28507803
CD4 T Cell and NK Cell Interplay Key to Regression of MHC Class I Tumors upon TLR7/8 Agonist Therapy.
Cancer immunology research 08, 2017 | Pubmed ID: 28637878
PD-L1 immune suppression in cancer: Tumor cells or host cells?
Oncoimmunology , 2017 | Pubmed ID: 28811961
Photodynamic-Immune Checkpoint Therapy Eradicates Local and Distant Tumors by CD8 T Cells.
Cancer immunology research 10, 2017 | Pubmed ID: 28851692
Linking T cell epitopes to a common linear B cell epitope: A targeting and adjuvant strategy to improve T cell responses.
Molecular immunology 01, 2018 | Pubmed ID: 29175591
A Restricted Role for FcγR in the Regulation of Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950) 04, 2018 | Pubmed ID: 29523656
Sustained cross-presentation capacity of murine splenic dendritic cell subsets in vivo.
European journal of immunology 07, 2018 | Pubmed ID: 29676785
Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes.
ACS chemical biology 06, 2018 | Pubmed ID: 29733186
Formation of Immune Complexes with a Tetanus-Derived B Cell Epitope Boosts Human T Cell Responses to Covalently Linked Peptides in an Ex Vivo Blood Loop System.
Journal of immunology (Baltimore, Md. : 1950) 07, 2018 | Pubmed ID: 29752315
Approaches to Improve Chemically Defined Synthetic Peptide Vaccines.
Frontiers in immunology , 2018 | Pubmed ID: 29755468
Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences.
Journal of controlled release : official journal of the Controlled Release Society 09, 2018 | Pubmed ID: 30008371
FcγRI expression on macrophages is required for antibody-mediated tumor protection by cytomegalovirus-based vaccines.
Oncotarget Jun, 2018 | Pubmed ID: 30034625
FcγR interaction is not required for effective anti-PD-L1 immunotherapy but can add additional benefit depending on the tumor model.
International journal of cancer 01, 2019 | Pubmed ID: 30259976
High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy.
Journal of immunology (Baltimore, Md. : 1950) 12, 2018 | Pubmed ID: 30397036
: A workflow for visual and quantitative analysis of flow and mass cytometry data to discover immune signatures and correlations.
Computational and structural biotechnology journal , 2018 | Pubmed ID: 30450167
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy.
JCI insight 12, 2018 | Pubmed ID: 30518694
Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication.
Journal for immunotherapy of cancer 12, 2018 | Pubmed ID: 30541631
A Dual-Color Bioluminescence Reporter Mouse for Simultaneous Imaging of T Cell Localization and Function.
Frontiers in immunology , 2018 | Pubmed ID: 30671062
Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells.
Bioconjugate chemistry Apr, 2019 | Pubmed ID: 30865430
Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7.
Bioorganic & medicinal chemistry letters Jun, 2019 | Pubmed ID: 30952595
PD-L1 blockade engages tumor-infiltrating lymphocytes to co-express targetable activating and inhibitory receptors.
Journal for immunotherapy of cancer Aug, 2019 | Pubmed ID: 31412943
Effective chemoimmunotherapy by co-delivery of doxorubicin and immune adjuvants in biodegradable nanoparticles.
Theranostics , 2019 | Pubmed ID: 31588231
A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control.
Oncoimmunology , 2019 | Pubmed ID: 31646082
Cationic synthetic long peptides-loaded nanogels: An efficient therapeutic vaccine formulation for induction of T-cell responses.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2019 | Pubmed ID: 31672626
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