Lei Chen

Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature.

Nicotine attenuates iNOS expression and contributes to neuroprotection in a compressive model of spinal cord injury.

An integrative multi-platform analysis for discovering biomarkers of osteosarcoma.

Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation.

Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression.

Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke.

HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits.

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study.

Diffuse optical monitoring of repeated cerebral ischemia in mice.

Proinflammatory adhesion molecules facilitate polychlorinated biphenyl-mediated enhancement of brain metastasis formation.

Interleukin 2 gene polymorphisms are associated with non-Hodgkin lymphoma.

Autophagy is involved in nanoalumina-induced cerebrovascular toxicity.

Cerebrovascular toxicity of PCB153 is enhanced by binding to silica nanoparticles.

T-cell immunoglobulin- and mucin-domain-containing molecule 3 genetic variants and HIV+ non-Hodgkin lymphomas.

MiR-15a is underexpressed and inhibits the cell cycle by targeting CCNE1 in breast cancer.

MiRNA-497 regulates cell growth and invasion by targeting cyclin E1 in breast cancer.

Genetic modification of mesenchymal stem cells in spinal cord injury repair strategies.

miR-96 promotes tumor proliferation and invasion by targeting RECK in breast cancer.

MicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer.

PPAR agonist-mediated protection against HIV Tat-induced cerebrovascular toxicity is enhanced in MMP-9-deficient mice.

Luminescent hybrid materials based on zeolite L crystals and lanthanide complexes: host-guest assembly and ultraviolet-visible excitation.

Transplantation of bone marrow mesenchymal stem cells pretreated with valproic acid in rats with an acute spinal cord injury.

Extraction of diffuse correlation spectroscopy flow index by integration of Nth-order linear model with Monte Carlo simulation.

Screening of surface markers on rat intestinal mucosa microfold cells by using laser capture microdissection combined with protein chip technology.

Alterations of microRNAs are associated with impaired growth of MCF-7 breast cancer cells induced by inhibition of casein kinase 2.

Multi-component assembly and luminescence tuning of lanthanide hybrids based with both zeolite L/A and SBA-15 through two organically grafted linkers.

Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis.

Multi-component lanthanide hybrids based on zeolite A/L and zeolite A/L-polymers for tunable luminescence.

Human umbilical cord and dental pulp-derived mesenchymal stem cells: biological characteristics and potential roles in vitro and in vivo.

The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation.

Regulation of MET-mediated proliferation of thyroid carcinoma cells by miR-449b.

Novel multi-component hybrids through double luminescent lanthanide unit functionalized zeolite L and titania.

Ultradispersed Palladium Nanoparticles in Three-Dimensional Dendritic Mesoporous Silica Nanospheres: Toward Active and Stable Heterogeneous Catalysts.

Type I Interferons Triggered through the Toll-Like Receptor 3-TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice.

Silencing of DUSP6 gene by RNAi-mediation inhibits proliferation and growth in MDA-MB-231 breast cancer cells: an in vitro study.

The clinical effect of percutaneous kyphoplasty for the treatment of multiple osteoporotic vertebral compression fractures and the prevention of new vertebral fractures.

Effectiveness of Intravitreal Injection of Ranibizumab for Neovascular Age-Related Macular Degeneration with Serous Pigment Epithelial Detachment.

Transcriptional regulator PrqR plays a negative role in glucose metabolism and oxidative stress acclimation in Synechocystis sp. PCC 6803.

An Alternative Approach for Registration of High-Resolution Satellite Optical Imagery and ICESat Laser Altimetry Data.

Near-Infrared-Activated Upconversion Nanoprobes for Sensitive Endogenous Zn Detection and Selective On-Demand Photodynamic Therapy.

miR-29b contributes to multiple types of muscle atrophy.

Preliminary Experience of Nontransecting Urethroplasty for Pelvic Fracture-related Urethral Injury.

Targeted gene panel sequencing prenatally detects two novel mutations of DYNC2H1 in a fetus with increased biparietal diameter and polyhydramnios.

Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls.

OTUB1 protein suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR.

Associations of IL-1, 6, and 10 Gene Polymorphisms with Susceptibility to Recurrent Aphthous Stomatitis: Insights from a Meta-Analysis.

Identification of aberrant circulating miRNAs in Parkinson's disease plasma samples.

[Therapeutic effect of Jinghuosu on oligospermia and asthenospermia.].

miR-519a enhances chemosensitivity and promotes autophagy in glioblastoma by targeting STAT3/Bcl2 signaling pathway.

Unbiased transcriptomic analyses reveal distinct effects of immune deficiency in CNS function with and without injury.

SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.

Integrated analysis of key mRNAs and lncRNAs in osteoarthritis.

Ubiquitination of Rheb governs growth factor-induced mTORC1 activation.

Erlotinib versus gemcitabine/cisplatin in Chinese patients with EGFR mutation-positive advanced non-small-cell lung cancer: Crossover extension and post-hoc analysis of the ENSURE study.

Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer.

Anti-tumor activity and mechanism of oligoclonal hepatocellular carcinoma tumor-infiltrating lymphocytes and .

Noninvasive noncontact speckle contrast diffuse correlation tomography of cerebral blood flow in rats.

Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma.

Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke.

A Wearable Fiberless Optical Sensor for Continuous Monitoring of Cerebral Blood Flow in Mice.

Heat shock cognate protein 70 promotes the differentiation of C2C12 myoblast and targets Yin Yang 1.

Is the result of modified Allen's test still accurate after endoscopic thoracic sympathectomy?

The role of ubiquitination in tumorigenesis and targeted drug discovery.

Exercise and Osteoarthritis.

PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.

Trajectory and Functional Analysis of PD-1 CD4CD8 T Cells in Hepatocellular Carcinoma by Single-Cell Cytometry and Transcriptome Sequencing.

Ulinastatin Promotes Regeneration of Peripheral Nerves After Sciatic Nerve Injury by Targeting let-7 microRNAs and Enhancing NGF Expression.

The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway.

MiR-506-3p suppresses papillary thyroid cancer cells tumorigenesis by targeting YAP1.

Comparison of Ivor Lewis and Sweet esophagectomy for middle and lower esophageal squamous cell carcinoma: A systematic review and pooled analysis.

The identification and functional analysis of CD8+PD-1+CD161+ T cells in hepatocellular carcinoma.

Inhibition of lncRNA MAAT Controls Multiple Types of Muscle Atrophy by cis- and trans-Regulatory Actions.

Inhibition of the sodium-glucose co-transporter SGLT2 by canagliflozin ameliorates diet-induced obesity by increasing intra-adipose sympathetic innervation.

Adverse Outcomes Associated With Corticosteroid Use in Critical COVID-19: A Retrospective Multicenter Cohort Study.

Facile Synthesis of Hollow MnO Nanoparticles for Reactive Oxygen Species Scavenging in Osteoarthritis.

Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values.

Myelocytomatosis-Protein Arginine N-Methyltransferase 5 Axis Defines the Tumorigenesis and Immune Response in Hepatocellular Carcinoma.

The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases.

Simultaneous Vascular Reconstruction and Cervical Anastomosis in McKeown Esophagectomy.

Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure.

Calibration and measurement of mitochondrial pH in intact adult rat cardiomyocytes.

Single-Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids.

MA Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.

Discovery of a Carbamoyl Phosphate Synthetase 1-Deficient HCC Subtype With Therapeutic Potential Through Integrative Genomic and Experimental Analysis.

Comparison of k-wire insertion using oscillatory and unidirectional drilling modes under constant thrust force.

The effect of biliary obstruction, biliary drainage and bile reinfusion on bile acid metabolism and gut microbiota in mice.

Shape optimization of egg-shaped sewer pipes based on the nondominated sorting genetic algorithm (NSGA-II).

Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou).

Depletion of m A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin.

Single cell atlas for 11 non-model mammals, reptiles and birds.

Comprehensive analysis of spatial architecture in primary liver cancer.

BMPR1B Polymorphisms (rs1434536 and rs1970801) are Associated With Breast Cancer Susceptibility in Northwest Chinese Han Females: A Case-Control Study.

Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells.

Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease.

AKAP12 ameliorates liver injury via targeting PI3K/AKT/PCSK6 pathway.

PGC-1-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure.

Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats.

Levalbuterol albuterol for hospitalized patients with COPD in China: cost-utility and budget impact analysis.

Operation analysis of freeway mixed traffic flow based on catch-up coordination platoon.

Inhibition of mitochondrial superoxide promotes the development of hiPS-CMs during differentiation.

The immuno-therapeutic potential of miR-2392 in patients with hepatocellular carcinoma.

The Association Between Circulating Sex Hormones and Central Serous Chorioretinopathy: A Case-Control Study.

Cystine Induced-mTORC2 Activation through Promoting Sin1 Phosphorylation to Suppress Cancer Cell Ferroptosis.

Thymosin β4, a potential marker of malignancy and prognosis in hepatocellular carcinoma.

Secreted phosphoprotein 1 promotes angiogenesis of glioblastoma through upregulating PSMA expression via transcription factor HIF-1α.

Denosumab biosimilar (LY06006) in Chinese postmenopausal osteoporotic women: A randomized, double-blind, placebo-controlled, multicenter phase III study.

Accuracy and feasibility with AI-assisted OCT in retinal disorder community screening.