British Heart Foundation Cardiovascular Sciences Unit
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A novel type of deubiquitinating enzyme.
The Journal of biological chemistry Jun, 2003 | Pubmed ID: 12682062
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.
The Biochemical journal Mar, 2004 | Pubmed ID: 14748687
Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs.
Expert reviews in molecular medicine Jun, 2005 | Pubmed ID: 15967057
The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2006 | Pubmed ID: 16469848
Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov, 2007 | Pubmed ID: 17557931
Effect of shear stress on vascular inflammation and plaque development.
Current opinion in lipidology Oct, 2007 | Pubmed ID: 17885423
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling.
The Journal of biological chemistry Mar, 2008 | Pubmed ID: 18178551
KLF2-dependent, shear stress-induced expression of CD59: a novel cytoprotective mechanism against complement-mediated injury in the vasculature.
The Journal of biological chemistry May, 2008 | Pubmed ID: 18362151
Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy.
Cardiovascular research Aug, 2008 | Pubmed ID: 18375498
Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.
The Journal of biological chemistry Jul, 2008 | Pubmed ID: 18474597
Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.
Circulation research Sep, 2008 | Pubmed ID: 18723442
Hemodynamic parameters regulating vascular inflammation and atherosclerosis: a brief update.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie Oct, 2008 | Pubmed ID: 18757166
The A20 gene protects kidneys from ischaemia/reperfusion injury by suppressing pro-inflammatory activation.
Journal of molecular medicine (Berlin, Germany) Dec, 2008 | Pubmed ID: 18813897
Nur77: orphaned at birth but adopted by the nuclear factor kappaB signaling pathway.
Circulation research Mar, 2009 | Pubmed ID: 19325155
Induction of the cytoprotective enzyme heme oxygenase-1 by statins is enhanced in vascular endothelium exposed to laminar shear stress and impaired by disturbed flow.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19457866
Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2009 | Pubmed ID: 19729611
Perfusion of veins at arterial pressure increases the expression of KLF5 and cell cycle genes in smooth muscle cells.
Biochemical and biophysical research communications Jan, 2010 | Pubmed ID: 19958749
c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis.
Arteriosclerosis, thrombosis, and vascular biology Mar, 2010 | Pubmed ID: 20056910
Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium.
Free radical biology & medicine Apr, 2010 | Pubmed ID: 20083195
Role of nuclear factor kappaB in cardiovascular health and disease.
Clinical science (London, England : 1979) May, 2010 | Pubmed ID: 20175746
Smooth muscle cells in porcine vein graft intimal hyperplasia are derived from the local vessel wall.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology May-Jun, 2011 | Pubmed ID: 20537564
Inhibition of NF-κB signaling in human dendritic cells by the enteropathogenic Escherichia coli effector protein NleE.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2010 | Pubmed ID: 20833837
The transcription factor Erg inhibits vascular inflammation by repressing NF-kappaB activation and proinflammatory gene expression in endothelial cells.
Arteriosclerosis, thrombosis, and vascular biology Jan, 2011 | Pubmed ID: 20966395
Dexamethasone arterializes venous endothelial cells by inducing mitogen-activated protein kinase phosphatase-1: a novel antiinflammatory treatment for vein grafts?
Circulation Feb, 2011 | Pubmed ID: 21262999
Do miniaturized extracorporeal circuits confer significant clinical benefit without compromising safety? A meta-analysis of randomized controlled trials.
ASAIO journal (American Society for Artificial Internal Organs : 1992) May-Jun, 2011 | Pubmed ID: 21266906
Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation.
Circulation research Apr, 2011 | Pubmed ID: 21350211
The role of blood flow in determining the sites of atherosclerotic plaques.
F1000 medicine reports , 2011 | Pubmed ID: 21654925
Heme induces heme oxygenase 1 via Nrf2: role in the homeostatic macrophage response to intraplaque hemorrhage.
Arteriosclerosis, thrombosis, and vascular biology Nov, 2011 | Pubmed ID: 21868703
Targeting inhibitor of apoptosis proteins to block vascular inflammation.
Arteriosclerosis, thrombosis, and vascular biology Oct, 2011 | Pubmed ID: 21918207
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