Koji Okamoto

Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export.

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.

Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.

KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction.

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.

Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs.

Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.

Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.

Systematic exploration of cancer-associated microRNA through functional screening assays.

Differential expression of nanog1 and nanogp8 in colon cancer cells.

miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.

Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells.

Genome engineering of mammalian haploid embryonic stem cells using the Cas9/RNA system.

MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells.

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.

Short hairpin RNA library-based functional screening identified ribosomal protein L31 that modulates prostate cancer cell growth via p53 pathway.

MicroRNA Library-Based Functional Screening Identified Androgen-Sensitive miR-216a as a Player in Bicalutamide Resistance in Prostate Cancer.

Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.

TNIK inhibition abrogates colorectal cancer stemness.

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.

Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications.

Investigations in the possibility of early detection of colorectal cancer by gas chromatography/triple-quadrupole mass spectrometry.

Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer.

The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells.

Heterogeneity among -positive colon stem cells.

Proteasome 26S subunit PSMD1 regulates breast cancer cell growth through p53 protein degradation.

Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells.

Hormonal Regulation of Patient-Derived Endometrial Cancer Stem-like Cells Generated by Three-Dimensional Culture.

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression.

N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells.

ALDH-Dependent Glycolytic Activation Mediates Stemness and Paclitaxel Resistance in Patient-Derived Spheroid Models of Uterine Endometrial Cancer.

Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer.