Center for Integrated Protein Science (CIPS-M) and Center for Drug Research,
Department of Pharmacy,
Center for Integrated Protein Science (CIPS-M) and Center for Drug Research, Department of Pharmacy
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Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2000 | Pubmed ID: 10662822
Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12928435
Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2005 | Pubmed ID: 15634774
An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels.
The Journal of biological chemistry Apr, 2005 | Pubmed ID: 15644313
Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.
Investigative ophthalmology & visual science Apr, 2005 | Pubmed ID: 15790924
The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides.
The Journal of biological chemistry Jul, 2005 | Pubmed ID: 15923185
A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase.
The Journal of biological chemistry Oct, 2005 | Pubmed ID: 16079136
The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration.
Pflugers Archiv : European journal of physiology Sep, 2006 | Pubmed ID: 16715293
Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping.
The Journal of biological chemistry Nov, 2006 | Pubmed ID: 16980309
Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2006 | Pubmed ID: 17028172
Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2007 | Pubmed ID: 17724338
Function and dysfunction of CNG channels: insights from channelopathies and mouse models.
Molecular neurobiology Jun, 2007 | Pubmed ID: 17917115
Cyclic nucleotide-regulated cation channels.
The Journal of biological chemistry Apr, 2009 | Pubmed ID: 19054768
Cyclic nucleotide-gated channels.
Handbook of experimental pharmacology , 2009 | Pubmed ID: 19089328
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.
Pflugers Archiv : European journal of physiology Sep, 2009 | Pubmed ID: 19557428
Hyperpolarization-activated cation channels: from genes to function.
Physiological reviews Jul, 2009 | Pubmed ID: 19584315
Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19717559
Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.
The Journal of biological chemistry Jul, 2010 | Pubmed ID: 20495006
Grueneberg ganglion neurons are finely tuned cold sensors.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2010 | Pubmed ID: 20519530
Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2010 | Pubmed ID: 20628362
An olfactory subsystem that detects carbon disulfide and mediates food-related social learning.
Current biology : CB Aug, 2010 | Pubmed ID: 20637621
Planar patch clamp approach to characterize ionic currents from intact lysosomes.
Science signaling Dec, 2010 | Pubmed ID: 21139138
The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2011 | Pubmed ID: 21209198
The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.
PloS one Feb, 2011 | Pubmed ID: 21347269
HCN3 contributes to the ventricular action potential waveform in the murine heart.
Circulation research Oct, 2011 | Pubmed ID: 21903939
Exploring HCN channels as novel drug targets.
Nature reviews. Drug discovery Nov, 2011 | Pubmed ID: 22094868
Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia.
Advances in experimental medicine and biology , 2012 | Pubmed ID: 22183332
CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.
Investigative ophthalmology & visual science Mar, 2012 | Pubmed ID: 22247469
Role of TRPML and two-pore channels in endolysosomal cation homeostasis.
The Journal of pharmacology and experimental therapeutics Aug, 2012 | Pubmed ID: 22518024
Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP.
The Journal of biological chemistry Aug, 2012 | Pubmed ID: 22715094
Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.
Human molecular genetics Oct, 2012 | Pubmed ID: 22802073
The role of HCN channels in ventricular repolarization.
Trends in cardiovascular medicine Nov, 2011 | Pubmed ID: 22902068
Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4).
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22936811
Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.
Angewandte Chemie (International ed. in English) Oct, 2012 | Pubmed ID: 23037940
Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction.
Cellular and molecular life sciences : CMLS May, 2013 | Pubmed ID: 23269435
Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23382386
Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study.
Human molecular genetics Oct, 2013 | Pubmed ID: 23740940
Gene replacement therapy for retinal CNG channelopathies.
Molecular genetics and genomics : MGG Oct, 2013 | Pubmed ID: 23861024
cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2013 | Pubmed ID: 24027293
Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.
Human molecular genetics Mar, 2014 | Pubmed ID: 24163243
Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.
Advances in experimental medicine and biology , 2014 | Pubmed ID: 24664765
Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors.
Human molecular genetics Nov, 2014 | Pubmed ID: 24963162
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.
Nature communications Aug, 2014 | Pubmed ID: 25119295
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.
Nature communications Aug, 2014 | Pubmed ID: 25144390
Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Sep, 2015 | Pubmed ID: 25615882
Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.
Science (New York, N.Y.) Feb, 2015 | Pubmed ID: 25722412
Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.
Anesthesiology May, 2015 | Pubmed ID: 25782754
TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.
Cell reports Apr, 2015 | Pubmed ID: 25843715
Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia.
Human molecular genetics Jul, 2015 | Pubmed ID: 25855802
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
The EMBO journal Jul, 2015 | Pubmed ID: 25872774
Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice.
Scientific reports Jun, 2015 | Pubmed ID: 26029863
cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.
The Journal of biological chemistry Aug, 2015 | Pubmed ID: 26124274
Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.
Human molecular genetics Oct, 2015 | Pubmed ID: 26188004
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.
PloS one , 2015 | Pubmed ID: 26352593
Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.
Nature protocols Jan, 2016 | Pubmed ID: 26658468
Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.
Human molecular genetics Mar, 2016 | Pubmed ID: 26740549
In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors.
PLoS genetics Jan, 2016 | Pubmed ID: 26796962
HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.
PloS one , 2016 | Pubmed ID: 26807953
Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.
Human molecular genetics Mar, 2016 | Pubmed ID: 27033727
Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response.
Investigative ophthalmology & visual science 05, 2016 | Pubmed ID: 27152964
Gene therapy for achromatopsia.
The journal of gene medicine Mar, 2017 | Pubmed ID: 28095637
Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.
Cancer research 03, 2017 | Pubmed ID: 28108508
Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation.
Molecular therapy : the journal of the American Society of Gene Therapy 03, 2017 | Pubmed ID: 28143742
Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.
Human molecular genetics Jan, 2017 | Pubmed ID: 28365780
Recombinant tandem of pore-domains in a Weakly Inward rectifying K channel 2 (TWIK2) forms active lysosomal channels.
Scientific reports 04, 2017 | Pubmed ID: 28381826
From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.
Cell calcium 11, 2017 | Pubmed ID: 28457591
Endoplasmic reticulum (ER) Ca-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.
The Journal of biological chemistry 07, 2017 | Pubmed ID: 28495882
Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.
Scientific reports 05, 2017 | Pubmed ID: 28539581
Photopharmacological control of bipolar cells restores visual function in blind mice.
The Journal of clinical investigation Jun, 2017 | Pubmed ID: 28581442
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.
Nature protocols Aug, 2017 | Pubmed ID: 28726848
Small Molecules for Early Endosome-Specific Patch Clamping.
Cell chemical biology Jul, 2017 | Pubmed ID: 28732201
Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons.
Pain Oct, 2017 | Pubmed ID: 28767511
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.
Proceedings of the National Academy of Sciences of the United States of America 10, 2017 | Pubmed ID: 28923947
AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.
Molecular therapy : the journal of the American Society of Gene Therapy Dec, 2017 | Pubmed ID: 28970046
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.
BMC pharmacology & toxicology Oct, 2017 | Pubmed ID: 29035170
Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.
Investigative ophthalmology & visual science 11, 2017 | Pubmed ID: 29117317
Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human -Retinitis Pigmentosa.
Human gene therapy Dec, 2017 | Pubmed ID: 29212382
Gene Therapy Successfully Delays Degeneration in a Mouse Model of -Linked Retinitis Pigmentosa (RP43).
Human gene therapy Dec, 2017 | Pubmed ID: 29212391
Endolysosomal Cation Channels and Cancer-A Link with Great Potential.
Pharmaceuticals (Basel, Switzerland) Jan, 2018 | Pubmed ID: 29303993
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.
Frontiers in immunology , 2017 | Pubmed ID: 29354133
Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.
International journal of molecular sciences Mar, 2018 | Pubmed ID: 29518895
Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.
Cell death and differentiation 12, 2018 | Pubmed ID: 29666476
Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.
Investigative ophthalmology & visual science 04, 2018 | Pubmed ID: 29677353
Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial.
Human gene therapy. Clinical development 09, 2018 | Pubmed ID: 30187779
In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30324456
Optimized Subretinal Injection Technique for Gene Therapy Approaches.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30324458
The protein interaction networks of mucolipins and two-pore channels.
Biochimica et biophysica acta. Molecular cell research 07, 2019 | Pubmed ID: 30395881
Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.
The Journal of clinical investigation 12, 2018 | Pubmed ID: 30418171
Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.
JCI insight 05, 2019 | Pubmed ID: 31045576
HCN3 ion channels: roles in sensory neuronal excitability and pain.
The Journal of physiology 09, 2019 | Pubmed ID: 31290157
Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes.
Journal of pharmaceutical sciences 01, 2020 | Pubmed ID: 31639391
Enigmatic rhodopsin mutation creates an exceptionally strong splice acceptor site.
Human molecular genetics 01, 2020 | Pubmed ID: 31816042
Advancing Gene Therapy for PDE6A Retinitis Pigmentosa.
Advances in experimental medicine and biology , 2019 | Pubmed ID: 31884596
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.
Neuropharmacology 07, 2020 | Pubmed ID: 32272140
Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial.
JAMA ophthalmology 06, 2020 | Pubmed ID: 32352493
TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.
Proceedings of the National Academy of Sciences of the United States of America 07, 2020 | Pubmed ID: 32661165
Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation.
Molecular therapy. Nucleic acids Sep, 2020 | Pubmed ID: 32841912
A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.
Science advances Aug, 2020 | Pubmed ID: 32875106
cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells.
Nature communications 11, 2020 | Pubmed ID: 33144559
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