Martin Biel

Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina.

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.

Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.

An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels.

Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3.

The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides.

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase.

The enhancement of HCN channel instantaneous current facilitated by slow deactivation is regulated by intracellular chloride concentration.

Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping.

Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain.

Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium.

Function and dysfunction of CNG channels: insights from channelopathies and mouse models.

Cyclic nucleotide-regulated cation channels.

Cyclic nucleotide-gated channels.

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.

Hyperpolarization-activated cation channels: from genes to function.

Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels.

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.

Grueneberg ganglion neurons are finely tuned cold sensors.

Restoration of cone vision in the CNGA3-/- mouse model of congenital complete lack of cone photoreceptor function.

An olfactory subsystem that detects carbon disulfide and mediates food-related social learning.

Planar patch clamp approach to characterize ionic currents from intact lysosomes.

The glutamic acid-rich protein is a gating inhibitor of cyclic nucleotide-gated channels.

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.

HCN3 contributes to the ventricular action potential waveform in the murine heart.

Exploring HCN channels as novel drug targets.

Gene therapy restores missing cone-mediated vision in the CNGA3-/- mouse model of achromatopsia.

CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.

Role of TRPML and two-pore channels in endolysosomal cation homeostasis.

Regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel activity by cCMP.

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

The role of HCN channels in ventricular repolarization.

Complex regulation of voltage-dependent activation and inactivation properties of retinal voltage-gated Cav1.4 L-type Ca2+ channels by Ca2+-binding protein 4 (CaBP4).

Isotope-based analysis of modified tRNA nucleosides correlates modification density with translational efficiency.

Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction.

Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).

Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study.

Gene replacement therapy for retinal CNG channelopathies.

cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors.

A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications.

Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.

Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments.

TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.

Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3-/-/Nrl-/- mice, an all-cone model of CNGA3 achromatopsia.

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.

Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice.

cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.

Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology.

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors.

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response.

Gene therapy for achromatopsia.

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.

Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation.

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Recombinant tandem of pore-domains in a Weakly Inward rectifying K channel 2 (TWIK2) forms active lysosomal channels.

From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.

Endoplasmic reticulum (ER) Ca-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.

Photopharmacological control of bipolar cells restores visual function in blind mice.

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.

Small Molecules for Early Endosome-Specific Patch Clamping.

Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons.

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017.

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Toward Treating Human -Retinitis Pigmentosa.

Gene Therapy Successfully Delays Degeneration in a Mouse Model of -Linked Retinitis Pigmentosa (RP43).

Endolysosomal Cation Channels and Cancer-A Link with Great Potential.

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.

Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial.

In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy.

Optimized Subretinal Injection Technique for Gene Therapy Approaches.

The protein interaction networks of mucolipins and two-pore channels.

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.

Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.

HCN3 ion channels: roles in sensory neuronal excitability and pain.

Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes.

Enigmatic rhodopsin mutation creates an exceptionally strong splice acceptor site.

Advancing Gene Therapy for PDE6A Retinitis Pigmentosa.

Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.

Safety and Vision Outcomes of Subretinal Gene Therapy Targeting Cone Photoreceptors in Achromatopsia: A Nonrandomized Controlled Trial.

TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.

Antisense Oligonucleotide- and CRISPR-Cas9-Mediated Rescue of mRNA Splicing for a Deep Intronic CLRN1 Mutation.

A gene therapy for inherited blindness using dCas9-VPR-mediated transcriptional activation.

cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells.