Department of Molecular Biology
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Promoter scanning for transcription inhibition with DNA-binding polyamides.
Molecular and cellular biology Mar, 2002 | Pubmed ID: 11865052
Cyclin L is an RS domain protein involved in pre-mRNA splicing.
The Journal of biological chemistry Jul, 2002 | Pubmed ID: 11980906
Blocking transcription through a nucleosome with synthetic DNA ligands.
Journal of molecular biology Aug, 2002 | Pubmed ID: 12144782
Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands.
Journal of molecular biology Feb, 2003 | Pubmed ID: 12559907
RNA as a transcriptional activator.
Chemistry & biology Jul, 2003 | Pubmed ID: 12890529
Accessibility of nuclear chromatin by DNA binding polyamides.
Chemistry & biology Sep, 2003 | Pubmed ID: 14522056
Molecular recognition of the nucleosomal "supergroove".
Proceedings of the National Academy of Sciences of the United States of America May, 2004 | Pubmed ID: 15100411
Regulation of gene expression with pyrrole-imidazole polyamides.
Journal of biotechnology Aug, 2004 | Pubmed ID: 15288953
Arresting cancer proliferation by small-molecule gene regulation.
Chemistry & biology Nov, 2004 | Pubmed ID: 15556009
Nucleosomes in solution exist as a mixture of twist-defect states.
Journal of molecular biology Jan, 2005 | Pubmed ID: 15567414
Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains.
Chembiochem : a European journal of chemical biology Jan, 2005 | Pubmed ID: 15593070
Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides.
Biochemistry Mar, 2005 | Pubmed ID: 15766247
Induced fit and "lock and key" recognition of 5S RNA by zinc fingers of transcription factor IIIA.
Journal of molecular biology Mar, 2006 | Pubmed ID: 16405997
Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.
Nature chemical biology Feb, 2006 | Pubmed ID: 16415862
DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2006 | Pubmed ID: 16857735
A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate.
Cell cycle (Georgetown, Tex.) Jul, 2006 | Pubmed ID: 16861886
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.
Nature chemical biology Oct, 2006 | Pubmed ID: 16921367
Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates.
Nucleic acids research , 2007 | Pubmed ID: 17170006
Small molecules affecting transcription in Friedreich ataxia.
Pharmacology & therapeutics Nov, 2007 | Pubmed ID: 17826840
Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.
Molecular cancer therapeutics Apr, 2008 | Pubmed ID: 18413791
HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.
PloS one , 2008 | Pubmed ID: 18463734
Targeting specific gene by alkylating pyrrole-imidazole polyamides.
Nucleic acids symposium series (2004) , 2008 | Pubmed ID: 18776404
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2008 | Pubmed ID: 18829438
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.
The Journal of biological chemistry Dec, 2008 | Pubmed ID: 18953021
Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.
PloS one , 2008 | Pubmed ID: 18974832
Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.
Bioorganic & medicinal chemistry letters Jul, 2009 | Pubmed ID: 19362838
Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing.
Chemistry & biology Sep, 2009 | Pubmed ID: 19778726
Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes.
Bioorganic & medicinal chemistry Jan, 2010 | Pubmed ID: 19962902
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Nature chemical biology Jan, 2010 | Pubmed ID: 19966789
Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.
PloS one , 2010 | Pubmed ID: 20098685
Chemical biology meets biological chemistry minireview series.
The Journal of biological chemistry Apr, 2010 | Pubmed ID: 20147295
Development of histone deacetylase inhibitors as therapeutics for neurological disease.
Future neurology Nov, 2009 | Pubmed ID: 20177429
Friedreich's ataxia induced pluripotent stem cells model intergenerational GAAâ‹…TTC triplet repeat instability.
Cell stem cell Nov, 2010 | Pubmed ID: 21040903
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.
Cell stem cell Jan, 2011 | Pubmed ID: 21211785
Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model.
Neurobiology of disease Jun, 2011 | Pubmed ID: 21397024
Introduction to the thematic minireview series on epigenetics.
The Journal of biological chemistry May, 2011 | Pubmed ID: 21454488
Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases.
Methods in molecular biology (Clifton, N.J.) , 2011 | Pubmed ID: 21913121
A gene expression phenotype in lymphocytes from Friedreich ataxia patients.
Annals of neurology Nov, 2011 | Pubmed ID: 22162061
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