Joel Gottesfeld

Promoter scanning for transcription inhibition with DNA-binding polyamides.

Cyclin L is an RS domain protein involved in pre-mRNA splicing.

Blocking transcription through a nucleosome with synthetic DNA ligands.

Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands.

RNA as a transcriptional activator.

Accessibility of nuclear chromatin by DNA binding polyamides.

Molecular recognition of the nucleosomal "supergroove".

Regulation of gene expression with pyrrole-imidazole polyamides.

Arresting cancer proliferation by small-molecule gene regulation.

Nucleosomes in solution exist as a mixture of twist-defect states.

Role of DNA sequence in the binding specificity of synthetic basic-helix-loop-helix domains.

Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides.

Induced fit and "lock and key" recognition of 5S RNA by zinc fingers of transcription factor IIIA.

Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin.

DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia.

A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate.

Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates.

Small molecules affecting transcription in Friedreich ataxia.

Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model.

Targeting specific gene by alkylating pyrrole-imidazole polyamides.

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.

Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.

Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.

Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing.

Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes.

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.

Chemical biology meets biological chemistry minireview series.

Development of histone deacetylase inhibitors as therapeutics for neurological disease.

Friedreich's ataxia induced pluripotent stem cells model intergenerational GAAâ‹…TTC triplet repeat instability.

Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model.

Introduction to the thematic minireview series on epigenetics.

Evaluation of histone deacetylase inhibitors as therapeutics for neurodegenerative diseases.

A gene expression phenotype in lymphocytes from Friedreich ataxia patients.