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Department of Biochemistry and Molecular Biology
Mauricio J. Reginato has not added Biography.
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ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells.
Journal of cell science Apr, 2010 | Pubmed ID: 20332114
Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis.
Molecular biology of the cell Nov, 2010 | Pubmed ID: 20861305
Surviving without oxygen: hypoxia regulation of mammary morphogenesis and anoikis.
Cell cycle (Georgetown, Tex.) Jul, 2011 | Pubmed ID: 21670595
Constitutive K-RasG12D activation of ERK2 specifically regulates 3D invasion of human pancreatic cancer cells via MMP-1.
Molecular cancer research : MCR Feb, 2012 | Pubmed ID: 22160930
Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis.
The Journal of biological chemistry Mar, 2012 | Pubmed ID: 22275356
ERK2-regulated TIMP1 induces hyperproliferation of K-Ras(G12D)-transformed pancreatic ductal cells.
Neoplasia (New York, N.Y.) Apr, 2013 | Pubmed ID: 23555182
The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance.
The Journal of biological chemistry May, 2013 | Pubmed ID: 23585570
Activated ERBB2/HER2 licenses sensitivity to apoptosis upon endoplasmic reticulum stress through a PERK-dependent pathway.
Cancer research Mar, 2014 | Pubmed ID: 24453000
Sticking to sugars at the metastatic site: sialyltransferase ST6GalNAc2 acts as a breast cancer metastasis suppressor.
Cancer discovery Mar, 2014 | Pubmed ID: 24596201
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.
Molecular cell Jun, 2014 | Pubmed ID: 24857547
Cancer metabolism: cross talk between signaling and O-GlcNAcylation.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 25030920
EMT Transition Alters Interstitial Fluid Flow-Induced Signaling in ERBB2-Positive Breast Cancer Cells.
Molecular cancer research : MCR Apr, 2015 | Pubmed ID: 25566992
Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2.
Oncotarget Feb, 2015 | Pubmed ID: 25596742
mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.
Molecular cancer research : MCR May, 2015 | Pubmed ID: 25636967
Emerging microtubule targets in glioma therapy.
Seminars in pediatric neurology Mar, 2015 | Pubmed ID: 25976261
Progress toward overcoming hypoxia-induced resistance to solid tumor therapy.
Cancer management and research , 2015 | Pubmed ID: 26316817
O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling.
Journal of molecular biology 08, 2016 | Pubmed ID: 27343361
O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.
Oncogene 01, 2017 | Pubmed ID: 27345396
Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis.
JCI insight Nov, 2016 | Pubmed ID: 27882343
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.
Oncogene 02, 2018 | Pubmed ID: 29059153
O-GlcNAcylation: key regulator of glycolytic pathways.
Journal of bioenergetics and biomembranes 06, 2018 | Pubmed ID: 29344764
Breast Cancer Brain Metastasis Response to Radiation After Microbubble Oxygen Delivery in a Murine Model.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Dec, 2019 | Pubmed ID: 31124171
Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer.
BMC biology 07, 2019 | Pubmed ID: 31272438
O-GlcNAc Transferase Regulates Cancer Stem-like Potential of Breast Cancer Cells.
Molecular cancer research : MCR 04, 2020 | Pubmed ID: 31974291
Drexel University College of Medicine
Thomas Jefferson University
Lorela Ciraku1,
Rebecca A. Moeller1,
Emily M. Esquea1,
Wiktoria A. Gocal1,
Edward J. Hartsough2,4,
Nicole L. Simone3,4,
Joshua G. Jackson2,
Mauricio J. Reginato1,4
1Department of Biochemistry and Molecular Biology, Drexel University College of Medicine,
2Department of Pharmacology and Physiology, Drexel University College of Medicine,
3Department of Radiation Oncology, Thomas Jefferson University,
4Sidney Kimmel Cancer Center, Thomas Jefferson University
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