Department of Chemical Biology
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DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes.
Nature communications Jun, 2014 | Pubmed ID: 24968874
Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.
Nature structural & molecular biology Sep, 2014 | Pubmed ID: 25108355
Myeloid disease: Another action of a thalidomide derivative.
Nature Jul, 2015 | Pubmed ID: 26131932
Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex.
Molecular and cellular biology Oct, 2015 | Pubmed ID: 26217014
CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription.
Transcription , 2015 | Pubmed ID: 26399478
Correction for Cao et al., Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex.
Molecular and cellular biology Dec, 2015 | Pubmed ID: 26518638
Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.
International journal of oncology Jan, 2016 | Pubmed ID: 26718641
Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors.
ACS chemical biology 05, 2016 | Pubmed ID: 26863403
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.
Nature communications Mar, 2016 | Pubmed ID: 26988023
Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.
Molecular cell Mar, 2016 | Pubmed ID: 26990986
Discovery of the target for immunomodulatory drugs (IMiDs).
[Rinsho ketsueki] The Japanese journal of clinical hematology 05, 2016 | Pubmed ID: 27263779
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Nature 07, 2016 | Pubmed ID: 27338790
Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.
International journal of hematology Sep, 2016 | Pubmed ID: 27460676
Cystathionine β-synthase and PGRMC1 as CO sensors.
Free radical biology & medicine 10, 2016 | Pubmed ID: 27565814
SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads regardless of their sizes and shapes.
Biotechnology reports (Amsterdam, Netherlands) Mar, 2015 | Pubmed ID: 28435806
The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.
Marine drugs Aug, 2017 | Pubmed ID: 28783126
Recent topics in IMiDs and cereblon.
[Rinsho ketsueki] The Japanese journal of clinical hematology , 2017 | Pubmed ID: 28978850
Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis.
International journal of hematology Jan, 2018 | Pubmed ID: 28986762
Effect of ruxolitinib therapy on the quality-of-life of Japanese patients with myelofibrosis.
Current medical research and opinion 03, 2018 | Pubmed ID: 29224367
Structural basis of thalidomide enantiomer binding to cereblon.
Scientific reports 01, 2018 | Pubmed ID: 29358579
Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma.
Blood 06, 2018 | Pubmed ID: 29685921
NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation.
The Journal of experimental medicine 08, 2018 | Pubmed ID: 29934320
Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.
Clinical chemistry 10, 2018 | Pubmed ID: 30021922
Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1.
Journal of clinical biochemistry and nutrition Jul, 2018 | Pubmed ID: 30087538
Application of high-performance magnetic nanobeads to biological sensing devices.
Analytical and bioanalytical chemistry Mar, 2019 | Pubmed ID: 30627798
Magnetically Promoted Rapid Immunofluorescence Staining for Frozen Tissue Sections.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 08, 2019 | Pubmed ID: 30958084
Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation.
iScience May, 2019 | Pubmed ID: 31055217
Arginine induces IGF-1 secretion from the endoplasmic reticulum.
Biochemical and biophysical research communications 07, 2019 | Pubmed ID: 31101333
Molecular mechanisms of cereblon-based drugs.
Pharmacology & therapeutics 10, 2019 | Pubmed ID: 31202702
Estradiol accelerates liver regeneration through estrogen receptor α.
Clinical and experimental gastroenterology , 2019 | Pubmed ID: 31413616
Successful Management of Acquired Factor V Inhibitor by Monitoring Factor V Activity, Antigen, and Inhibitor Values during Immunosuppressive Therapy.
Acta haematologica , 2020 | Pubmed ID: 31563916
p63 is a cereblon substrate involved in thalidomide teratogenicity.
Nature chemical biology 11, 2019 | Pubmed ID: 31591562
[Cereblon as a primary target of IMiDs].
[Rinsho ketsueki] The Japanese journal of clinical hematology , 2019 | Pubmed ID: 31597822
Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons.
Nature communications 02, 2020 | Pubmed ID: 32081878
Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide.
Scientific reports 03, 2020 | Pubmed ID: 32132601
Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites.
NPJ science of food , 2020 | Pubmed ID: 32133417
Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug-induced thrombocytopenia.
Blood 06, 2020 | Pubmed ID: 32219443
Molecular Mechanisms of the Teratogenic Effects of Thalidomide.
Pharmaceuticals (Basel, Switzerland) May, 2020 | Pubmed ID: 32414180
UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner.
Biochemical and biophysical research communications 06, 2020 | Pubmed ID: 32423812
Induction of adaptive immune responses against antigens incorporated within the capsid of simian virus 40.
The Journal of general virology 08, 2020 | Pubmed ID: 32501197
Molecular mechanisms of thalidomide and its derivatives.
Proceedings of the Japan Academy. Series B, Physical and biological sciences , 2020 | Pubmed ID: 32522938
Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway.
Proceedings of the National Academy of Sciences of the United States of America 09, 2020 | Pubmed ID: 32848052
-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer.
Cancers Aug, 2020 | Pubmed ID: 32878320
L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells.
Communications biology 09, 2020 | Pubmed ID: 32901087
ARID2 is a pomalidomide-dependent CRL4 substrate in multiple myeloma cells.
Nature chemical biology 11, 2020 | Pubmed ID: 32958952
Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection.
PLoS biology 09, 2020 | Pubmed ID: 32991574
Do not curse the darkness of the spinal cord, light TDP-43.
Neural regeneration research May, 2021 | Pubmed ID: 33229745
Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells.
Cellular signalling 06, 2021 | Pubmed ID: 33592249
Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS.
Cellular and molecular life sciences : CMLS May, 2021 | Pubmed ID: 33709256
Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma.
Journal of experimental & clinical cancer research : CR Mar, 2021 | Pubmed ID: 33757580
Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 33777938
Illuminating ALS Motor Neurons With Optogenetics in Zebrafish.
Frontiers in cell and developmental biology , 2021 | Pubmed ID: 33816488
Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses due to IMiD-induced PD-L1 Upregulation on Myeloma Cells.
Molecular cancer therapeutics 07, 2021 | Pubmed ID: 33879556
BRCA1 degradation in response to mitochondrial damage in breast cancer cells.
Scientific reports 04, 2021 | Pubmed ID: 33888730
Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology.
Cell chemical biology 07, 2021 | Pubmed ID: 34033753
Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1.
Cancers Jun, 2021 | Pubmed ID: 34209885
PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.
Communications biology 11, 2021 | Pubmed ID: 34764413
Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology.
Cancers Jan, 2022 | Pubmed ID: 35053527
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