Hiroshi Handa

DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes.

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.

Myeloid disease: Another action of a thalidomide derivative.

Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex.

CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription.

Correction for Cao et al., Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Nonoverlapping Functions of Rtf1 and the Paf1 Complex.

Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.

Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors.

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.

Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon.

Discovery of the target for immunomodulatory drugs (IMiDs).

A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.

Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs.

Cystathionine β-synthase and PGRMC1 as CO sensors.

SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads regardless of their sizes and shapes.

The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.

Recent topics in IMiDs and cereblon.

Evaluation of the dose and efficacy of ruxolitinib in Japanese patients with myelofibrosis.

Effect of ruxolitinib therapy on the quality-of-life of Japanese patients with myelofibrosis.

Structural basis of thalidomide enantiomer binding to cereblon.

Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma.

NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation.

Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.

Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1.

Application of high-performance magnetic nanobeads to biological sensing devices.

Magnetically Promoted Rapid Immunofluorescence Staining for Frozen Tissue Sections.

Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation.

Arginine induces IGF-1 secretion from the endoplasmic reticulum.

Molecular mechanisms of cereblon-based drugs.

Estradiol accelerates liver regeneration through estrogen receptor α.

Successful Management of Acquired Factor V Inhibitor by Monitoring Factor V Activity, Antigen, and Inhibitor Values during Immunosuppressive Therapy.

p63 is a cereblon substrate involved in thalidomide teratogenicity.

[Cereblon as a primary target of IMiDs].

Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons.

Genome-wide screening reveals a role for subcellular localization of CRBN in the anti-myeloma activity of pomalidomide.

Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites.

Aromatase is a novel neosubstrate of cereblon responsible for immunomodulatory drug-induced thrombocytopenia.

Molecular Mechanisms of the Teratogenic Effects of Thalidomide.

UGGT1 retains proinsulin in the endoplasmic reticulum in an arginine dependent manner.

Induction of adaptive immune responses against antigens incorporated within the capsid of simian virus 40.

Molecular mechanisms of thalidomide and its derivatives.

Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway.

-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer.

L-Arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells.

ARID2 is a pomalidomide-dependent CRL4 substrate in multiple myeloma cells.

Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection.

Do not curse the darkness of the spinal cord, light TDP-43.

Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells.

Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS.

Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma.

Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.

Illuminating ALS Motor Neurons With Optogenetics in Zebrafish.

Durvalumab Combined with Immunomodulatory Drugs (IMiD) Overcomes Suppression of Antitumor Responses due to IMiD-induced PD-L1 Upregulation on Myeloma Cells.

BRCA1 degradation in response to mitochondrial damage in breast cancer cells.

Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology.

Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1.

PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates.

Application of Magnetic Nanoparticles for Rapid Detection and In Situ Diagnosis in Clinical Oncology.