normothermic-negative-pressure-ventilation-ex-situ-lung-perfusion

Normothermic Negative Pressure Ventilation <em>Ex Situ</em> Lung Perfusion: Evaluation of Lung Function and Metabolism

Lung transplantation (LTx) remains the standard of care for end-stage lung disease. A shortage of suitable donor organs and concerns over donor organ ...

left-lung-orthotopic-transplantation-juvenile-porcine-model-for

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Lung transplantation is the gold-standard treatment for end-stage lung disease, with over 4,600 lung transplantations performed worldwide annually. ...

University of Alberta

Mazankowski Alberta Heart Institute

Aortico-left ventricular tunnel is a rare congenital anomaly requiring surgical repair early in childhood. After corrective surgery, such patients are at risk of developing aortic insufficiency and aortic root dilatation. Herein, we describe a valve-sparing aortic root replacement 3 decades after the repair of aortico-left ventricular tunnel.

Valve-Sparing Aortic Root Replacement 3 Decades After Repair of Aortico-Left Ventricular Tunnel.

Lung transplantation (LTx) is the gold standard treatment for end-stage lung disease; however, waitlist mortality remains high due to a shortage of suitable donor lungs. Organ quality can be compromised by lung ischemic reperfusion injury (LIRI). LIRI causes pulmonary endothelial inflammation and may lead to primary graft dysfunction (PGD). PGD is a significant cause of morbidity and mortality post-LTx. Research into preservation strategies that decrease the risk of LIRI and PGD is needed, and ex-situ lung perfusion (ESLP) is the foremost technological advancement in this field. This review addresses three major topics in the field of LTx: first, we review the clinical manifestation of LIRI post-LTx; second, we discuss the pathophysiology of LIRI that leads to pulmonary endothelial inflammation and PGD; and third, we present the role of ESLP as a therapeutic vehicle to mitigate this physiologic insult, increase the rates of donor organ utilization, and improve patient outcomes.

Keir A. Forgie

Division of Cardiac Surgery,
Department of Surgery,
Faculty of Medicine,
Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine

University of Alberta

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Keir A. Forgie

Division of Cardiac Surgery,Department of Surgery,Faculty of Medicine,Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine

University of Alberta

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Left Lung Orthotopic Transplantation in a Juvenile Porcine Model for ESLP

Division of Cardiac Surgery,
Department of Surgery,
Faculty of Medicine,
Division of Cardiac Surgery, Department of Surgery, Faculty of Medicine