Samar H. Ibrahim
Division of Gastroenterology & Hepatology,
Division of Pediatric Gastroenterology
Mayo Clinic
Dr. Ibrahim is the Principal Investigator of the NIH-funded lipotoxicity and liver inflammation laboratory at Mayo Clinic. She studies the mechanism of liver injury and inflammation in nonalcoholic steatohepatitis (NASH), with the goal to identify novel biomarkers and mechanism-based therapeutic targets. Her recently published work identified the vascular adhesion molecule 1 (VCAM1) as a potential novel therapeutic target in NASH. Dr. Ibrahim and her research team have examined the role of extracellular vesicles as biomarkers, as well as mediators of intercellular communication in NASH pathobiology. They recently defined the role of integrin β1-enriched extracellular vesicles in NASH. She is a member of the executive committee of the center of Cell Signaling in Gastroenterology at Mayo Clinic, and the director the Pilot and Feasibility program at the Digestive Disease Center at Mayo Clinic and moderates the center weekly Scientific Seminar Series. Dr. Ibrahim has served on NIDDK study sections, as well as a reviewer for international funding agencies. Dr. Ibrahim has mentored numerous medical students, residents, and postdoctoral fellows. She is an associate editor for “HEPATOLOGY” and a member of the basic science committee at the American Association for the study of Liver Diseases (AASLD) .
Incidence of gastrointestinal symptoms in children with autism: a population-based study.
Pediatrics Aug, 2009 | Pubmed ID: 19651585
Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis.
Journal of hepatology Apr, 2011 | Pubmed ID: 21147505
Current management of primary sclerosing cholangitis in pediatric patients.
Paediatric drugs Apr, 2011 | Pubmed ID: 21351808
Treatment of isolated gastric Crohn's disease with inhaled corticosteroids.
Case reports in gastroenterology Nov, 2008 | Pubmed ID: 21490870
Mechanisms of lipotoxicity in NAFLD and clinical implications.
Journal of pediatric gastroenterology and nutrition Aug, 2011 | Pubmed ID: 21629127
A 3-year-old with immunoglobulin G4-associated cholangitis.
Journal of pediatric gastroenterology and nutrition Jul, 2011 | Pubmed ID: 21694546
Who pulls the trigger: JNK activation in liver lipotoxicity?
Journal of hepatology Jan, 2012 | Pubmed ID: 21703172
A surgical model in male obese rats uncovers protective effects of bile acids post-bariatric surgery.
Endocrinology Jul, 2013 | Pubmed ID: 23592746
Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis.
PloS one , 2013 | Pubmed ID: 23894677
Multiple liver lesions in an immunosuppressed patient: is infection always the answer?
Case reports in gastroenterology , 2013 | Pubmed ID: 24019765
Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis.
Liver international : official journal of the International Association for the Study of the Liver Mar, 2014 | Pubmed ID: 24256559
Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes.
Hepatology (Baltimore, Md.) Mar, 2016 | Pubmed ID: 26406121
Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame.
Digestive diseases and sciences May, 2016 | Pubmed ID: 26626909
Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes.
Gastroenterology Apr, 2016 | Pubmed ID: 26764184
Omega-3 Fatty Acid-rich Parenteral Nutrition: Is It a Double-edged Sword?
Journal of pediatric gastroenterology and nutrition 05, 2016 | Pubmed ID: 27111227
CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis.
Scientific reports 06, 2016 | Pubmed ID: 27349927
Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1.
Science translational medicine Jul, 2016 | Pubmed ID: 27464750
Extracellular vesicles in liver pathobiology: Small particles with big impact.
Hepatology (Baltimore, Md.) 12, 2016 | Pubmed ID: 27628960
Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism During Hepatocyte Lipotoxicity.
Journal of cellular biochemistry 10, 2017 | Pubmed ID: 28262979
Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis.
JCI insight Aug, 2017 | Pubmed ID: 28768902
TRAIL Deletion Prevents Liver, but Not Adipose Tissue, Inflammation during Murine Diet-Induced Obesity.
Hepatology communications Sep, 2017 | Pubmed ID: 29124251
A Molecular Signature of Mouse NASH: A Step Closer to a Human Predictive Biomarker?
Cellular and molecular gastroenterology and hepatology , 2018 | Pubmed ID: 29276752
Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation.
Gut 05, 2018 | Pubmed ID: 29367207
Use of the CRISPR/Cas9-based epigenetic gene activation system In Vivo: A new potential therapeutic modality.
Hepatology (Baltimore, Md.) 09, 2018 | Pubmed ID: 29489018
Perinatal Nutritional Reprogramming of the Epigenome Promotes Subsequent Development of Nonalcoholic Steatohepatitis.
Hepatology communications Dec, 2018 | Pubmed ID: 30556038
Integrin β-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH.
Journal of hepatology 12, 2019 | Pubmed ID: 31433301
Liver Diseases in the Perinatal Period: Interactions Between Mother and Infant.
Hepatology (Baltimore, Md.) 04, 2020 | Pubmed ID: 31925801
Renal Function Parameters and Serum Sodium Enhance Prediction of Wait-List Outcomes in Pediatric Liver Transplantation.
Hepatology (Baltimore, Md.) 03, 2021 | Pubmed ID: 32485002
Nonalcoholic Steatohepatitis Promoting Kinases.
Seminars in liver disease 11, 2020 | Pubmed ID: 32526787
IRE1A Stimulates Hepatocyte-Derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis.
Gastroenterology 10, 2020 | Pubmed ID: 32574624
Impact of Acuity Circles on Outcomes for Pediatric Liver Transplant Candidates.
Transplantation 08, 2020 | Pubmed ID: 32732840
Emerging Roles of Liver Sinusoidal Endothelial Cells in Nonalcoholic Steatohepatitis.
Biology Nov, 2020 | Pubmed ID: 33198153
Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis.
The Journal of clinical investigation 03, 2021 | Pubmed ID: 33476308
Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications.
American journal of physiology. Gastrointestinal and liver physiology 07, 2021 | Pubmed ID: 34037463
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Diagnosis and Management of Pediatric Acute Liver Failure.
Journal of pediatric gastroenterology and nutrition Aug, 2021 | Pubmed ID: 34347674
Clinical Implications for Children Developing Direct Hyperbilirubinemia on Extracorporeal Membrane Oxygenation.
Journal of pediatric gastroenterology and nutrition Dec, 2021 | Pubmed ID: 34856562
SOBRE A JoVE
Copyright © 2024 MyJoVE Corporation. Todos os direitos reservados