Justin D. Lathia has not added Biography.
If you are Justin D. Lathia and would like to personalize this page please email our Author Liaison for assistance.
Targeting A20 decreases glioma stem cell survival and tumor growth.
PLoS biology Feb, 2010 | Pubmed ID: 20186265
c-Myc is required for maintenance of glioma cancer stem cells.
PloS one , 2008 | Pubmed ID: 19020659
Adhesion- and migration-related side effects of phosphothioated CpG oligodeoxynucleotides.
Cell adhesion & migration Jul-Sep, 2009 | Pubmed ID: 19458479
Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth.
Stem cells (Dayton, Ohio) Oct, 2009 | Pubmed ID: 19658188
Squelching glioblastoma stem cells by targeting REST for proteasomal degradation.
Trends in neurosciences Nov, 2009 | Pubmed ID: 19748686
Integrin alpha 6 regulates glioblastoma stem cells.
Cell stem cell May, 2010 | Pubmed ID: 20452317
Erythropoietin Receptor Signaling Through STAT3 Is Required For Glioma Stem Cell Maintenance.
Genes & cancer Jan, 2010 | Pubmed ID: 20657792
Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology?
Stem cell reviews Jun, 2011 | Pubmed ID: 20957452
Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells.
Glia Jan, 2011 | Pubmed ID: 21046557
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
Cancer cell Apr, 2011 | Pubmed ID: 21481791
Deadly teamwork: neural cancer stem cells and the tumor microenvironment.
Cell stem cell May, 2011 | Pubmed ID: 21549324
Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.
Cell Jul, 2011 | Pubmed ID: 21729780
Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells.
PloS one , 2011 | Pubmed ID: 21961046
Twisted tango: brain tumor neurovascular interactions.
Nature neuroscience Oct, 2011 | Pubmed ID: 22030548
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth.
The Journal of experimental medicine Mar, 2012 | Pubmed ID: 22393126
Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma.
Cancer research Mar, 2012 | Pubmed ID: 22396498
Holding on to stemness.
Nature cell biology May, 2012 | Pubmed ID: 22552145
Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity.
Genes & development Jun, 2012 | Pubmed ID: 22661233
Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair.
Trends in neurosciences Oct, 2012 | Pubmed ID: 22784557
The malignant social network: cell-cell adhesion and communication in cancer stem cells.
Cell adhesion & migration Jul-Aug, 2012 | Pubmed ID: 22796941
Laminin alpha 2 enables glioblastoma stem cell growth.
Annals of neurology Nov, 2012 | Pubmed ID: 23280793
Multiplex flow cytometry barcoding and antibody arrays identify surface antigen profiles of primary and metastatic colon cancer cell lines.
PloS one , 2013 | Pubmed ID: 23308131
Growth factor receptors define cancer hierarchies.
Cancer cell Feb, 2013 | Pubmed ID: 23410969
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth.
Cell Mar, 2013 | Pubmed ID: 23540695
Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy.
PloS one , 2013 | Pubmed ID: 23936469
Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma.
PloS one , 2013 | Pubmed ID: 23951053
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake.
Nature neuroscience Oct, 2013 | Pubmed ID: 23995067
Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells.
Endocrine-related cancer Dec, 2013 | Pubmed ID: 24025407
The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina.
Experimental eye research Feb, 2014 | Pubmed ID: 24246263
miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2014 | Pubmed ID: 24368849
High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor.
Cell reports Jan, 2014 | Pubmed ID: 24373972
Decoding the cancer stem cell hypothesis in glioblastoma.
CNS oncology Jul, 2013 | Pubmed ID: 24379973
EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.
Oncogene Jan, 2015 | Pubmed ID: 24488013
Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression.
Stem cells (Dayton, Ohio) Jul, 2014 | Pubmed ID: 24737733
Modeling mayhem: predicting invasion and proliferation kinetics in IDH1 mutant glioblastoma with mathematical models.
Neuro-oncology Jun, 2014 | Pubmed ID: 24739516
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation.
Nature cell biology May, 2014 | Pubmed ID: 24747440
Role of cysteine-rich 61 protein (CCN1) in macrophage-mediated oncolytic herpes simplex virus clearance.
Molecular therapy : the journal of the American Society of Gene Therapy Sep, 2014 | Pubmed ID: 24895995
Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells.
Glia Oct, 2014 | Pubmed ID: 24909307
Cancer stem cells: moving past the controversy.
CNS oncology Nov, 2013 | Pubmed ID: 25054813
Development of a Sox2 reporter system modeling cellular heterogeneity in glioma.
Neuro-oncology Mar, 2015 | Pubmed ID: 25416826
High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues.
Nature photonics , 2014 | Pubmed ID: 25621002
Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple-Negative Breast Cancer.
Stem cells (Dayton, Ohio) Jul, 2015 | Pubmed ID: 25827713
Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.
Science signaling May, 2015 | Pubmed ID: 25943352
Differential connexin function enhances self-renewal in glioblastoma.
Cell reports May, 2015 | Pubmed ID: 25959821
Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration.
Oncotarget May, 2015 | Pubmed ID: 25960544
Cancer stem cells in glioblastoma.
Genes & development Jun, 2015 | Pubmed ID: 26109046
Insulin-mediated signaling promotes proliferation and survival of glioblastoma through Akt activation.
Neuro-oncology Jan, 2016 | Pubmed ID: 26136493
The intersection of cancer, cancer stem cells, and the immune system: therapeutic opportunities.
Neuro-oncology Feb, 2016 | Pubmed ID: 26264894
Coordination of self-renewal in glioblastoma by integration of adhesion and microRNA signaling.
Neuro-oncology 05, 2016 | Pubmed ID: 26374689
Cx25 contributes to leukemia cell communication and chemosensitivity.
Oncotarget Oct, 2015 | Pubmed ID: 26375552
Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells.
Cancer cell Oct, 2015 | Pubmed ID: 26461092
Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models.
Cancer research 04, 2016 | Pubmed ID: 26921329
Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury.
Journal of neurotrauma 01, 2017 | Pubmed ID: 26976047
Cisplatin induces stemness in ovarian cancer.
Oncotarget May, 2016 | Pubmed ID: 27105520
Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion.
Stem cells (Dayton, Ohio) 08, 2016 | Pubmed ID: 27145382
Taking a Toll on Self-Renewal: TLR-Mediated Innate Immune Signaling in Stem Cells.
Trends in neurosciences 07, 2016 | Pubmed ID: 27155992
Reporter Systems to Study Cancer Stem Cells.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27221339
Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells.
Oncotarget May, 2016 | Pubmed ID: 27270311
Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation.
Cell reports 07, 2016 | Pubmed ID: 27396333
Migrating glioma cells express stem cell markers and give rise to new tumors upon xenografting.
Journal of neuro-oncology 10, 2016 | Pubmed ID: 27510953
Adhering towards tumorigenicity: altered adhesion mechanisms in glioblastoma cancer stem cells.
CNS oncology Oct, 2016 | Pubmed ID: 27616054
Tetraspanin CD9 stabilizes gp130 by preventing its ubiquitin-dependent lysosomal degradation to promote STAT3 activation in glioma stem cells.
Cell death and differentiation 01, 2017 | Pubmed ID: 27740621
Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression.
Cell stem cell 04, 2017 | Pubmed ID: 28089910
Isolation, Characterization, and Expansion of Cancer Stem Cells.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28229412
Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 04, 2017 | Pubmed ID: 28374184
Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma.
Oncotarget May, 2017 | Pubmed ID: 28410193
An update on minding the gap in cancer.
Biochimica et biophysica acta Jan, 2018 | Pubmed ID: 28655619
Overview of Cancer Stem Cells and Stemness for Community Oncologists.
Targeted oncology 08, 2017 | Pubmed ID: 28664387
RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis.
Stem cell reports 08, 2017 | Pubmed ID: 28689994
STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance.
Endocrine-related cancer 08, 2017 | Pubmed ID: 28729467
Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value.
PloS one , 2017 | Pubmed ID: 28837569
CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors.
The Journal of experimental medicine Sep, 2017 | Pubmed ID: 28838952
Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2017 | Pubmed ID: 28912141
New Advances and Challenges of Targeting Cancer Stem Cells.
Cancer research 10, 2017 | Pubmed ID: 28928129
A 4-miRNA signature to predict survival in glioblastomas.
PloS one , 2017 | Pubmed ID: 29136645
Inhibition of Farnesyltransferase Potentiates NOTCH-Targeted Therapy against Glioblastoma Stem Cells.
Stem cell reports 12, 2017 | Pubmed ID: 29198824
Revealing the glioma cancer stem cell interactome, one niche at a time.
The Journal of pathology Mar, 2018 | Pubmed ID: 29282720
Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.
Nature communications 02, 2018 | Pubmed ID: 29422613
Females have the survival advantage in glioblastoma.
Neuro-oncology 03, 2018 | Pubmed ID: 29474647
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Transcriptional control of O -methylguanine DNA methyltransferase expression and temozolomide resistance in glioblastoma' on page 780.
Journal of neurochemistry 03, 2018 | Pubmed ID: 29644711
Therapeutic Injury and Tumor Regrowth: Tumor Resection and Radiation Establish the Recurrent Glioblastoma Microenvironment.
EBioMedicine 05, 2018 | Pubmed ID: 29699876
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
Scientific reports May, 2018 | Pubmed ID: 29743610
An anatomic transcriptional atlas of human glioblastoma.
Science (New York, N.Y.) 05, 2018 | Pubmed ID: 29748285
Five-Part Pentameric Nanocomplex Shows Improved Efficacy of Doxorubicin in CD44+ Cancer Cells.
ACS omega Nov, 2017 | Pubmed ID: 30023561
Comparing and Contrasting the Effects of Condensin II Subunit dCAP-D3 Overexpression and Depletion .
Genetics 10, 2018 | Pubmed ID: 30068527
Sex-specific gene and pathway modeling of inherited glioma risk.
Neuro-oncology 01, 2019 | Pubmed ID: 30124908
Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models.
Cancer discovery 01, 2019 | Pubmed ID: 30361447
Global immune fingerprinting in glioblastoma patient peripheral blood reveals immune-suppression signatures associated with prognosis.
JCI insight 11, 2018 | Pubmed ID: 30385717
Targeting Cancer Stemness in the Clinic: From Hype to Hope.
Cell stem cell 01, 2019 | Pubmed ID: 30595497
Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data.
Science translational medicine 01, 2019 | Pubmed ID: 30602536
High-Throughput Automated Single-Cell Imaging Analysis Reveals Dynamics of Glioblastoma Stem Cell Population During State Transition.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 03, 2019 | Pubmed ID: 30729665
Drak, Drak, Goose: A New Signaling Axis in Glioblastoma.
Cancer research 03, 2019 | Pubmed ID: 30877099
Development of a Cx46 Targeting Strategy for Cancer Stem Cells.
Cell reports 04, 2019 | Pubmed ID: 31018124
IL-11 drives postsurgical hepatocellular carcinoma recurrence.
EBioMedicine 09, 2019 | Pubmed ID: 31402232
ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.
Cancer discovery 11, 2019 | Pubmed ID: 31434712
The dystroglycan receptor maintains glioma stem cells in the vascular niche.
Acta neuropathologica 12, 2019 | Pubmed ID: 31463571
Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells.
JCI insight 11, 2019 | Pubmed ID: 31600167
Thy-1 predicts poor prognosis and is associated with self-renewal in ovarian cancer.
Journal of ovarian research Nov, 2019 | Pubmed ID: 31735168
Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer.
Scientific reports 11, 2019 | Pubmed ID: 31776402
ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells.
Molecular & cellular oncology , 2020 | Pubmed ID: 31993498
Optimising gene editing for cancer therapy.
Nature cell biology 03, 2020 | Pubmed ID: 32086445
Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells.
Cell death & disease 02, 2020 | Pubmed ID: 32102991
FGF2: a novel druggable target for glioblastoma?
Expert opinion on therapeutic targets 04, 2020 | Pubmed ID: 32174197
MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma.
Molecular metabolism 04, 2020 | Pubmed ID: 32180553
Myeloid-Derived Suppressor Cell Subsets Drive Glioblastoma Growth in a Sex-Specific Manner.
Cancer discovery 08, 2020 | Pubmed ID: 32300059
Sex Differences in Cancer Incidence and Survival: A Pan-Cancer Analysis.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 07, 2020 | Pubmed ID: 32349967
Release the ballast: Glioblastoma rises above radiation therapy by exporting miR-603 in extracellular vesicles to become treatment-resistant.
EBioMedicine 06, 2020 | Pubmed ID: 32502962
JAM-A functions as a female microglial tumor suppressor in glioblastoma.
Neuro-oncology 11, 2020 | Pubmed ID: 32592484
Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression.
Frontiers in immunology , 2020 | Pubmed ID: 32625208
Sexually dimorphic impact of the iron-regulating gene, , on survival in glioblastoma.
Neuro-oncology advances Jan-Dec, 2020 | Pubmed ID: 32642673
Junctional Adhesion Molecules in Cancer: A Paradigm for the Diverse Functions of Cell-Cell Interactions in Tumor Progression.
Cancer research 11, 2020 | Pubmed ID: 32816855
SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells.
EMBO molecular medicine 12, 2020 | Pubmed ID: 33124191
Hepatobiliary malignancies have distinct peripheral myeloid-derived suppressor cell signatures and tumor myeloid cell profiles.
Scientific reports 11, 2020 | Pubmed ID: 33139767
The evolution of the cancer stem cell state in glioblastoma: emerging insights into the next generation of functional interactions.
Neuro-oncology 02, 2021 | Pubmed ID: 33173943
High-Dimensional Analysis of Circulating and Tissue-Derived Myeloid-Derived Suppressor Cells from Patients with Glioblastoma.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33237547
Connexins in Cancer: Jekyll or Hyde?
Biomolecules 12, 2020 | Pubmed ID: 33321749
Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells.
JCI insight 02, 2021 | Pubmed ID: 33351787
Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma.
Journal of medicinal chemistry 02, 2021 | Pubmed ID: 33523674
Preclinical Modeling of Surgery and Steroid Therapy for Glioblastoma Reveals Changes in Immunophenotype that are Associated with Tumor Growth and Outcome.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2021 | Pubmed ID: 33542075
Comprehensive characterization of protein-protein interactions perturbed by disease mutations.
Nature genetics 03, 2021 | Pubmed ID: 33558758
Cancer cell heterogeneity & plasticity in glioblastoma and brain tumors.
Seminars in cancer biology Feb, 2021 | Pubmed ID: 33640445
A circuitous route to GBM stem cell signalling.
Nature cell biology 03, 2021 | Pubmed ID: 33664497
Go, cancer stem cell, go! CSCs overcome myelin inhibition to move within white matter pathways.
Brain : a journal of neurology 03, 2021 | Pubmed ID: 33693693
Fountain of chaos: cerebrospinal fluid enhancement of cancer stem cells in glioblastoma.
Neuro-oncology 04, 2021 | Pubmed ID: 33749775
Sex Differences in Glioblastoma Immunotherapy Response.
Neuromolecular medicine Apr, 2021 | Pubmed ID: 33864598
Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches.
Acta neuropathologica communications 05, 2021 | Pubmed ID: 34059134
Cancer stem cell-immune cell crosstalk in tumour progression.
Nature reviews. Cancer 08, 2021 | Pubmed ID: 34103704
Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma.
The Journal of clinical investigation Jul, 2021 | Pubmed ID: 34255747
Neutralizing shapeshifting pericytes enhances glioblastoma therapeutic efficacy.
Cell research Oct, 2021 | Pubmed ID: 34267351
Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19.
Signal transduction and targeted therapy 07, 2021 | Pubmed ID: 34330889
Bazedoxifene inhibits sustained STAT3 activation and increases survival in GBM.
Translational oncology Nov, 2021 | Pubmed ID: 34365219
Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas.
Neuro-oncology Aug, 2021 | Pubmed ID: 34387331
The Translocator Protein () Genetic Polymorphism A147T Is Associated with Worse Survival in Male Glioblastoma Patients.
Cancers Sep, 2021 | Pubmed ID: 34572751
Hydrogen sulfide operates as a glioblastoma suppressor and is lost under high fat diet.
Molecular & cellular oncology , 2021 | Pubmed ID: 34616877
All damage is not created equal: unraveling the complexity of sex chromosomes and hormones in the DNA damage response.
Endocrinology Oct, 2021 | Pubmed ID: 34618897
Dionysios C. Watson1,2,3,
Sadie Johnson1,
Akeem Santos1,4,
Mei Yin5,
Defne Bayik1,
Justin D. Lathia1,3,
Mohammed Dwidar1,3,4
1Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic,
2, University Hospitals Cleveland Medical Center,
3, Case Western Reserve University,
4Center for Microbiome & Human Health, Cleveland Clinic,
5Electron Microscopy Core, Lerner Research Institute, Cleveland Clinic
SOBRE A JoVE
Copyright © 2024 MyJoVE Corporation. Todos os direitos reservados