Gottfried Schatz Research Center for Cell Signaling,
Metabolism and Aging,
Molecular Biology and Biochemistry,
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry
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Enhanced inter-compartmental Ca flux modulates mitochondrial metabolism and apoptotic threshold during aging.
Redox biology 01, 2019 | Pubmed ID: 30458321
Hop/Sti1 phosphorylation inhibits its co-chaperone function.
EMBO reports Feb, 2015 | Pubmed ID: 25504578
A compact native 24-residue supersecondary structure derived from the villin headpiece subdomain.
Biophysical journal Feb, 2015 | Pubmed ID: 25650934
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.
Nature communications Feb, 2015 | Pubmed ID: 25695750
Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM.
Biochimica et biophysica acta Oct, 2015 | Pubmed ID: 25748881
Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules.
Nature communications Apr, 2015 | Pubmed ID: 25851214
Type-II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction.
Molecular microbiology Oct, 2015 | Pubmed ID: 26172206
The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin.
The Journal of biological chemistry Nov, 2015 | Pubmed ID: 26459561
Optimization of lipid production with a genome-scale model of Yarrowia lipolytica.
BMC systems biology Oct, 2015 | Pubmed ID: 26503450
The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.
Scientific reports Nov, 2015 | Pubmed ID: 26593036
Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.
eLife Jan, 2016 | Pubmed ID: 26744780
Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.
Acta neuropathologica Apr, 2016 | Pubmed ID: 26895297
Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
Nature structural & molecular biology Apr, 2016 | Pubmed ID: 26974125
Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.
Diabetologia Aug, 2016 | Pubmed ID: 27153842
Prediction of Protein Structure Using Surface Accessibility Data.
Angewandte Chemie (International ed. in English) 09, 2016 | Pubmed ID: 27560616
PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.
Nature communications Sep, 2016 | Pubmed ID: 27642082
Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.
Acta crystallographica. Section F, Structural biology communications 10, 2016 | Pubmed ID: 27710939
Importance of cycle timing for the function of the molecular chaperone Hsp90.
Nature structural & molecular biology Nov, 2016 | Pubmed ID: 27723736
Increasing the Chemical-Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent.
Angewandte Chemie (International ed. in English) 11, 2016 | Pubmed ID: 27763708
Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).
The FEBS journal 04, 2017 | Pubmed ID: 28236663
Long-range allosteric signaling in red light-regulated diguanylyl cyclases.
Science advances Mar, 2017 | Pubmed ID: 28275738
Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.
Nature communications 03, 2017 | Pubmed ID: 28281558
The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.
Scientific reports 03, 2017 | Pubmed ID: 28287098
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.
Cell 03, 2017 | Pubmed ID: 28340339
Transient helicity in intrinsically disordered Axin-1 studied by NMR spectroscopy and molecular dynamics simulations.
PloS one , 2017 | Pubmed ID: 28355271
Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity.
The Journal of allergy and clinical immunology 10, 2017 | Pubmed ID: 28532654
RNA structure refinement using NMR solvent accessibility data.
Scientific reports 07, 2017 | Pubmed ID: 28710477
Characterization of Protein-Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements.
Journal of the American Chemical Society 09, 2017 | Pubmed ID: 28780861
Patchy proteins form a perfect lens.
Science (New York, N.Y.) 08, 2017 | Pubmed ID: 28798115
Integrative metabolomics as emerging tool to study autophagy regulation.
Microbial cell (Graz, Austria) Jul, 2017 | Pubmed ID: 28845422
Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo.
Nature communications 11, 2017 | Pubmed ID: 29127288
A switch point in the molecular chaperone Hsp90 responding to client interaction.
Nature communications 04, 2018 | Pubmed ID: 29662162
Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.
Cell 04, 2018 | Pubmed ID: 29677514
Regulation of cellular senescence via the FOXO4-p53 axis.
FEBS letters 06, 2018 | Pubmed ID: 29683489
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.
Journal of hepatology 08, 2018 | Pubmed ID: 29709678
Acetate-free, citrate-acidified bicarbonate dialysis improves serum calcification propensity-a preliminary study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 11, 2018 | Pubmed ID: 29860419
The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.
Science advances 06, 2018 | Pubmed ID: 29963623
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.
Cell metabolism 11, 2018 | Pubmed ID: 30122555
Oxidative stress-induced structural changes in the microtubule-associated flavoenzyme Irc15p from Saccharomyces cerevisiae.
Protein science : a publication of the Protein Society 01, 2019 | Pubmed ID: 30267443
NMR spectroscopy enables simultaneous quantification of carbohydrates for diagnosis of intestinal and gastric permeability.
Scientific reports 10, 2018 | Pubmed ID: 30279548
Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes.
Frontiers in physiology , 2018 | Pubmed ID: 30487758
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.
Biochimica et biophysica acta. Molecular cell research 03, 2019 | Pubmed ID: 30595160
A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers.
PloS one , 2019 | Pubmed ID: 30707717
Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2019 | Pubmed ID: 30790505
pH-Lemon, a Fluorescent Protein-Based pH Reporter for Acidic Compartments.
ACS sensors 04, 2019 | Pubmed ID: 30864782
The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.
Molecular cell 04, 2019 | Pubmed ID: 30876805
Impaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal Disease.
Circulation research Apr, 2019 | Pubmed ID: 30929571
Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex.
Journal of molecular biology 06, 2019 | Pubmed ID: 31034892
Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients.
Scientific reports 05, 2019 | Pubmed ID: 31043697
Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice.
Cardiovascular research 02, 2020 | Pubmed ID: 31166588
Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.
The Journal of biological chemistry 08, 2019 | Pubmed ID: 31209110
Endothelial lipase increases antioxidative capacity of high-density lipoprotein.
Biochimica et biophysica acta. Molecular and cell biology of lipids 10, 2019 | Pubmed ID: 31220617
NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins.
Journal of biomolecular NMR Jul, 2019 | Pubmed ID: 31297688
Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.
Cell metabolism 09, 2019 | Pubmed ID: 31471173
Presenilin-1 Established ER-Ca Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2019 | Pubmed ID: 31529929
Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16.
Redox biology 01, 2020 | Pubmed ID: 31539802
A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro.
FEBS letters 02, 2020 | Pubmed ID: 31605637
Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine.
Nucleic acids research 01, 2020 | Pubmed ID: 31754719
Probing Surfaces in Dynamic Protein Interactions.
Journal of molecular biology 04, 2020 | Pubmed ID: 32135192
Nonclassical nuclear localization signals mediate nuclear import of CIRBP.
Proceedings of the National Academy of Sciences of the United States of America 04, 2020 | Pubmed ID: 32234784
Transgene integration causes RARB downregulation in homozygous Tg4-42 mice.
Scientific reports 04, 2020 | Pubmed ID: 32286473
Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner.
mSystems Jun, 2020 | Pubmed ID: 32518196
Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
The Journal of biological chemistry 10, 2020 | Pubmed ID: 32546481
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans.
Science translational medicine 10, 2020 | Pubmed ID: 33115954
β-catenin regulates FOXP2 transcriptional activity via multiple binding sites.
The FEBS journal 05, 2021 | Pubmed ID: 33284517
Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.
Cell reports 12, 2020 | Pubmed ID: 33357437
Imbalances in the eye lens proteome are linked to cataract formation.
Nature structural & molecular biology 02, 2021 | Pubmed ID: 33432246
Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL.
International journal of molecular sciences Jan, 2021 | Pubmed ID: 33450841
Tissue-Specific Landscape of Metabolic Dysregulation during Ageing.
Biomolecules 02, 2021 | Pubmed ID: 33562384
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy Feb, 2021 | Pubmed ID: 33634751
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease.
Journal of Alzheimer's disease : JAD , 2021 | Pubmed ID: 33646155
Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia.
International journal of molecular sciences Feb, 2021 | Pubmed ID: 33671212
Dietary spermidine improves cognitive function.
Cell reports 04, 2021 | Pubmed ID: 33852843
NLRP3 as a sensor of metabolism gone awry.
Current opinion in biotechnology 04, 2021 | Pubmed ID: 33862489
Potassium ions promote hexokinase-II dependent glycolysis.
iScience Apr, 2021 | Pubmed ID: 33870140
Growing Human Hepatocellular Tumors Undergo a Global Metabolic Reprogramming.
Cancers Apr, 2021 | Pubmed ID: 33924061
ATP regulates RNA-driven cold inducible RNA binding protein phase separation.
Protein science : a publication of the Protein Society 07, 2021 | Pubmed ID: 33991007
Wide-Range, Rapid, and Specific Identification of Pathogenic Bacteria by Surface-Enhanced Raman Spectroscopy.
ACS sensors 08, 2021 | Pubmed ID: 34282892
Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function.
Cell reports Jul, 2021 | Pubmed ID: 34320339
Metabolic profiling links cardiovascular risk and vascular end organ damage.
Atherosclerosis 08, 2021 | Pubmed ID: 34344526
Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR.
The Journal of biological chemistry 10, 2021 | Pubmed ID: 34487759
Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans.
Microbiome 09, 2021 | Pubmed ID: 34560884
Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients.
Nutrients Sep, 2021 | Pubmed ID: 34578983
Intracellular drug binding affinities by NMR.
Acta crystallographica. Section D, Structural biology Oct, 2021 | Pubmed ID: 34605425
Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.
Frontiers in molecular biosciences , 2021 | Pubmed ID: 34738012
XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
Science immunology 11, 2021 | Pubmed ID: 34739338
p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR.
International journal of molecular sciences Oct, 2021 | Pubmed ID: 34768862
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