Tobias Madl

Enhanced inter-compartmental Ca flux modulates mitochondrial metabolism and apoptotic threshold during aging.

Hop/Sti1 phosphorylation inhibits its co-chaperone function.

A compact native 24-residue supersecondary structure derived from the villin headpiece subdomain.

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM.

Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules.

Type-II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction.

The Solution Structure of the Lantibiotic Immunity Protein NisI and Its Interactions with Nisin.

Optimization of lipid production with a genome-scale model of Yarrowia lipolytica.

The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.

Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha.

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.

Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.

Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.

Prediction of Protein Structure Using Surface Accessibility Data.

PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca(2+) uptake in immortalized cells.

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.

Importance of cycle timing for the function of the molecular chaperone Hsp90.

Increasing the Chemical-Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent.

Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).

Long-range allosteric signaling in red light-regulated diguanylyl cyclases.

Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.

The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.

Transient helicity in intrinsically disordered Axin-1 studied by NMR spectroscopy and molecular dynamics simulations.

Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity.

RNA structure refinement using NMR solvent accessibility data.

Characterization of Protein-Protein Interfaces in Large Complexes by Solid-State NMR Solvent Paramagnetic Relaxation Enhancements.

Patchy proteins form a perfect lens.

Integrative metabolomics as emerging tool to study autophagy regulation.

Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo.

A switch point in the molecular chaperone Hsp90 responding to client interaction.

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation.

Regulation of cellular senescence via the FOXO4-p53 axis.

Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis.

Acetate-free, citrate-acidified bicarbonate dialysis improves serum calcification propensity-a preliminary study.

The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.

Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.

Oxidative stress-induced structural changes in the microtubule-associated flavoenzyme Irc15p from Saccharomyces cerevisiae.

NMR spectroscopy enables simultaneous quantification of carbohydrates for diagnosis of intestinal and gastric permeability.

Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes.

N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.

A single alcohol binge impacts on neutrophil function without changes in gut barrier function and gut microbiome composition in healthy volunteers.

Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells.

pH-Lemon, a Fluorescent Protein-Based pH Reporter for Acidic Compartments.

The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.

Impaired Retinal Vessel Dilation Predicts Mortality in End-Stage Renal Disease.

Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered Protein Complex.

Serum Concentrations of Citrate, Tyrosine, 2- and 3- Hydroxybutyrate are Associated with Increased 3-Month Mortality in Acute Heart Failure Patients.

Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice.

Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.

Endothelial lipase increases antioxidative capacity of high-density lipoprotein.

NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins.

Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans.

Presenilin-1 Established ER-Ca Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells upon Elevated Glucose.

Cysteine oxidation triggers amyloid fibril formation of the tumor suppressor p16.

A small molecule chaperone rescues the stability and activity of a cancer-associated variant of NAD(P)H:quinone oxidoreductase 1 in vitro.

Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine.

Probing Surfaces in Dynamic Protein Interactions.

Nonclassical nuclear localization signals mediate nuclear import of CIRBP.

Transgene integration causes RARB downregulation in homozygous Tg4-42 mice.

Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and -Independent Manner.

Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.

Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans.

β-catenin regulates FOXP2 transcriptional activity via multiple binding sites.

Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions.

Imbalances in the eye lens proteome are linked to cataract formation.

Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL.

Tissue-Specific Landscape of Metabolic Dysregulation during Ageing.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer's Disease.

Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia.

Dietary spermidine improves cognitive function.

NLRP3 as a sensor of metabolism gone awry.

Potassium ions promote hexokinase-II dependent glycolysis.

Growing Human Hepatocellular Tumors Undergo a Global Metabolic Reprogramming.

ATP regulates RNA-driven cold inducible RNA binding protein phase separation.

Wide-Range, Rapid, and Specific Identification of Pathogenic Bacteria by Surface-Enhanced Raman Spectroscopy.

Multiple regulatory intrinsically disordered motifs control FOXO4 transcription factor binding and function.

Metabolic profiling links cardiovascular risk and vascular end organ damage.

Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR.

Reduced B12 uptake and increased gastrointestinal formate are associated with archaeome-mediated breath methane emission in humans.

Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients.

Intracellular drug binding affinities by NMR.

Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation.

XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.

p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR.