Department of Biochemistry and Cell Biology
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Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.
Molecular biology of the cell Jun, 2012 | Pubmed ID: 22535524
Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition.
Structure (London, England : 1993) Jun, 2013 | Pubmed ID: 23665168
Dueling kinases regulate cell size at division through the SAD kinase Cdr2.
Current biology : CB Feb, 2014 | Pubmed ID: 24508166
Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion.
Molecular biology of the cell Jan, 2015 | Pubmed ID: 25411340
SPECHT - single-stage phosphopeptide enrichment and stable-isotope chemical tagging: quantitative phosphoproteomics of insulin action in muscle.
Journal of proteomics Jan, 2015 | Pubmed ID: 25463755
Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Molecular & cellular proteomics : MCP May, 2015 | Pubmed ID: 25720772
Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells.
Science signaling Oct, 2015 | Pubmed ID: 26462736
Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells.
Stem cells (Dayton, Ohio) 05, 2016 | Pubmed ID: 26756672
Identification of Candidate Cyclin-dependent kinase 1 (Cdk1) Substrates in Mitosis by Quantitative Phosphoproteomics.
Molecular & cellular proteomics : MCP 07, 2016 | Pubmed ID: 27134283
HOPS catalyzes the interdependent assembly of each vacuolar SNARE into a SNARE complex.
Molecular biology of the cell Apr, 2017 | Pubmed ID: 28148647
A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase.
The Journal of cell biology 08, 2017 | Pubmed ID: 28630147
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.
Proceedings of the National Academy of Sciences of the United States of America 08, 2017 | Pubmed ID: 28807998
Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
eLife 11, 2017 | Pubmed ID: 29154753
PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.
Journal of the American Chemical Society 12, 2017 | Pubmed ID: 29156132
Identification of Candidate Casein Kinase 2 Substrates in Mitosis by Quantitative Phosphoproteomics.
Frontiers in cell and developmental biology , 2017 | Pubmed ID: 29214152
Mechanisms Connecting the Conserved Protein Kinases Ssp1, Kin1, and Pom1 in Fission Yeast Cell Polarity and Division.
Current biology : CB 01, 2018 | Pubmed ID: 29249658
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine 03, 2018 | Pubmed ID: 29436393
Coordination of Protein Kinase and Phosphoprotein Phosphatase Activities in Mitosis.
Frontiers in cell and developmental biology , 2018 | Pubmed ID: 29623276
Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.
Science signaling 05, 2018 | Pubmed ID: 29764989
Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.
Science signaling 05, 2018 | Pubmed ID: 29764992
Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.
Scientific reports Jun, 2018 | Pubmed ID: 29934597
A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.
Molecular & cellular proteomics : MCP 12, 2018 | Pubmed ID: 30228194
Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.
Science advances 11, 2018 | Pubmed ID: 30443599
The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora.
Molecular cell 05, 2019 | Pubmed ID: 30954403
A complex containing lysine-acetylated actin inhibits the formin INF2.
Nature cell biology 05, 2019 | Pubmed ID: 30962575
R-DeeP: Proteome-wide and Quantitative Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation.
Molecular cell 07, 2019 | Pubmed ID: 31076284
Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer.
Molecular oncology 08, 2019 | Pubmed ID: 31180176
A Transcriptionally Definable Subgroup of Triple-Negative Breast and Ovarian Cancer Samples Shows Sensitivity to HSP90 Inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research 01, 2020 | Pubmed ID: 31558472
A Consensus Binding Motif for the PP4 Protein Phosphatase.
Molecular cell 12, 2019 | Pubmed ID: 31585692
Leveraging New Definitions of the LxVP SLiM To Discover Novel Calcineurin Regulators and Substrates.
ACS chemical biology 12, 2019 | Pubmed ID: 31633908
A mechanism for how Cdr1/Nim1 kinase promotes mitotic entry by inhibiting Wee1.
Molecular biology of the cell 12, 2019 | Pubmed ID: 31644361
Identification, quantification and bioinformatic analysis of RNA-dependent proteins by RNase treatment and density gradient ultracentrifugation using R-DeeP.
Nature protocols 04, 2020 | Pubmed ID: 32094787
A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment.
eLife 03, 2020 | Pubmed ID: 32195664
Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits.
The EMBO journal 07, 2020 | Pubmed ID: 32400009
Fission yeast Pak1 phosphorylates anillin-like Mid1 for spatial control of cytokinesis.
The Journal of cell biology 08, 2020 | Pubmed ID: 32421151
Quantitative kinase and phosphatase profiling reveal that CDK1 phosphorylates PP2Ac to promote mitotic entry.
Science signaling 09, 2020 | Pubmed ID: 32900880
Effects of carboxyl-terminal methylation on holoenzyme function of the PP2A subfamily.
Biochemical Society transactions 10, 2020 | Pubmed ID: 33125487
Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.
The EMBO journal 12, 2020 | Pubmed ID: 33226137
A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth.
The Journal of biological chemistry Jan-Jun, 2021 | Pubmed ID: 33482199
Coupling of Cdc20 inhibition and activation by BubR1.
The Journal of cell biology 05, 2021 | Pubmed ID: 33819340
Use of Mitotic Protein Kinase Inhibitors and Phospho-Specific Antibodies to Monitor Protein Phosphorylation During the Cell Cycle.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 34085225
Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes.
eLife 08, 2021 | Pubmed ID: 34342579
Affinity-based profiling of endogenous phosphoprotein phosphatases by mass spectrometry.
Nature protocols 10, 2021 | Pubmed ID: 34518704
A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination.
Nature communications 09, 2021 | Pubmed ID: 34593815
Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation.
Scientific reports 11, 2021 | Pubmed ID: 34845248
The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway.
PLoS genetics 01, 2022 | Pubmed ID: 34982775
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Molecular biology of the cell Apr, 2022 | Pubmed ID: 35427150
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