Betty Tyler

The intracerebral administration of phenytoin using controlled-release polymers reduces experimental seizures in rats.

Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy.

Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor.

Prevention of experimental cerebral vasospasm by intracranial delivery of a nitric oxide donor from a controlled-release polymer: toxicity and efficacy studies in rabbits and rats.

Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies.

Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma.

Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo.

Section on tumors: Young Investigator Award: Local release of carboplatin via an Alzet mini-osmotic pump prolongs survival in a rat brainstem tumor model.

A novel rat model for the study of intraosseous metastatic spine cancer.

Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma.

Local delivery of doxorubicin for the treatment of malignant brain tumors in rats.

A novel intramedullary spinal cord tumor model: functional, radiological, and histopathological characterization.

Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis.

Coexpression of neuronatin splice forms promotes medulloblastoma growth.

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells.

Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.

A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats.

Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model.

FasL gene knock-down therapy enhances the antiglioma immune response.

Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas.

Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides.

Local delivery of rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats.

Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel.

Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.

The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas.

Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells.

Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging.

Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model.

Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model.

Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma.

Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models.

Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models.

Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres.

Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy.

Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model.

Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma.

Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.

Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy.

Miniaturized optical neuroimaging in unrestrained animals.

Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats.

MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.

Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis.

The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory.

Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies.

Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications.

Polylactic acid (PLA) controlled delivery carriers for biomedical applications.

Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.

Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM.

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.

Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model.

The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma.

HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.

Evaluation of an in vivo model for ventricular shunt infection: a pilot study using a novel antimicrobial-loaded polymer.

Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer.

A miniature multi-contrast microscope for functional imaging in freely behaving animals.

Evaluation of select biocompatible markers for labelling peripheral nerves on 11.7 T MRI.

The Use of Ribavirin as an Anticancer Therapeutic: Will It Go Viral?

Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.

Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor.

Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies.

Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration.

Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model.

Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma.

Captopril inhibits Matrix Metalloproteinase-2 and extends survival as a temozolomide adjuvant in an intracranial gliosarcoma model.

High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications.

Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma.

Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model.

Combined intracranial Acriflavine, temozolomide and radiation extends survival in a rat glioma model.

Automatic detection of cotton balls during brain surgery: Where deep learning meets ultrasound imaging to tackle foreign objects.

Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma.

Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology.

Metformin and Cancer, an Ambiguanidous Relationship.

Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches.

Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted Therapy.

Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier.

A Highly Translatable Dual-arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor-bearing Brain Tissues.

Dendrimer Technology in Glioma: Functional Design and Potential Applications.

Towards standardization of the parameters for opening the blood-brain barrier with focused ultrasound to treat glioblastoma multiforme: A systematic review of the devices, animal models, and therapeutic compounds used in rodent tumor models.

Impact of international research fellows in neurosurgery: results from a single academic center.

The Neurodevelopmental and Molecular Landscape of Medulloblastoma Subgroups: Current Targets and the Potential for Combined Therapies.

Preclinical Models and Technologies in Glioblastoma Research: Evolution, Current State, and Future Avenues.

Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke.

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment.

Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion.

CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy.