Department of Neurosurgery,
Neurosurgery
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The intracerebral administration of phenytoin using controlled-release polymers reduces experimental seizures in rats.
Epilepsy research Feb, 2002 | Pubmed ID: 11904233
Polymer delivery of camptothecin against 9L gliosarcoma: release, distribution, and efficacy.
Journal of neuro-oncology Feb, 2002 | Pubmed ID: 12061726
Hypertonic saline ameliorates cerebral edema associated with experimental brain tumor.
Journal of neurosurgical anesthesiology Jul, 2002 | Pubmed ID: 12172290
Prevention of experimental cerebral vasospasm by intracranial delivery of a nitric oxide donor from a controlled-release polymer: toxicity and efficacy studies in rabbits and rats.
Stroke; a journal of cerebral circulation Nov, 2002 | Pubmed ID: 12411661
Polilactofate microspheres for Paclitaxel delivery to central nervous system malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2003 | Pubmed ID: 12960135
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma.
Journal of neuro-oncology Sep, 2003 | Pubmed ID: 14558595
Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo.
Neurosurgery May, 2004 | Pubmed ID: 15113479
Section on tumors: Young Investigator Award: Local release of carboplatin via an Alzet mini-osmotic pump prolongs survival in a rat brainstem tumor model.
Clinical neurosurgery , 2004 | Pubmed ID: 15571163
A novel rat model for the study of intraosseous metastatic spine cancer.
Journal of neurosurgery. Spine Mar, 2005 | Pubmed ID: 15796355
Local delivery of interleukin-2 and adriamycin is synergistic in the treatment of experimental malignant glioma.
Journal of neuro-oncology Sep, 2005 | Pubmed ID: 16193383
Local delivery of doxorubicin for the treatment of malignant brain tumors in rats.
Anticancer research Nov-Dec, 2005 | Pubmed ID: 16312042
A novel intramedullary spinal cord tumor model: functional, radiological, and histopathological characterization.
Journal of neurosurgery. Spine Aug, 2005 | Pubmed ID: 16370303
Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasis.
Cancer research Sep, 2007 | Pubmed ID: 17804705
Coexpression of neuronatin splice forms promotes medulloblastoma growth.
Neuro-oncology Oct, 2008 | Pubmed ID: 18701710
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells.
Molecular cancer therapeutics Feb, 2009 | Pubmed ID: 19208828
Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
Journal of neuro-oncology Mar, 2010 | Pubmed ID: 19693439
A thermal gel depot for local delivery of paclitaxel to treat experimental brain tumors in rats.
Journal of neurosurgery Aug, 2010 | Pubmed ID: 20001591
Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model.
Neurosurgery Mar, 2010 | Pubmed ID: 20173548
FasL gene knock-down therapy enhances the antiglioma immune response.
Neuro-oncology May, 2010 | Pubmed ID: 20406899
Evaluation of retinoic acid therapy for OTX2-positive medulloblastomas.
Neuro-oncology Jul, 2010 | Pubmed ID: 20511190
Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides.
Nature medicine Jan, 2011 | Pubmed ID: 21170048
Local delivery of rapamycin: a toxicity and efficacy study in an experimental malignant glioma model in rats.
Neuro-oncology Jul, 2011 | Pubmed ID: 21727209
Delayed onset of paresis in rats with experimental intramedullary spinal cord gliosarcoma following intratumoral administration of the paclitaxel delivery system OncoGel.
Journal of neurosurgery. Spine Jan, 2012 | Pubmed ID: 22208429
Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.
Biomaterials Aug, 2012 | Pubmed ID: 22591609
The impact of bevacizumab on temozolomide concentrations in intracranial U87 gliomas.
Cancer chemotherapy and pharmacology Jul, 2012 | Pubmed ID: 22644796
Suppression of human glioma xenografts with second-generation IL13R-specific chimeric antigen receptor-modified T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2012 | Pubmed ID: 22966020
Growth properties of SF188/V+ human glioma in rats in vivo observed by magnetic resonance imaging.
Journal of neuro-oncology Dec, 2012 | Pubmed ID: 23011120
Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model.
Journal of neuro-oncology Feb, 2013 | Pubmed ID: 23224713
Microdialysis measurement of intratumoral temozolomide concentration after cediranib, a pan-VEGF receptor tyrosine kinase inhibitor, in a U87 glioma model.
Cancer chemotherapy and pharmacology Jul, 2013 | Pubmed ID: 23649683
Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma.
Journal of neurosurgery Oct, 2013 | Pubmed ID: 23909244
Combination of anti-VEGF therapy and temozolomide in two experimental human glioma models.
Journal of neuro-oncology Jan, 2014 | Pubmed ID: 24185441
Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models.
Journal of neurosurgery Apr, 2014 | Pubmed ID: 24484234
Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres.
Journal of neurosurgery May, 2014 | Pubmed ID: 24605841
Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy.
Stroke Apr, 2014 | Pubmed ID: 24627118
Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model.
PloS one , 2014 | Pubmed ID: 25013914
Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma.
Neuro-oncology Jan, 2015 | Pubmed ID: 25053853
Polymeric nanoparticles for nonviral gene therapy extend brain tumor survival in vivo.
ACS nano Feb, 2015 | Pubmed ID: 25643235
Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy.
Surgical neurology international , 2015 | Pubmed ID: 25722936
Miniaturized optical neuroimaging in unrestrained animals.
NeuroImage Jun, 2015 | Pubmed ID: 25791782
Uniform brain tumor distribution and tumor associated macrophage targeting of systemically administered dendrimers.
Biomaterials Jun, 2015 | Pubmed ID: 25818456
Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats.
Oncotarget Mar, 2015 | Pubmed ID: 25849940
MGMT inactivation and clinical response in newly diagnosed GBM patients treated with Gliadel.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Dec, 2015 | Pubmed ID: 26249244
Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis.
Journal of ophthalmology , 2015 | Pubmed ID: 26491546
The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory.
Academic medicine : journal of the Association of American Medical Colleges 06, 2016 | Pubmed ID: 26934692
Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies.
Journal of controlled release : official journal of the Controlled Release Society 10, 2016 | Pubmed ID: 27016141
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer , 2016 | Pubmed ID: 27190629
Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.
Biomaterials 09, 2016 | Pubmed ID: 27240162
Synthesis, characterization, and self-assembly with plasmid DNA of a quaternary ammonium derivative of pectic galactan and its fluorescent labeling for bioimaging applications.
Carbohydrate polymers Oct, 2016 | Pubmed ID: 27312642
Polylactic acid (PLA) controlled delivery carriers for biomedical applications.
Advanced drug delivery reviews 12, 2016 | Pubmed ID: 27426411
Erratum to: Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer , 2016 | Pubmed ID: 27822377
Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM.
Science translational medicine 12, 2016 | Pubmed ID: 28003545
Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats.
Journal of controlled release : official journal of the Controlled Release Society Oct, 2017 | Pubmed ID: 28279797
Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model.
Journal of neurosurgery. Spine Aug, 2017 | Pubmed ID: 28598292
The efficacy of lapatinib and nilotinib in combination with radiation therapy in a model of NF2 associated peripheral schwannoma.
Journal of neuro-oncology Oct, 2017 | Pubmed ID: 28735458
HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.
Scientific reports 11, 2017 | Pubmed ID: 29097800
Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma.
Oncotarget Apr, 2018 | Pubmed ID: 29755681
Evaluation of an in vivo model for ventricular shunt infection: a pilot study using a novel antimicrobial-loaded polymer.
Journal of neurosurgery 08, 2018 | Pubmed ID: 30074457
Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer.
Journal of controlled release : official journal of the Controlled Release Society 02, 2019 | Pubmed ID: 30605703
A miniature multi-contrast microscope for functional imaging in freely behaving animals.
Nature communications 01, 2019 | Pubmed ID: 30626878
Evaluation of select biocompatible markers for labelling peripheral nerves on 11.7 T MRI.
Journal of neuroscience methods 03, 2019 | Pubmed ID: 30630001
The Use of Ribavirin as an Anticancer Therapeutic: Will It Go Viral?
Molecular cancer therapeutics 07, 2019 | Pubmed ID: 31263027
Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies.
Nanomedicine : nanotechnology, biology, and medicine 01, 2020 | Pubmed ID: 31655205
Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor.
Scientific reports 11, 2019 | Pubmed ID: 31784666
Intraoperative Laser Speckle Contrast Imaging For Real-Time Visualization of Cerebral Blood Flow in Cerebrovascular Surgery: Results From Pre-Clinical Studies.
Scientific reports 05, 2020 | Pubmed ID: 32376983
Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration.
Bioengineering & translational medicine May, 2020 | Pubmed ID: 32440565
Evaluating the Effects of Cerebrospinal Fluid Protein Content on the Performance of Differential Pressure Valves and Antisiphon Devices Using a Novel Benchtop Shunting Model.
Neurosurgery 10, 2020 | Pubmed ID: 32521017
Repurposing the FDA-Approved Antiviral Drug Ribavirin as Targeted Therapy for Nasopharyngeal Carcinoma.
Molecular cancer therapeutics 09, 2020 | Pubmed ID: 32606016
Captopril inhibits Matrix Metalloproteinase-2 and extends survival as a temozolomide adjuvant in an intracranial gliosarcoma model.
Clinical neurology and neurosurgery 08, 2021 | Pubmed ID: 34198223
High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications.
Annals of biomedical engineering Sep, 2021 | Pubmed ID: 34374945
Synergy between glutamate modulation and anti-programmed cell death protein 1 immunotherapy for glioblastoma.
Journal of neurosurgery Feb, 2022 | Pubmed ID: 34388730
Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model.
PloS one , 2021 | Pubmed ID: 34731160
Combined intracranial Acriflavine, temozolomide and radiation extends survival in a rat glioma model.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V Jan, 2022 | Pubmed ID: 34968646
Automatic detection of cotton balls during brain surgery: Where deep learning meets ultrasound imaging to tackle foreign objects.
Proceedings of SPIE--the International Society for Optical Engineering Feb, 2021 | Pubmed ID: 35233128
Translational Regulation by hnRNP H/F Is Essential for the Proliferation and Survival of Glioblastoma.
Cancers Mar, 2022 | Pubmed ID: 35267591
Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology.
International journal of molecular sciences Apr, 2022 | Pubmed ID: 35456971
Metformin and Cancer, an Ambiguanidous Relationship.
Pharmaceuticals (Basel, Switzerland) May, 2022 | Pubmed ID: 35631452
Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches.
Polymers Jul, 2022 | Pubmed ID: 35890738
Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted Therapy.
Cancers Jul, 2022 | Pubmed ID: 35954407
Applications of Focused Ultrasound for the Treatment of Glioblastoma: A New Frontier.
Cancers Oct, 2022 | Pubmed ID: 36230843
A Highly Translatable Dual-arm Local Delivery Strategy To Achieve Widespread Therapeutic Coverage in Healthy and Tumor-bearing Brain Tissues.
Small (Weinheim an der Bergstrasse, Germany) Jan, 2023 | Pubmed ID: 36651002
Dendrimer Technology in Glioma: Functional Design and Potential Applications.
Cancers Feb, 2023 | Pubmed ID: 36831418
Towards standardization of the parameters for opening the blood-brain barrier with focused ultrasound to treat glioblastoma multiforme: A systematic review of the devices, animal models, and therapeutic compounds used in rodent tumor models.
Frontiers in oncology , 2022 | Pubmed ID: 36873300
Impact of international research fellows in neurosurgery: results from a single academic center.
Journal of neurosurgery Jan, 2022 | Pubmed ID: 34298505
The Neurodevelopmental and Molecular Landscape of Medulloblastoma Subgroups: Current Targets and the Potential for Combined Therapies.
Cancers Jul, 2023 | Pubmed ID: 37568705
Preclinical Models and Technologies in Glioblastoma Research: Evolution, Current State, and Future Avenues.
International journal of molecular sciences Nov, 2023 | Pubmed ID: 38003507
Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke.
Brain, behavior, and immunity Feb, 2024 | Pubmed ID: 38070624
GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment.
Experimental hematology & oncology Jan, 2024 | Pubmed ID: 38291540
Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion.
International journal of molecular sciences Feb, 2024 | Pubmed ID: 38473812
CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy.
Oncoimmunology , 2024 | Pubmed ID: 38590799
Safwan Alomari1,
Jayanidhi Kedda1,
Adarsha P. Malla2,3,
Victor Pacis1,
Pavlos Anastasiadis2,3,
Su Xu4,
Emylee McFarland2,3,
Lilia Sukhon1,
Bruno Gallo5,
Jordina Rincon-Torroella1,
Netanel Ben-Shalom1,
Heather M. Ames3,6,
Henry Brem1,7,
Graeme F. Woodworth2,3,
Betty Tyler1
1Department of Neurosurgery, Johns Hopkins University School of Medicine,
2Department of Neurosurgery, University of Maryland School of Medicine,
3Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine,
4Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine,
5, Pontifical Catholic University of Parana,
6Department of Pathology, University of Maryland School of Medicine,
7Departments of Ophthalmology, Oncology and Biomedical Engineering, Johns Hopkins University School of Medicine
Meghana Bhimreddy1,
Denis Routkevitch1,2,3,
Andrew M. Hersh1,
Ali Mohammadabadi1,3,
Arjun K. Menta1,
Kelly Jiang1,
Carly Weber-Levine1,
A. Daniel Davidar1,
Joshua Punnoose1,2,3,
Kelley M. Kempski Leadingham1,3,
Joshua C. Doloff2,
Betty Tyler1,
Nicholas Theodore1,3,
Amir Manbachi1,2,3,4,5,6
1Department of Neurosurgery, Johns Hopkins University School of Medicine,
2Department of Biomedical Engineering, Johns Hopkins University,
3HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine,
4Department of Electrical Engineering and Computer Science, Johns Hopkins University,
5Department of Mechanical Engineering, Johns Hopkins University,
6Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University
Ruixing Liang1,2,
Griffin Mess2,3,
Joshua Punnoose2,3,
Kelley M. Kempski Leadingham2,3,
Constantin Smit2,3,
Nitish Thakor1,4,
Christa W. Habela3,
Betty Tyler3,
Yousef Salimpour3,
Amir Manbachi1,2,3,4,5,6
1Electrical and Computer Engineering, Johns Hopkins University,
2HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine,
3Neurosurgery, Johns Hopkins University School of Medicine,
4Biomedical Engineering, Johns Hopkins University School of Medicine,
5Mechanical Engineering, Johns Hopkins University,
6Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine
Griffin Mess1,2,
Taylor Anderson1,2,
Shivani Kapoor3,
Rasika Thombre1,2,
Ruixing Liang4,
Emre Derin1,
Kelley M. Kempski-Leadingham1,
Santosh K. Yadav5,
Betty Tyler1,
Amir Manbachi1,2,4,6,7
1Department of Neurosurgery, Johns Hopkins University School of Medicine,
2Department of Biomedical Engineering, Johns Hopkins University,
3Krieger School of Arts and Sciences, Johns Hopkins University,
4Department of Electrical Engineering and Computer Science, Johns Hopkins University,
5Department of Radiology, Cancer Imaging Division, Johns Hopkins University School of Medicine,
6Department of Mechanical Engineering, Johns Hopkins University,
7Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine