preparation-an-awake-mouse-for-recording-neural-responses-injecting

Preparation of an Awake Mouse for Recording Neural Responses and Injecting Tracers

It is well known that anesthesia alters neural response properties in various regions of the brain.13.  In the auditory system, fundamental response ...

Johns Hopkins University

Garvan Institute of Medical Research

In mammals, the initial bridge between the physical world of sound and perception of that sound is established by neurons of the spiral ganglion. The cell bodies of these neurons give rise to peripheral processes that contact acoustic receptors in the organ of Corti, and the central processes collect together to form the auditory nerve that projects into the brain. In order to better understand hearing at this initial stage, we need to know the following about spiral ganglion neurons: (1) their cell biology including cytoplasmic, cytoskeletal, and membrane properties, (2) their peripheral and central connections including synaptic structure; (3) the nature of their neural signaling; and (4) their capacity for plasticity and rehabilitation. In this report, we will update the progress on these topics and indicate important issues still awaiting resolution.

The spiral ganglion: connecting the peripheral and central auditory systems.

Chez les mammif&egrave;res, le premier pont entre le monde physique du son et de la perception de ce bruit est &eacute;tabli par les neurones du ganglion spiral. Les corps cellulaires de ces neurones donnent lieu &agrave; des processus p&eacute;riph&eacute;riques entrer en contact avec les r&eacute;cepteurs acoustiques dans l&#39;organe de Corti, et les processus centrales rassembler pour former le nerf auditif qui se projette dans le cerveau. Afin de mieux comprendre l&#39;audience &agrave; ce stade initial, nous devons savoir ce qui suit sur les neurones du ganglion spiral: (1) leur cellule biologie y compris cytoplasmique, cytosquelette et propri&eacute;t&eacute;s de la membrane, (2) leurs connexions centrale et p&eacute;riph&eacute;riques, y compris la structure synaptique ; (3) la nature de leur signalisation neuronale ; et (4) leur capacit&eacute; de plasticit&eacute; et de r&eacute;habilitation. Dans le pr&eacute;sent rapport, nous mettre &agrave; jour les progr&egrave;s sur ces sujets et indiquer les questions importantes encore en attente de r&eacute;solution.

Le ganglion spiral : reliant les syst&egrave;mes auditifs centraux et p&eacute;riph&eacute;riques.

Nei mammiferi, il ponte tra il mondo fisico del suono e la percezione di quel suono iniziale &egrave; stabilito dai neuroni del ganglio spirale. I corpi cellulari di questi neuroni danno luogo a processi periferici che a contatto con i recettori acustici nell&#39;organo del Corti, e i processi centrali raccolgono insieme per formare il nervo uditivo che si proietta nel cervello. Al fine di comprendere meglio l&#39;audizione in questa fase iniziale, abbiamo bisogno di sapere quanto segue sui neuroni del ganglio spirale: (1) loro cellula biologia inclusi citoplasmatici, citoscheletriche e propriet&agrave; della membrana, (2) loro collegamenti centrali e periferici, inclusa la struttura sinaptica; (3) la natura della loro segnalazione neurale; e (4) la capacit&agrave; di plasticit&agrave; e riabilitazione. In questa relazione, aggiornare i progressi su questi argomenti e ci indicano importanti questioni ancora in attesa di risoluzione.

Michael A. Muniak

Department of Neuroscience

Johns Hopkins University

Preparation of an Awake Mouse for Recording Neural Responses and Injecting Tracers

Michael A. Muniak

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Neuroscience

Johns Hopkins University

Preparation of an Awake Mouse for Recording Neural Responses and Injecting Tracers

Department of Neuroscience