Melinda K. Duncan

Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes.

Truncated forms of Pax-6 disrupt lens morphology in transgenic mice.

Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression.

Prox1 is differentially localized during lens development.

General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice.

Collagen IV in the developing lens capsule.

A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens.

Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens.

Mafs, Prox1, and Pax6 can regulate chicken betaB1-crystallin gene expression.

Developmental expression of Pop1/Bves.

Chromosomal proteins HMGN3a and HMGN3b regulate the expression of glycine transporter 1.

OptiRNAi, an RNAi design tool.

Ectopic Pax6 expression disturbs lens fiber cell differentiation.

Palm is expressed in both developing and adult mouse lens and retina.

JAM-A expression during embryonic development.

Expression of tissue plasminogen activator during eye development.

Production of monoclonal antibodies against Prox1.

Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin.

Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens.

Deletion of JAM-A causes morphological defects in the corneal epithelium.

Subfertility in mice harboring a mutation in betaB2-crystallin.

Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.

Genetic and epigenetic mechanisms of gene regulation during lens development.

Attenuation of junctional adhesion molecule-A is a contributing factor for breast cancer cell invasion.

Dual roles for Prox1 in the regulation of the chicken betaB1-crystallin promoter.

Differential expression of the HMGN family of chromatin proteins during ocular development.

The lens capsule.

Contributions of mouse genetic background and age on anterior lens capsule thickness.

PCNA interacts with Prox1 and represses its transcriptional activity.

CD44 expression is developmentally regulated in the mouse lens and increases in the lens epithelium after injury.

Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract.

Characterizing molecular diffusion in the lens capsule.

Focus on molecules: Smad Interacting Protein 1 (Sip1, ZEB2, ZFHX1B).

Unfolded Protein Response (UPR) is activated during normal lens development.

Expression of βA3/A1-crystallin in the developing and adult rat eye.

Development. A new focus on RNA in the lens.

aV integrins and TGF-β-induced EMT: a circle of regulation.

The unfolded protein response is activated in connexin 50 mutant mouse lenses.

Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing.

Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.

The roles of αV integrins in lens EMT and posterior capsular opacification.

Lens extrusion from Laminin alpha 1 mutant zebrafish.

Beta-1 integrin is important for the structural maintenance and homeostasis of differentiating fiber cells.

The Zeb proteins δEF1 and Sip1 may have distinct functions in lens cells following cataract surgery.

Development of novel filtering criteria to analyze RNA-sequencing data obtained from the murine ocular lens during embryogenesis.

Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract.

Prox1 and fibroblast growth factor receptors form a novel regulatory loop controlling lens fiber differentiation and gene expression.

The molecular mechanisms underlying lens fiber elongation.

β1-integrin controls cell fate specification in early lens development.

Intravitreal methotrexate infusion for proliferative vitreoretinopathy.

β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis.

Spatiotemporal dynamics of canonical Wnt signaling during embryonic eye development and posterior capsular opacification (PCO).

Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery.

Cataract surgeon viewpoints on the need for novel preventative anti-inflammatory and anti-posterior capsular opacification therapies.

A new transgenic reporter line reveals Wnt-dependent Snai2 re-expression and cranial neural crest differentiation in Xenopus.

Fibronectin has multifunctional roles in posterior capsular opacification (PCO).

Morphometric analysis of the lens in human aniridia and mouse Small eye.

A simple method for quantitating confocal fluorescent images.

The aging mouse lens transcriptome.

The effect of sex on the mouse lens transcriptome.

αVβ8 integrin targeting to prevent posterior capsular opacification.

The Immediate Early Response of Lens Epithelial Cells to Lens Injury.

ATF4 May Be Essential for Adaption of the Ocular Lens to Its Avascular Environment.