Department of Molecular and Cell Biology,
California Institute for Quantitative Biology (QB3),
Howard Hughes Medical Institute
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Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly.
Nature Jun, 2005 | Pubmed ID: 15959508
The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.
Nature Mar, 2006 | Pubmed ID: 16415853
Structural mechanisms underlying nucleotide-dependent self-assembly of tubulin and its relatives.
Current opinion in structural biology Apr, 2006 | Pubmed ID: 16549346
My dream of a fantastic voyage to see the inner workings of a cell.
Molecular biology of the cell Nov, 2010 | Pubmed ID: 21079026
Multimodal microtubule binding by the Ndc80 kinetochore complex.
Nature structural & molecular biology Nov, 2012 | Pubmed ID: 23085714
Architecture of human translation initiation factor 3.
Structure (London, England : 1993) Jun, 2013 | Pubmed ID: 23623729
Architecture of the human XPC DNA repair and stem cell coactivator complex.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2015 | Pubmed ID: 26627236
Mutations in TUBB8 and Human Oocyte Meiotic Arrest.
The New England journal of medicine Jan, 2016 | Pubmed ID: 26789871
Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends.
Developmental cell Apr, 2016 | Pubmed ID: 27046833
Challenges and opportunities in the high-resolution cryo-EM visualization of microtubules and their binding partners.
Current opinion in structural biology Oct, 2017 | Pubmed ID: 28628789
Structures of human PRC2 with its cofactors AEBP2 and JARID2.
Science (New York, N.Y.) Feb, 2018 | Pubmed ID: 29348366
Cryo-EM structures of PRC2 simultaneously engaged with two functionally distinct nucleosomes.
Nature structural & molecular biology Feb, 2018 | Pubmed ID: 29379173
Cryo-EM structure of substrate-bound human telomerase holoenzyme.
Nature May, 2018 | Pubmed ID: 29695869
Near-atomic model of microtubule-tau interactions.
Science (New York, N.Y.) Jun, 2018 | Pubmed ID: 29748322
Separating the effects of nucleotide and EB binding on microtubule structure.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2018 | Pubmed ID: 29915050
Cryo-EM.
Current biology : CB Oct, 2018 | Pubmed ID: 30300591
Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science (New York, N.Y.) Dec, 2018 | Pubmed ID: 30442764
CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature Feb, 2019 | Pubmed ID: 30718774
Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors.
Nature Apr, 2019 | Pubmed ID: 30944483
Effects of α-tubulin acetylation on microtubule structure and stability.
Proceedings of the National Academy of Sciences of the United States of America May, 2019 | Pubmed ID: 31072936
Cryo-EM studies of NAIP-NLRC4 inflammasomes.
Methods in enzymology , 2019 | Pubmed ID: 31455527
High-resolution cryo-EM structures of TFIIH and their functional implications.
Current opinion in structural biology Dec, 2019 | Pubmed ID: 31600675
Recent insights into the structure of TFIID, its assembly, and its binding to core promoter.
Current opinion in structural biology Apr, 2020 | Pubmed ID: 31751889
The cryoelectron microscopy structure of the human CDK-activating kinase.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2020 | Pubmed ID: 32855301
The gammaherpesviral TATA-box-binding protein directly interacts with the CTD of host RNA Pol II to direct late gene transcription.
PLoS pathogens Sep, 2020 | Pubmed ID: 32886723
Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.
Science (New York, N.Y.) Dec, 2020 | Pubmed ID: 33273074
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
Science (New York, N.Y.) Jan, 2021 | Pubmed ID: 33479123
Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism.
eLife Apr, 2021 | Pubmed ID: 33821786
Structure of the human SAGA coactivator complex.
Nature structural & molecular biology Dec, 2021 | Pubmed ID: 34811519
The encapsulin from Thermotoga maritima is a flavoprotein with a symmetry matched ferritin-like cargo protein.
Scientific reports Nov, 2021 | Pubmed ID: 34815415
Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2022 | Pubmed ID: 34996871
The tubulin structure, a quarter of a century later.
Molecular biology of the cell Apr, 2023 | Pubmed ID: 36913319
A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery.
Cell Mar, 2023 | Pubmed ID: 36931247
Template and target site recognition by human LINE-1 in retrotransposition.
Nature Dec, 2023 | Pubmed ID: 38096901
Trinity Cookis1,
Paul Sauer2,3,
Simon Poepsel4,5,
Bong-Gyoon Han6,
Dominik A. Herbst1,2,6,
Robert Glaeser6,
Eva Nogales1,2,3,6
1Department of Molecular and Cell Biology, University of California, Berkeley,
2California Institute for Quantitative Biology (QB3), University of California, Berkeley,
3Howard Hughes Medical Institute, University of California, Berkeley,
4Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital, University of Cologne,
5Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne,
6Molecular Biophysics and Integrative Bio-Imaging Division, Lawrence Berkeley National Laboratory
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