an-ex-vivo-model-ovarian-cancer-peritoneal-metastasis-using-human

An <em>Ex Vivo</em> Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

Ovarian cancer is the deadliest gynecologic malignancy. The omentum plays a key role in providing a supportive microenvironment to metastatic ovarian ...

Wayne State University School of Medicine

Ovarian cancer recurs in most High Grade Serous Ovarian Cancer (HGSOC) patients, including initial responders, after standard of care. To improve patient survival, we need to identify and understand the factors contributing to early or late recurrence and therapeutically target these mechanisms. We hypothesized that in HGSOC, the response to chemotherapy is associated with a specific gene expression signature determined by the tumor microenvironment. In this study, we sought to determine the differences in gene expression and the tumor immune microenvironment between patients who show early recurrence (within 6 months) compared to those who show late recurrence following chemotherapy.

Hussein Chehade

C.S. Mott Center for Human Growth and Development,
Department of Obstetrics and Gynecology,
C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology

Wayne State University School of Medicine

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

Hussein Chehade

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}C.S. Mott Center for Human Growth and Development,Department of Obstetrics and Gynecology,C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology

Wayne State University School of Medicine

An Ex Vivo Model of Ovarian Cancer Peritoneal Metastasis Using Human Omentum

C.S. Mott Center for Human Growth and Development,
Department of Obstetrics and Gynecology,
C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology