Edward J. Kelly

A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes.

Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation.

Expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae reveals a functional role in aflatoxin B1 detoxification.

An RT-PCR-based strategy to estimate full-length CYP2D6 mRNA copy number.

The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice.

Characterization of the human MDR1 gene.

Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase.

Pharmacokinetics of metformin during pregnancy.

Pharmacogenetics of intravenous and oral busulfan in hematopoietic cell transplant recipients.

Development and characterization of transgenic mouse models for conditional gene knockout in the blood-brain and blood-CSF barriers.

Finding homes for orphan cytochrome P450s: CYP4V2 and CYP4F22 in disease states.

Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects.

Bioactivation of 4-Ipomeanol by a CYP4B enzyme in bovine lung and inhibition by HET0016.

Protein tyrosine nitration of mitochondrial carbamoyl phosphate synthetase 1 and its functional consequences.

CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.

Hepatic Cyp2d and Cyp26a1 mRNAs and Activities are Increased During Mouse Pregnancy.

Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol.

Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy.

Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system.

Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition.

Generation and characterization of a murine model of Bietti crystalline dystrophy.

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.

Identification of CYP3A7 for glyburide metabolism in human fetal livers.

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro.

Pharmacokinetics of metoprolol during pregnancy and lactation.

CYP2D6 Is Inducible by Endogenous and Exogenous Corticosteroids.

Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function.

Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity.

Development of a microphysiological model of human kidney proximal tubule function.

Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics.

Abundance of Drug Transporters in the Human Kidney Cortex as Quantified by Quantitative Targeted Proteomics.

Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity.

Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in .

Microphysiological Systems to Assess Nonclinical Toxicity.

Concise Review: Current and Emerging Biomarkers of Nephrotoxicity.

Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity.

Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system.

Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics.

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip.

A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation.

Reconstructing the Human Renal Vascular-Tubular Unit In Vitro.

Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.

Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System.

Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells.

A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.

Tissue Chips in Space-Challenges and Opportunities.

Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling.

Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism.

Microphysiological system modeling of ochratoxin A-associated nephrotoxicity.

Characterization of Differential Tissue Abundance of Major Non-CYP Enzymes in Human.

A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization-Dependent Cisplatin Toxicity.

Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.

Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: -oxidation as a potential augmenting pathway for inhibition.

Author Correction: Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.

Microphysiological systems in absorption, distribution, metabolism, and elimination sciences.

Kidney Organoid and Microphysiological Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing.

Gutsy science: In vitro systems of the human intestine to model oral drug disposition.

Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system.

Serum Protein Exposure Activates a Core Regulatory Program Driving Human Proximal Tubule Injury.

Kidney microphysiological models for nephrotoxicity assessment.

Molecular Mechanisms of Organic Anion Transporting Polypeptide-Mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier.

Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease.

Identification of prognostic biomarkers for antibiotic associated nephrotoxicity in cystic fibrosis.

Dysregulation of the mRNA Expression of Human Renal Drug Transporters by Proinflammatory Cytokines in Primary Human Proximal Tubular Epithelial Cells.

Development of a kidney microphysiological system hardware platform for microgravity studies.

Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system.

Human enteroid monolayers: A novel, functionally stable model for investigating oral drug disposition.