Thomas Friedrich

Pheochromocytoma and multifocal functioning paraganglioma in a 9-year-old boy with von Hippel-Lindau disease.

Complex cancer gene therapy in mice melanoma.

Proteorhodopsin is a light-driven proton pump with variable vectoriality.

Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?

Emergence of clonal cytogenetic abnormalities in Ph- cells in some CML patients in cytogenetic remission to imatinib but restoration of polyclonal hematopoiesis in the majority.

Cutaneous extramedullary hematopoiesis in idiopathic myelofibrosis.

Negative regulation of mitotic promoting factor by the checkpoint kinase chk1 in simian virus 40 lytic infection.

Reduced expression of p27kip1 and increased hepatocyte proliferation in p53-deficient mice.

A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.

Conformational dynamics of the Na+/K+-ATPase probed by voltage clamp fluorometry.

Determination of temperature elevation in tissue during the application of the harmonic scalpel.

Imatinib normalizes bone marrow vascularity in patients with chronic myeloid leukemia in first chronic phase.

Conformational dynamics of Na+/K+- and H+/K+-ATPase probed by voltage clamp fluorometry.

Two-electrode voltage-clamp analysis of Na,K-ATPase asparagine 776 mutants.

Electrophysiological analysis of the mutated Na,K-ATPase cation binding pocket.

Oral tumors and tumor-like lesions in infants and children.

Extraepitopic compensatory substitutions partially restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic-T-lymphocyte response.

Reversion of CTL escape-variant immunodeficiency viruses in vivo.

Consequences of cytotoxic T-lymphocyte escape: common escape mutations in simian immunodeficiency virus are poorly recognized in naive hosts.

Na,K-ATPase mutations in familial hemiplegic migraine lead to functional inactivation.

The beta subunit of the Na+/K+-ATPase follows the conformational state of the holoenzyme.

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

Rare missense variants in ATP1A2 in families with clustering of common forms of migraine.

The role of the SIV model in AIDS vaccine research.

Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells.

Crystal structure and enzyme kinetics of the (S)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain EbN1.

Structural determinants of M-type KCNQ (Kv7) K+ channel assembly.

The high-frequency major histocompatibility complex class I allele Mamu-B*17 is associated with control of simian immunodeficiency virus SIVmac239 replication.

Vaccine-induced cellular immune responses reduce plasma viral concentrations after repeated low-dose challenge with pathogenic simian immunodeficiency virus SIVmac239.

Repeated intravaginal inoculation with cell-associated simian immunodeficiency virus results in persistent infection of nonhuman primates.

Fluorometric measurements of intermolecular distances between the alpha- and beta-subunits of the Na+/K+-ATPase.

Simian immunodeficiency virus SIVmac239 infection of major histocompatibility complex-identical cynomolgus macaques from Mauritius.

Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication.

The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.

Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication.

Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.

Self-assembly of the isolated KCNQ2 subunit interaction domain.

Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives.

Functional cell-free synthesis of a seven helix membrane protein: in situ insertion of bacteriorhodopsin into liposomes.

The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.

Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation.

High-affinity cation binding to organic cation transporter 1 induces movement of helix 11 and blocks transport after mutations in a modeled interaction domain between two helices.

AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape.

Impaired routing of wild type FXYD2 after oligomerisation with FXYD2-G41R might explain the dominant nature of renal hypomagnesemia.

CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.

Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.

Structural arrangement and conformational dynamics of the gamma subunit of the Na+/K+-ATPase.

Delivery of the Cu-transporting ATPase ATP7B to the plasma membrane in Xenopus oocytes.

Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239.

Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick.

Characterization of Na,K-ATPase and H,K-ATPase enzymes with glycosylation-deficient beta-subunit variants by voltage-clamp fluorometry in Xenopus oocytes.

Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.

Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein.

Functionalized nanocompartments (synthosomes) with a reduction-triggered release system.

Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2.

Transport and sorting of the solanum tuberosum sucrose transporter SUT1 is affected by posttranslational modification.

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus.

Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.

Functional significance of E2 state stabilization by specific alpha/beta-subunit interactions of Na,K- and H,K-ATPase.

Synthesis and SAR of vinca alkaloid analogues.

Voltage clamp fluorometry: combining fluorescence and electrophysiological methods to examine the structure-function of the Na(+)/K(+)-ATPase.

Impaired plasma membrane targeting or protein stability by certain ATP1A2 mutations identified in sporadic or familial hemiplegic migraine.

Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus.

Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge.

Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection.

E2P state stabilization by the N-terminal tail of the H,K-ATPase beta-subunit is critical for efficient proton pumping under in vivo conditions.

Interactions of Na+,K+-ATPase and co-expressed delta-opioid receptor.

Voltage- and pH-dependent changes in vectoriality of photocurrents mediated by wild-type and mutant proteorhodopsins upon expression in Xenopus oocytes.

Infection with "escaped" virus variants impairs control of simian immunodeficiency virus SIVmac239 replication in Mamu-B*08-positive macaques.

Biaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part I.

Heterobiaryl purine derivatives as potent antiproliferative agents: inhibitors of cyclin dependent kinases. Part II.

Extralymphoid CD8+ T cells resident in tissue from simian immunodeficiency virus SIVmac239{Delta}nef-vaccinated macaques suppress SIVmac239 replication ex vivo.

Hyperpolarization-activated inward leakage currents caused by deletion or mutation of carboxy-terminal tyrosines of the Na+/K+-ATPase {alpha} subunit.

High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239.

MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques.

5-Functionalized indazoles as glucocorticoid receptor agonists.

Ex vivo analysis of SIV-infected cells by flow cytometry.

Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning.

Deceleration of the E1P-E2P transition and ion transport by mutation of potentially salt bridge-forming residues Lys-791 and Glu-820 in gastric H+/K+-ATPase.

Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virus.

Magnetic traveling-stripe forcing: Enhanced transport in the advent of the Rosensweig instability.

Novel, divergent simian hemorrhagic fever viruses in a wild Ugandan red colobus monkey discovered using direct pyrosequencing.

The TRIM5{alpha} genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge.

Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern.

Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques.

CD8+ T cell escape mutations in simian immunodeficiency virus SIVmac239 cause fitness defects in vivo, and many revert after transmission.

Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection.

Cross-reactive T cells are involved in rapid clearance of 2009 pandemic H1N1 influenza virus in nonhuman primates.

An outbreak of the 2009 influenza a (H1N1) virus in a children's hospital.

Plant stem cell niches.

Experimental analysis of sources of error in evolutionary studies based on Roche/454 pyrosequencing of viral genomes.

Control of gastric H,K-ATPase activity by cations, voltage and intracellular pH analyzed by voltage clamp fluorometry in Xenopus oocytes.

Coupling of Ci-VSP modules requires a combination of structure and electrostatics within the linker.

Mapping of RBE-weighted doses between HIMAC- and LEM-Based treatment planning systems for carbon ion therapy.

Spherical sample holders to improve the susceptibility measurement of superparamagnetic materials.

Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques.

Characterization in vitro and in vivo of pandemic (H1N1) 2009 influenza viruses isolated from patients.

Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype.

Modeling cell survival after photon irradiation based on double-strand break clustering in megabase pair chromatin loops.

Exceptional simian hemorrhagic fever virus diversity in a wild African primate community.

Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation-binding site.

Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation.

Immunogenicity of Seven New Recombinant Yellow Fever Viruses 17D Expressing Fragments of SIVmac239 Gag, Nef, and Vif in Indian Rhesus Macaques.

Particle species dependence of cell survival RBE: Evident and not negligible.

The linker pivot in Ci-VSP: the key to unlock catalysis.

Structural parameters controlling the fluorescence properties of phytochromes.

Screening of novel chemical compounds as possible inhibitors of carbonic anhydrase and photosynthetic activity of photosystem II.

eGFP-pHsens as a highly sensitive fluorophore for cellular pH determination by fluorescence lifetime imaging microscopy (FLIM).

Functional analysis of human Na(+)/K(+)-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes.

A missense variant of the ATP1A2 gene is associated with a novel phenotype of progressive sensorineural hearing loss associated with migraine.

Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research.

Photoacoustic imaging of fluorophores using pump-probe excitation.

The role of local and remote amino acid substitutions for optimizing fluorescence in bacteriophytochromes: A case study on iRFP.

ATP1A2 Mutations in Migraine: Seeing through the Facets of an Ion Pump onto the Neurobiology of Disease.

The purple Trp288Ala mutant of Synechocystis OCP persistently quenches phycobilisome fluorescence and tightly interacts with FRP.

Investigation of the NADH/NAD ratio in Ralstonia eutropha using the fluorescence reporter protein Peredox.

The Inner Workings of Proton Slippage through the Sodium Pump.

Fluorescent Labeling Preserving OCP Photoactivity Reveals Its Reorganization during the Photocycle.

Assembly of photoactive orange carotenoid protein from its domains unravels a carotenoid shuttle mechanism.

Interaction of the signaling state analog and the apoprotein form of the orange carotenoid protein with the fluorescence recovery protein.

Characterization of Frex as an NADH sensor for in vivo applications in the presence of NAD and at various pH values.

Fluorescent Labeling Preserving OCP Photoactivity Reveals Its Reorganization during the Photocycle.

Biophysical modeling of in vitro and in vivo processes underlying regulated photoprotective mechanism in cyanobacteria.

Common Structural Elements in the Chromophore Binding Pocket of the Pfr State of Bathy Phytochromes.

Deletion of the short N-terminal extension in OCP reveals the main site for FRP binding.

Retinoschisin is linked to retinal Na/K-ATPase signaling and localization.

The Unique Protein-to-Protein Carotenoid Transfer Mechanism.

Erratum to: Interaction of the signaling state analog and the apoprotein form of the orange carotenoid protein with the fluorescence recovery protein.

Disruption of Ankyrin B and Caveolin-1 Interaction Sites Alters Na,K-ATPase Membrane Diffusion.

Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity.

Functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP.

Photosynthesis supported by a chlorophyll f-dependent, entropy-driven uphill energy transfer in Halomicronema hongdechloris cells adapted to far-red light.

Molecular insights into antibiotic resistance - how a binding protein traps albicidin.

Doxorubicin induces caspase-mediated proteolysis of KV7.1.

Chromophore binding to two cysteines increases quantum yield of near-infrared fluorescent proteins.

Discriminating changes in intracellular NADH/NAD levels due to anoxicity and H supply in R. eutropha cells using the Frex fluorescence sensor.

Solution Structure and Conformational Flexibility in the Active State of the Orange Carotenoid Protein. Part II: Quasielastic Neutron Scattering.

Solution Structure and Conformational Flexibility in the Active State of the Orange Carotenoid Protein: Part I. Small-Angle Scattering.

Red, Orange, Green: Light- and Temperature-Dependent Color Tuning in a Cyanobacteriochrome.

Engineering the photoactive orange carotenoid protein with redox-controllable structural dynamics and photoprotective function.

The Lumi-R Intermediates of Prototypical Phytochromes.

NMR resonance assignment and backbone dynamics of a C-terminal domain homolog of orange carotenoid protein.

Soluble Cyanobacterial Carotenoprotein as a Robust Antioxidant Nanocarrier and Delivery Module.

Courses Based on iGEM/BIOMOD Competitions Are the Ideal Format for Research-Based Learning of Xenobiology.

Role of hydrogen bond alternation and charge transfer states in photoactivation of the Orange Carotenoid Protein.