Ralph Weissleder

Would near-infrared fluorescence signals propagate through large human organs for clinical studies?

Fast analytical approximation for arbitrary geometries in diffuse optical tomography.

A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages.

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.

Would near-infrared fluorescence signals propagate through large human organs for clinical studies? Errata.

Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.

Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy.

A highly selective fluorescent probe for thiol bioimaging.

Noninvasive imaging of apoptosis in cardiovascular disease.

Mast cells are an essential hematopoietic component for polyp development.

Utility of a new bolus-injectable nanoparticle for clinical cancer staging.

Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis.

Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions.

A secreted luciferase for ex vivo monitoring of in vivo processes.

Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.

Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury.

Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction.

A novel method of imaging calcium urolithiasis using fluorescence.

Pilot study evaluating use of lymphotrophic nanoparticle-enhanced magnetic resonance imaging for assessing lymph nodes in renal cell cancer.

Magnetic microparticle aggregation for viscosity determination by MR.

MR-optical imaging of cardiovascular molecular targets.

Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications.

Detection of early prostate cancer using a hepsin-targeted imaging agent.

Imaging in the era of molecular oncology.

Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma.

Sensitive NMR sensors detect antibodies to influenza.

Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model.

Perturbational profiling of nanomaterial biologic activity.

Multifunctional magnetic nanoparticles for targeted imaging and therapy.

Electrode chemistry yields a nanoparticle-based NMR sensor for calcium.

Chip-NMR biosensor for detection and molecular analysis of cells.

Slow self-activation enhances the potency of viridin prodrugs.

In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe.

Targeted imaging of myocardial damage.

Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy.

Near infrared fluorescence-based bacteriophage particles for ratiometric pH imaging.

Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging.

Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.

Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies.

Integrated nanosensors to determine levels and functional activity of human telomerase.

Simplified syntheses of complex multifunctional nanomaterials.

Real-time catheter molecular sensing of inflammation in proteolytically active atherosclerosis.

Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.

Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.

miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells.

Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide.

Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo.

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase.

Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation.

Tetrazine-based cycloadditions: application to pretargeted live cell imaging.

Monofunctional carbocyanine dyes for bio- and bioorthogonal conjugation.

A multifunctional single-attachment-point reagent for controlled protein biotinylation.

BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.

Design and demonstration of a small-animal up-conversion imager.

Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model.

18F labeled nanoparticles for in vivo PET-CT imaging.

Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.

Normalized Born ratio for fluorescence optical projection tomography.

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.

Mutant sodium channel for tumor therapy.

Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy.

Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.

Nanoparticle-target interactions parallel antibody-protein interactions.

Molecular imaging of innate immune cell function in transplant rejection.

Optical and multimodality molecular imaging: insights into atherosclerosis.

Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis.

Genetically engineered T cells to target EGFRvIII expressing glioblastoma.

Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle.

Implantable diagnostic device for cancer monitoring.

Multimodal nanoagents for the detection of intravascular thrombi.

Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors.

The antiproliferative cytostatic effects of a self-activating viridin prodrug.

A stabilized demethoxyviridin derivative inhibits PI3 kinase.

On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA).

Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.

Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system.

Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy.

Nuclear microscopy: a novel technique for quantitative imaging of gadolinium distribution within tissue sections.

Upconverting luminescent nanomaterials: application to in vivo bioimaging.

A DNA-binding Gd chelate for the detection of cell death by MRI.

Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors.

Synthesis and photophysical properties of sulfonamidophenyl porphyrins as models for activatable photosensitizers.

Rapid detection and profiling of cancer cells in fine-needle aspirates.

Identification of splenic reservoir monocytes and their deployment to inflammatory sites.

Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.

Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques.

High-yielding syntheses of hydrophilic conjugatable chlorins and bacteriochlorins.

Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition.

MRI of a novel murine working heart transplant model.

Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles.

Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study.

Enhancing navigation in biomedical databases by community voting and database-driven text classification.

Self-assembled multifunctional Fe/MgO nanospheres for magnetic resonance imaging and hyperthermia.

Oxazine conjugated nanoparticle detects in vivo hypochlorous acid and peroxynitrite generation.

Development of a Time Domain Fluorimeter for Fluorescent Lifetime Multiplexing Analysis.

18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis.

Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1.

Near-infrared fluorescence: application to in vivo molecular imaging.

A wortmannin-cetuximab as a double drug.

Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia.

Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure.

Notch signaling in cardiovascular disease and calcification.

Multicolor fluorescent intravital live microscopy (FILM) for surgical tumor resection in a mouse xenograft model.

Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.

Diffractionless beam in free space with adiabatic changing refractive index in a single mode tapered slab waveguide.

Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.

Early identification of aortic valve sclerosis using iron oxide enhanced MRI.

Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.

Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury.

High throughput transmission optical projection tomography using low cost graphics processing unit.

A novel molecule integrating therapeutic and diagnostic activities reveals multiple aspects of stem cell-based therapy.

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.

Imaging primary lung cancers in mice to study radiation biology.

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells.

Magnetic nanoparticle biosensors.

Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography.

Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.

Hybrid PET-optical imaging using targeted probes.

Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models.

The vascular biology of atherosclerosis and imaging targets.

Development of a bioorthogonal and highly efficient conjugation method for quantum dots using tetrazine-norbornene cycloaddition.

The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.

Molecular imaging of atherosclerosis: a progress report.

MRI with magnetic nanoparticles monitors downstream anti-angiogenic effects of mTOR inhibition.

Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice.

Near-infrared fluorescent probe for imaging of pancreatic beta cells.

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.

Intraoperative near-infrared fluorescent cholangiography (NIRFC) in mouse models of bile duct injury: reply.

Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection.

Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.

A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis.

Quantitating antibody uptake in vivo: conditional dependence on antigen expression levels.

Targeted nanoagents for the detection of cancers.

Quantitative nanostructure-activity relationship modeling.

Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications.

In vivo imaging in cancer.

Detection limits of intraoperative near infrared imaging for tumor resection.

Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction.

High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis.

Self-assembled magnetic filter for highly efficient immunomagnetic separation.

Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes.

Bioorthogonal small-molecule ligands for PARP1 imaging in living cells.

Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction.

WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud.

Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.

Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.

High-Yielding, Two-Step (18)F Labeling Strategy for (18)F-PARP1 Inhibitors.

Enhanced in vivo imaging of metabolically biotinylated cell surface reporters.

Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography.

Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method.

Micro-NMR for rapid molecular analysis of human tumor samples.

Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry.

High-yielding, two-step 18F labeling strategy for 18F-PARP1 inhibitors.

Molecular detection of biomarkers and cells using magnetic nanoparticles and diagnostic magnetic resonance.

Facile Synthesis of Monofunctional Pentamethine Carbocyanine Fluorophores.

In vivo tomographic imaging of red-shifted fluorescent proteins.

Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.

Miniature magnetic resonance system for point-of-care diagnostics.

Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.

Report of the National Heart, Lung, and Blood Institute working group on the translation of cardiovascular molecular imaging.

Indocyanine green enables near-infrared fluorescence imaging of lipid-rich, inflamed atherosclerotic plaques.

Biomedical applications of tetrazine cycloadditions.

Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy.

Two-dimensional intravascular near-infrared fluorescence molecular imaging of inflammation in atherosclerosis and stent-induced vascular injury.

Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.

In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).

Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog.

Multiplexed magnetic labeling amplification using oligonucleotide hybridization.

In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation.

Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry.

Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma.

A systems approach for tumor pharmacokinetics.

Bioorthogonal probes for polo-like kinase 1 imaging and quantification.

Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.

Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles.

Nanoparticle-mediated measurement of target-drug binding in cancer cells.

Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles.

Magnetic nanoparticles for biomedical NMR-based diagnostics.

Therapeutic siRNA silencing in inflammatory monocytes in mice.

Different capacity of monocyte subsets to phagocytose iron-oxide nanoparticles.

89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging.

Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance.

Interview: Nanomedicine in oncology: miniaturized means to an enormous end. Interviewed by Cara Sutton.

Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase.

Supramolecular Host-Guest Interaction for Labeling and Detection of Cellular Biomarkers.

Intravital imaging.

Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions.

Bioorthogonal reaction pairs enable simultaneous, selective, multi-target imaging.

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis.

PET/MRI of inflammation in myocardial infarction.

Innate response activator B cells protect against microbial sepsis.

Magnetic Nanoparticles and microNMR for Diagnostic Applications.

Origins of tumor-associated macrophages and neutrophils.

The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.

Development of Secreted Protein and Acidic and Rich in Cysteine (SPARC) Targeted Nanoparticles for the Prognostic Molecular Imaging of Metastatic Prostate Cancer.

Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy.

Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging.

Single reporter for targeted multimodal in vivo imaging.

Reactive polymer enables efficient in vivo bioorthogonal chemistry.

Orthogonal amplification of nanoparticles for improved diagnostic sensing.

Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target.

Synthesis of [18F]BODIPY: bifunctional reporter for hybrid optical/positron emission tomography imaging.

Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents.

Establishment and characterization of a novel chordoma cell line: CH22.

In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution.

Mapping molecular agents distributions in whole mice hearts using born-normalized optical projection tomography.

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Regulation of monocyte functional heterogeneity by miR-146a and Relb.

Bioorthogonal imaging of aurora kinase A in live cells.

Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.

Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders.

A magnetic Gram stain for bacterial detection.

Sensitive and direct detection of circulating tumor cells by multimarker µ-nuclear magnetic resonance.

Mechanism of magnetic relaxation switching sensing.

Myocardial infarction accelerates atherosclerosis.

Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector.

CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy.

Noise suppressed, multifocus image fusion for enhanced intraoperative navigation.

Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators.

Real-time in vivo imaging of the beating mouse heart at microscopic resolution.

Inflammation modulates murine venous thrombosis resolution in vivo: assessment by multimodal fluorescence molecular imaging.

Dual imaging and photoactivated nanoprobe for controlled cell tracking.

Modeling biological activities of nanoparticles.

Improved intravital microscopy via synchronization of respiration and holder stabilization.

Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cells.

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.

Implantable microenvironments to attract hematopoietic stem/cancer cells.

Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway.

Microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Painting blood vessels and atherosclerotic plaques with an adhesive drug depot.

Polymeric nanoparticle PET/MR imaging allows macrophage detection in atherosclerotic plaques.

Angiotensin II Drives the Production of Tumor-Promoting Macrophages.

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.

Nano-SAR development for bioactivity of nanoparticles with considerations of decision boundaries.

μHall Chip for Sensitive Detection of Bacteria.

Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and a miniaturized micro-NMR system.

Fluorescence endoscopy of cathepsin activity discriminates dysplasia from colitis.

Single cell analysis of drug distribution by intravital imaging.

Upconverting organic dye doped core-shell nano-composites for dual-modality NIR imaging and photo-thermal therapy.

Magnetic barcode assay for genetic detection of pathogens.

Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice.

A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria.

A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry.

BODIPY-tetrazine derivatives as superbright bioorthogonal turn-on probes.

Nanoparticle PET-CT detects rejection and immunomodulation in cardiac allografts.

Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection.

Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.

Local proliferation dominates lesional macrophage accumulation in atherosclerosis.

Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells.

Efficient (18)F-Labeling of Synthetic Exendin-4 Analogues for Imaging Beta Cells.