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Sakine Simsekyilmaz

Institute for Molecular Cardiovascular Research

RWTH Aachen University

BIOGRAPHY

Prior to her PhD, Dr. Sakine Simsekyilmaz gained initial experiences in the field of glioblastoma research. During her PhD and as a postdoctoral fellow, she strenghthened her background and knowledge in translational research to investigate potential new therapeutics in the treatment of cardiovascular and metabolic diseases whilst targeting specific cell types.

PUBLICATIONS

C5a receptor targeting in neointima formation after arterial injury in atherosclerosis-prone mice.

Circulation Sep, 2010 | Pubmed ID: 20733098

Neutrophil-derived cathelicidin protects from neointimal hyperplasia.

Science translational medicine Oct, 2011 | Pubmed ID: 21974936

Differential roles of angiogenic chemokines in endothelial progenitor cell-induced angiogenesis.

Basic research in cardiology Jan, 2013 | Pubmed ID: 23184390

CXC chemokine KC fails to induce neutrophil infiltration and neoangiogenesis in a mouse model of myocardial infarction.

Journal of molecular and cellular cardiology Apr, 2013 | Pubmed ID: 23598282

Compartmentalized protective and detrimental effects of endogenous macrophage migration-inhibitory factor mediated by CXCR2 in a mouse model of myocardial ischemia/reperfusion.

Arteriosclerosis, thrombosis, and vascular biology Sep, 2013 | Pubmed ID: 23868943

Role of extracellular RNA in atherosclerotic plaque formation in mice.

Circulation Feb, 2014 | Pubmed ID: 24201302

Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.

PloS one , 2014 | Pubmed ID: 24498325

Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction.

Journal of cellular and molecular medicine May, 2014 | Pubmed ID: 24512349

Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasia after vascular injury in atherosclerosis-prone mice.

Arteriosclerosis, thrombosis, and vascular biology Jun, 2014 | Pubmed ID: 24723559

Response to letter regarding article "Role of extracellular RNA in atherosclerotic plaque formation in mice".

Circulation Oct, 2014 | Pubmed ID: 25311624

Progress in interventional cardiology: challenges for the future.

Thrombosis and haemostasis Mar, 2015 | Pubmed ID: 25608683

Apolipoprotein E deficient rats generated via zinc-finger nucleases exhibit pronounced in-stent restenosis.

Scientific reports 12, 2019 | Pubmed ID: 31796798

INSTITUTIONS

RWTH Aachen University

RWTH Aachen University, Germany

University Hospital RWTH Aachen

JOVE ARTICLES

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Sakine Simsekyilmaz¹,

Fabian Schreiber²,

Stefan Weinandy³,

Felix Gremse⁴,

Tolga Taha Sönmez⁵,

Elisa A. Liehn¹

¹Institute for Molecular Cardiovascular Research, RWTH Aachen University,

²Institute for Textile Technology and Mechanical Engineering, RWTH Aachen University,

³Institute for Applied Medical Engineering, Helmholtz-Institute of RWTH Aachen University,

⁴Department of Experimental Molecular Imaging, RWTH Aachen University,

⁵Department of Oral and Maxillofacila Surgery, RWTH Aachen University

Medicine

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Adelina Curaj¹,

Sakine Simsekyilmaz¹,

Mareike Staudt¹,

Elisa Liehn¹

¹Institute for Molecular Cardiovascular Research, RWTH Aachen University, Germany

Medicine

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Anne Cornelissen^*,1,

Roberta Florescu^*,1,

Nicole Schaaps¹,

Mamdouh Afify¹,

Sakine Simsekyilmaz¹,

Elisa Liehn^*,1,2,3,

Felix Vogt^*,1

¹Division of Cardiology, Angiology, and Critical Care, University Hospital RWTH Aachen,

²Department for Operative Intensive Medicine, University Hospital RWTH Aachen,

³, Institute for Pathology "Victor Babes"

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Sakine Simsekyilmaz

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RWTH Aachen University

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice

Implantation of Human-Sized Coronary Stents into Rat Abdominal Aorta Using a Trans-Femoral Access

Institute for Molecular Cardiovascular Research