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Campbell Family Mental Health Research Institute

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABA_A Receptor Presentation in the Rodent Brain

Akiko Sumitomo¹, Runhao Zhou^1,2, Thomas Prevot^1,3, Etienne Sibille^1,2,3, Toshifumi Tomoda^1,3

¹Centre for Addiction and Mental Health (CAMH), Campbell Family Mental Health Research Institute, ²Department of Pharmacology and Toxicology, University of Toronto, ³Department of Psychiatry, University of Toronto

The BS3 chemical crosslinking assay reveals reduced cell surface GABA_A receptor expression in mouse brains under chronic psychosocial stress conditions.