Development and Evaluation of a Rat Model of Full-Thickness Cartilage DefectsHaiyan Zhang *1, Ronghua Bao *2, Jiaan Xu 3, Yanzhi Ge 4, Zuxiang Chen 1, Mengqiang Fan 1, Guangping Yu 5, Li Zhou 1, Le Guo 3, Letian Shan 1, Hangxing Bao 1
1The First Affiliated Hospital, Zhejiang Chinese Medical University, 2Fuyang Orthopaedics and Traumatology Affiliated Hospital, Zhejiang Chinese Medical University, 3College of Pharmaceutical Science, Zhejiang Chinese Medical University, 4Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, 5Xianju County Hospital of Chinese Medicine
This protocol establishes a full-thickness cartilage defects (FTCD) model by drilling holes in the femoral trochlear groove of rats and measuring the subsequent pain behavior and histopathological changes.
