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German Center for Neurodegenerative Diseases (DZNE) eV.

1 ARTICLES PUBLISHED IN JoVE

Biology

Cost-Efficient Transcriptomic-Based Drug Screening

Jacqueline Leidner^1,2, Heidi Theis³, Michael Kraut³, Alice Ragogna¹, Marc Beyer^1,3,4, Joachim Schultze^1,2,3, Jonas Schulte-Schrepping^1,2, Caterina Carraro^1,2, Lorenzo Bonaguro^1,2

¹Systems Medicine, German Center for Neurodegenerative Diseases (DZNE) eV., ²Genomics & Immunoregulation, LIMES Institute, University of Bonn, ³PRECISE Platform for Single Cell Genomics and Epigenomics, DZNE and University of Bonn, ⁴Immunogenomics & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE) eV.

This protocol describes a workflow from ex vivo or in vitro cell cultures to transcriptomic data pre-processing for cost-effective transcriptome-based drug screening.