NATIONAL INSTITUTE ON AGING
2 ARTICLES PUBLISHED IN JoVE
Medicine
A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
Natalia Petrasheskaya 1, Hyun-Jin Tae 1,2, Ismayil Ahmet 1, Mark I. Talan 1, Edward G. Lakatta 1, Li Lin 1
1Laboratory of Cardiovascular Sciences, National Institute on Aging, 2Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University
The rat carotid balloon injury model described below allows researchers to evaluate drugs or therapeutics that negate injury-induced arterial hyperplasia. Detailed pre-surgical preparation, surgical procedure, and post-surgical cares of the animal are described.
Medicine
Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Vidhya Kumar 1, Henry Chang 1, David A. Reiter 2, David P. Bradley 3, Martha Belury 4, Shana E. McCormack 5, Subha V. Raman 1
1Davis Heart and Lung Research Institute, The Ohio State University, 2Laboratory of Clinical Investigation, National Institute on Aging, 3Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, 4Department of Human Sciences, Human Nutrition, The Ohio State University, 5Division of Endocrinology and Diabetes, Department of Pediatrics, University of Pennsylvania
This work demonstrates the feasibility of an in vivo phosphorus-31 magnetic resonance spectroscopy (31PMRS) technique to quantify mitochondrial oxidative phosphorylation (OXPHOS) capacity in human skeletal muscle.
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