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Texas A&M University-Commerce

2 ARTICLES PUBLISHED IN JoVE

JoVE Journal

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Enas N. Yousef¹, Ramakrishna Sesham¹, Jacob W. McCabe¹, Rajpal Vangala¹, Laurence A. Angel¹

¹Department of Chemistry, Texas A&M University-Commerce

Ion mobility-mass spectrometry and molecular modeling techniques can characterize the selective metal chelating performance of designed metal-binding peptides and the copper-binding peptide methanobactin. Developing new classes of metal chelating peptides will help lead to therapeutics for diseases associated with metal ion misbalance.

Chemistry

Thermochemical Studies of Ni(II) and Zn(II) Ternary Complexes Using Ion Mobility-Mass Spectrometry

Anna J. Corrales¹, Anna V. Arredondo¹, Amber A. Flores¹, Chloe L. Duvak¹, Charles L. Mitchell¹, Riccardo Spezia², Laurence A. Angel¹

¹Department of Chemistry, Texas A&M University-Commerce, ²Laboratoire de Chimie Théorique, Sorbonne Université

This article describes an experimental protocol using electrospray-ion mobility-mass spectrometry, semi-empirical quantum calculations, and energy-resolved threshold collision-induced dissociation to measure the relative thermochemistry of the dissociation of related ternary metal complexes.