Modeling and Imaging 3-Dimensional Collective Cell InvasionRebecca W. Scott 1, Diane Crighton 2, Michael F. Olson 2
1Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde , 2The Beatson Institute for Cancer Research
Models of tumor cell invasion into three-dimensional extracellular matrix better reflect the in vivo situation than two-dimensional motility assays. Using matrix invasion assays combined with confocal imaging of fluorescently-labeled cells, detailed information on invasion modes and the distinct contributions of leading versus following cells can be obtained.
