Medtronic Inc.
2 ARTICLES PUBLISHED IN JoVE
Medicine
Direct Pressure Monitoring Accurately Predicts Pulmonary Vein Occlusion During Cryoballoon Ablation
Ioanna Kosmidou 1, Shannnon Wooden 1, Brian Jones 2, Thomas Deering 1, Andrew Wickliffe 1, Dan Dan 1
1Department of Cardiac Electrophysiology, Piedmont Heart Institute, 2Cardiac Rhythm, Medtronic Inc.
Effective pulmonary vein isolation utilizing a cryoballoon depends on complete pulmonary vein occlusion. The point of occlusion can be effectively predicted by direct analysis of pulmonary vein pressure waveform analysis during balloon inflation using a simple and reproducible technique.
Immunology and Infection
A Cryo-pulverization Protocol for Processing Mouse Paws to Evaluate Molecular Pathways of Tissue Inflammation in a Collagen Induced Arthritis Model
Brian Jones 1, Shannon Hitchcock 1, Matthew Loza 1, Ravi Malaviya 1, Tatiana Ort 1, Fang Shen 1
1Immunology, Janssen Research & Development, Inc.
A cryogenic pulverization method to process murine paws using a liquid nitrogen freezer mill was developed to improve the yield and quality of RNA or protein extracted from the tissues and enable the analysis of molecular profiles associated with inflammatory responses.
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