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National Institutes for Quantum and Radiological Science and Technology

1 ARTICLES PUBLISHED IN JoVE

Bioengineering

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Yoichi Takakusagi¹

¹Institute of Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology

This study aimed to present a strategy for identifying drug-peptide interactions. The strategy involves the biopanning of drug-recognizing short peptides based on a quartz-crystal microbalance (QCM) biosensor, followed by bioinformatics analysis for quantitatively assessing the information obtained for the drug recognition and annotation of the drug-binding sites on proteins.