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Rouen University Hospital

3 ARTICLES PUBLISHED IN JoVE

Neuroscience

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury

Nicolas Guerout^1,2, Alexandre Paviot^1,3, Nicolas Bon-Mardion^1,3, Axel Honoré¹, Rais OBongo^1,4, Célia Duclos¹, Jean-Paul Marie^1,3

¹UPRES EA3830, Institute for Research and Innovation in Biomedicine, University of Rouen, ²Neuroscience, Karolinska Institutet, ³Otorhinolaryngology, Head and Neck Surgery Department, Rouen University Hospital, ⁴Otorhinolaryngology, Head and Neck Surgery Department, Amiens University Hospital

Olfactory ensheathing cells (OECs) are neural crest cells which allow growth of the primary olfactory neurons. This specific property can be used for cellular transplantation. We present here a model of cellular transplantation based on the use of OECs in a laryngeal nerve injury model.

JoVE Core

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Thomas Clavier^1,2, Sébastien Franchina¹, Antoine Lefevre-Scelles¹, Philippe Gouin¹, Emmanuel Besnier^1,2, Benoit Veber¹

¹Department of Anesthesiology and Critical Care, Rouen University Hospital, ²Normandie Univ, UNIROUEN, INSERM U1096

We present a protocol to show the installation of a needle-free connector with positive displacement on a central venous catheter.

Neuroscience

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Martin Pedard¹, Mohamad El Amki¹, Antoine Lefevre-Scelles^1,2, Vincent Compère^1,2, Hélène Castel¹

¹University of Rouen Normandy, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France, ²Department of Anesthesiology and Critical Care, Rouen University Hospital, Rouen, France

We described in this protocol a standardized subarachnoid hemorrhage (SAH) mouse model by a double injection of autologous whole-blood into the cisterna magna. The high degree of standardization of the double-injection procedure represents a middle-to-acute model of SAH with relative safety regarding mortality.