Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood FlowAntonia Link 1, Giorgio Cattaneo 2,3, Eduard Brynda 4, Tomas Riedel 4, Johanka Kucerova 4, Christian Schlensak 1, Hans Peter Wendel 1, Stefanie Krajewski 1, Tatjana Michel 1
1Department of Thoracic, Cardiac and Vascular Surgery, University Hospital Tuebingen, 2Acandis GmbH, 3Institute of Biomedical Engineering, University of Stuttgart, 4Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic
This protocol describes a comprehensive hemocompatibility evaluation of blood-contacting devices using laser-cut neurovascular implants. A flow loop model with fresh, heparinized human blood is applied to mimic blood flow. After perfusion, various hematologic markers are analyzed and compared to the values gained directly after blood collection for hemocompatibility evaluation of the tested devices.
