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Howards Hughes Medical Institute

1 ARTICLES PUBLISHED IN JoVE

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Neuroscience

Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
Marie Vandecasteele 1,2, S. M. 1, Sébastien Royer 1,3, Mariano Belluscio 1, Antal Berényi 1, Kamran Diba 1,4, Shigeyoshi Fujisawa 1, Andres Grosmark 1, Dun Mao 1, Kenji Mizuseki 1, Jagdish Patel 1, Eran Stark 1, David Sullivan 1, Brendon Watson 1, György Buzsáki 1
1Center for Molecular and Behavioral Neuroscience, University of New Jersey, 2Center for Interdisciplinary Research in Biology, Collège de France, 3Janelia Farm Research Campus, Howards Hughes Medical Institute, 4Deptartment of Psychology, University of Wisconsin at Milwaukee

We describe methods for large-scale recording of multiple single units and local field potential in behaving rodents with silicon probes. Drive fabrication, probe attachment to the drive and probe implantation processes are illustrated in sufficient details for easy replication.

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