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Japan Tobacco Inc.

1 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle

Hironori Nishitsuji¹, Hiromi Yamamoto¹, Ritsuko Shiina¹, Keisuke Harada², Saneyuki Ujino¹, Kunitada Shimotohno¹

¹Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine, ²Central Pharmaceutical Research Institute, Japan Tobacco Inc.

Here we describe a newly developed hepatitis B virus (HBV) reporter system to monitor the early stages of the HBV life cycle. This simplified in vitro system will aid in the screening of anti-HBV agents using a high-throughput strategy.