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Tabriz University of Medical Sciences

3 ARTICLES PUBLISHED IN JoVE

Biology

Cellular Toxicity of Nanogenomedicine in MCF-7 Cell Line: MTT assay

Somaieh Ahmadian^1,2, Jaleh Barar^1,3, Amir Ata Saei¹, Mohammad Amin Abolghassemi Fakhree², Yadollah Omidi^1,3

¹Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University (Medical Sciences), ²Gifted and Talented Students Office, Educational Development Center, Tabriz University (Medical Sciences), ³School of Advanced Biomedical Sciences, Tabriz University (Medical Sciences)

The MTT assay is an easy and reproducible colorimetric assay for evaluation of cell viability based on reduction of yellow MTT and production of water insoluble purple formazan. Here, the viability of MCF-7 cells upon treatment of nanogenomedicine has been evaluated.

Neuroscience

An In Vivo Assessment of Blood-Brain Barrier Disruption in a Rat Model of Ischemic Stroke

Hamdollah Panahpour¹, Mehdi Farhoudi², Yadollah Omidi³, Javad Mahmoudi²

¹Department of Physiology, Medical School, Ardabil University of Medical Sciences, ²Neurosciences Research Center, Tabriz University of Medical Sciences, ³Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences

The overall goal of this procedure is to provide a highly reproducible technique for in vivo assessment of the blood-brain barrier disruption in rat models of ischemic stroke.

Neuroscience

A Protocol for Transcranial Photobiomodulation Therapy in Mice

Farzad Salehpour^1,2, Luis De Taboada³, Paolo Cassano^4,5,6, Farzin Kamari¹, Javad Mahmoudi¹, Sohrab Ahmadi-Kandjani⁷, Seyed Hossein Rasta^8,9,10, Saeed Sadigh-Eteghad¹

¹Neurosciences Research Center, Tabriz University of Medical Sciences, ²ProNeuroLIGHT LLC, ³LiteCure LLC, ⁴Department of Psychiatry, Harvard Medical School, ⁵Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, ⁶Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, ⁷Research Institute for Applied Physics and Astronomy, University of Tabriz, ⁸Department of Medical Physics, Tabriz University of Medical Sciences, ⁹Department of Medical Bioengineering, Tabriz University of Medical Sciences, ¹⁰School of Medical Sciences, University of Aberdeen

Photobiomodulation therapy is an innovative noninvasive modality for the treatment of a wide range of neurological and psychiatric disorders and can also improve healthy brain function. This protocol includes a step-by-step guide to performing brain photobiomodulation in mice by transcranial light delivery, which can be adapted for use in other laboratory rodents.