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Guangdong General Hospital (Guangdong Academy of Medical Sciences)

3 ARTICLES PUBLISHED IN JoVE

Medicine

Construction and Evaluation of a Murine Calvarial Osteolysis Model by Exposure to CoCrMo Particles in Aseptic Loosening

Hui Jiang^*1, Yicun Wang^*1, Zhantao Deng^*1,2,3, Jiewen Jin^2,3, Jia Meng¹, Shuo Chen¹, Jun Wang¹, Yang Qiu¹, Ting Guo¹, Jianning Zhao¹

¹Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University, ²Center for Translational Medicine, Nanjing University Medical School, ³Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School

This manuscript describes a murine calvarial osteolysis model by exposure to CoCrMo particles, which constitutes an ideal animal model for assessing the interactions between wear particles and various cells in aseptic loosening.

Medicine

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis

Ziming Chen^*1,2, Zhantao Deng^*1, Yuanchen Ma¹, Junxing Liao¹, Qingtian Li¹, Mengyuan Li¹, Hua Liu¹, Ganghong Chen¹, Chaoming Zeng¹, Qiujian Zheng¹

¹Department of Orthopedics, Guangdong General Hospital (Guangdong Academy of Medical Sciences), ²Shantou University Medical College

Knee osteoarthritis is frequently seen in the orthopedic department. We introduce in detail the entire knee osteoarthritis treatment process with platelet-rich plasma injection, including preparation, procedures, and evaluation.

Medicine

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Ziming Chen^*1, Peilin Chen^*1, Rui Ruan^*1, Lianzhi Chen¹, Jun Yuan¹, David Wood¹, Tao Wang¹, Ming Hao Zheng¹

¹Centre of Orthopaedic Translational Research, Medical School, University of Western Australia

A three-dimensional uniaxial mechanical stimulation bioreactor system is an ideal bioreactor for tenogenic-specific differentiation of tendon-derived stem cells and neo-tendon formation.