Cell-based Assay to Study Antibody-mediated Tau Clearance by MicrogliaDonata De Marco 1, Renske Taggenbrock 2,3, Rosa Crespo 3, Wouter Koudstaal 3, Elizabeth Ramsburg 4, Adrian Apetri 3
1Neuroscience Discovery, Janssen Pharmaceutical Company of Johnson & Johnson, Belgium, 2Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, The Netherlands, 3Janssen Prevention Center, Janssen Pharmaceutical Company of Johnson & Johnson, The Netherlands, 4Neuroscience Discovery, Janssen Pharmaceutical Company of Johnson & Johnson, Pennsylvania
Here we describe a cell-based assay to quantitatively assess tau uptake by microglia with the aim of creating an investigational tool to better characterize the mechanisms of action of anti-tau antibodies.
