Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous SystemYi Chen *1, Curt Mazur *2, Yi Luo *1, Linhong Sun 1, Mingdi Zhang 1, Alex McCampbell 1, Giulio Srubek Tomassy 1
1Biogen, Inc., 2Ionis Pharmaceuticals
Here, we describe a method for delivering drugs to the rat central nervous system by implanting a catheter into the lumbar intrathecal space of the spine. We focus on the delivery of antisense oligonucleotides, though this method is suitable for delivery of other therapeutic modalities as well.
